Functionalization of epoxy esters with alcohols as stoichiometric reagents

Abstract

Dedicated to the memory of Prof. Dr. Jurij V. Bren~i~. AbstractGlycidyl esters, frequently employed as reactive groups on polymeric supports, were functionalized with alcohols as stoichiometric reagents, yielding β-alkoxyalcohols. Among the solvents studied, best results were obtained in ethers in the presence of a strong proton acid as a catalyst. Alcohols include simple alkanols, diols, protected polyols, 3-butyn-1-ol, 3-hydroxypropanenitrile and cholesterol. This protocol represents a convenient way for introduction of various functionalities onto epoxy-functionalized polymers. Under the reaction conditions, some side reactions take place, mostly due to the reactive ester group and water present in the reaction mixture.

Synthesis, Antimicrobial Activity and in silico Studies on Thymol Esters

“…The conversion of the other carboxylic acids to acyl chlorides 37,38 and the preparation of thymyl esters utilized methods from the literature. 39,40 Scheme 1 presents the synthesis of thymyl esters.…”

Synthesis, Antimicrobial Activity and in silico Studies on Eugenol Eters

“…Acetyl, benzoyl and palmitoyl chloride (2a, 2r, 2s) were purchased from Sigma-Aldrich. For the preparation of acyl chlorides 2b-p, 2r and of eugenyl esters (Table 1, entries 3a-s) methods from the literature [39][40][41][42] were utilized and general procedures for the synthesis as reported in our previously published paper was followed. 43 Scheme 1 represents the synthesis of eugenyl esters.…”