Functionalization of Crosslinked Sodium Alginate/Gelatin Wet-Spun Porous Fibers with Nisin Z for the Inhibition of Staphylococcus aureus-Induced Infections

Homem, Natália C.; Tavares, Tânia D.; Miranda, Catarina S.; Antunes, Joana C.; Amorim, M. T. Pessoa de; Felgueiras, Helena P.

doi:10.3390/ijms22041930

Cited by 21 publications

(11 citation statements)

References 56 publications

(87 reference statements)

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“…Tuning their properties via adjusting processing, solution, or environmental parameters, using a combination of natural and synthetic polymers with biodegradable characteristics, is considered the most reliable option. Complex architectures and configurations such as those highlighted in this review can generate systems that respond more intimately to local demands, while guaranteeing the safety of the user [13,118,122,163,168]. Indeed, by introducing drug delivery systems in which drugs are protected by an additional layer can prevent initial burst release and toxic side effects to the human body.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the cylindrical shape of the fibers increases the surface area to volume ratio of the system, which allows drug release over broader area. Besides, the length and cross-sectional radius can be tuned according to the solution and processing parameters applied, contrary to spherical vesicles which tend to be more limited [162,163]. There are still not many reports on the production of more complex fiber architects for biomedical applications, due to the complexity of the structures and the number of parameters that have to be optimized.…”

Section: Tissue Engineering and Drug Delivery Applicationsmentioning

confidence: 99%

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Tunable Spun Fiber Constructs in Biomedicine: Influence of Processing Parameters in the Fibers’ Architecture

et al. 2022

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Electrospinning and wet-spinning have been recognized as two of the most efficient and promising techniques for producing polymeric fibrous constructs for a wide range of applications, including optics, electronics, food industry and biomedical applications. They have gained considerable attention in the past few decades because of their unique features and tunable architectures that can mimic desirable biological features, responding more effectively to local demands. In this review, various fiber architectures and configurations, varying from monolayer and core-shell fibers to tri-axial, porous, multilayer, side-by-side and helical fibers, are discussed, highlighting the influence of processing parameters in the final constructs. Additionally, the envisaged biomedical purposes for the examined fiber architectures, mainly focused on drug delivery and tissue engineering applications, are explored at great length.

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Section: Discussionmentioning

confidence: 99%

Section: Tissue Engineering and Drug Delivery Applicationsmentioning

confidence: 99%

Tunable Spun Fiber Constructs in Biomedicine: Influence of Processing Parameters in the Fibers’ Architecture

et al. 2022

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“…Sodium alginate (SA) is a linear polysaccharide derived from brown seaweed [ 55 ]. More specifically, SA is a derivative of alginic acid and is composed of α-1-guluornic (G) and 1,4-linked-β-D-mannuronic (M) monomers [ 55 ].…”

Section: Natural Biopolymer Scaffolds For Therapeutic Ev Deliverymentioning

confidence: 99%

Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges

Leung

Shirazi

Cooper

et al. 2022

Cells

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In this review, we will discuss the current status of extracellular vesicle (EV) delivery via biopolymeric scaffolds for therapeutic applications and the challenges associated with the development of these functionalized scaffolds. EVs are cell-derived membranous structures and are involved in many physiological processes. Naïve and engineered EVs have much therapeutic potential, but proper delivery systems are required to prevent non-specific and off-target effects. Targeted and site-specific delivery using polymeric scaffolds can address these limitations. EV delivery with scaffolds has shown improvements in tissue remodeling, wound healing, bone healing, immunomodulation, and vascular performance. Thus, EV delivery via biopolymeric scaffolds is becoming an increasingly popular approach to tissue engineering. Although there are many types of natural and synthetic biopolymers, the overarching goal for many tissue engineers is to utilize biopolymers to restore defects and function as well as support host regeneration. Functionalizing biopolymers by incorporating EVs works toward this goal. Throughout this review, we will characterize extracellular vesicles, examine various biopolymers as a vehicle for EV delivery for therapeutic purposes, potential mechanisms by which EVs exert their effects, EV delivery for tissue repair and immunomodulation, and the challenges associated with the use of EVs in scaffolds.

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“…In all cases, AMPs act against the microbial cells by disrupting the membrane/wall/envelope integrity, inhibiting proteins', nucleic acids', or other important compounds' synthesis, or by permeabilizing the microorganism and interacting with certain intracellular targets (Figure 2). One of the most important features of AMPs is their ability to act against microbial cells using a multi-hit strategy based on non-specific mechanisms of action, which tends to broaden their spectrum of antimicrobial action even against multi-resistant pathogens [8,17,28,29]. Recent studies have reported evidence of resistance mechanisms by pathogens against naturally occurring skin AMPs.…”

Section: Antimicrobial Peptidesmentioning

confidence: 99%

An Insight into Biomolecules for the Treatment of Skin Infectious Diseases

Felgueiras

2021

Pharmaceutics

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In assigning priorities, skin infectious diseases are frequently classified as minor when compared to infectious diseases of high mortality rates, such as tuberculosis or HIV. However, skin infections are amongst the most common and prevalent diseases worldwide. Elderly individuals present an increased susceptibility to skin infections, which may develop atypical signs and symptoms or even complicate pre-existing chronic disorders. When the skin fails to correct or inhibit the action of certain pathogenic microorganisms, biomolecules endowed with antimicrobial features are frequently administered topically or systemically to assist or treat such conditions. (1) Antibiotics, (2) antimicrobial peptides, or (3) natural extracts display important features that can actively inhibit the propagation of these pathogens and prevent the evolution of infectious diseases. This review highlights the properties and mechanisms of action of these biomolecules, emphasizing their effects on the most prevalent and difficult to treat skin infections caused by pathogenic bacteria, fungi, and viruses. The versatility of biomolecules’ actions, their symbiotic effects with skin cells and other inherent antimicrobial components, and their target-directed signatures are also explored here.

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Functionalization of Crosslinked Sodium Alginate/Gelatin Wet-Spun Porous Fibers with Nisin Z for the Inhibition of Staphylococcus aureus-Induced Infections

Abstract: [...]

Cited by 21 publications

References 56 publications

Tunable Spun Fiber Constructs in Biomedicine: Influence of Processing Parameters in the Fibers’ Architecture

Tunable Spun Fiber Constructs in Biomedicine: Influence of Processing Parameters in the Fibers’ Architecture

Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges

An Insight into Biomolecules for the Treatment of Skin Infectious Diseases

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