Functionalization of Biomolecules With Nanostructured Porous Silicon for Biomedical Application

Abstract

Porous silicon (PS) fabrication, changes in the optical properties and surface modi¯cation in the oxidized PS (dipped into the Glucose oxide) due to the in¯ltration of biomolecules using Luminescence Spectrophotometer [Photoluminescence (PL)], Fourier Transform Infrared Spectroscopy (FTIR), and Scanning Electron Microscope (SEM) were studied. The surface morphology of oxidized PS (OPS) and treated with Glucose have been studied by SEM. Spontaneous imbibition weight was calculated theoretically using imbibition equation for the porous medium using glucose solution as the wetting liquid. FTIR analysis revealed that, the strong Si-H, Si-O-Si bonds which covered most of the OPS surface. In the glucose treated PS layer, the amide I (C¼O) stretch and amide II (C¼N) stretch (1690 cm À1 and 1551 cm À1 Þ groups were appeared in the spectrum which con¯rmed the coupling reaction. E±cient visible Photoluminescence was obtained at around 624 nm from glucose treated porous silicon. The functionalization of glucose with nano structured PS, changes light emission over the surface of OPS. It can be applied in optical biosensor and which can be used in biomedical applications.

Porous Nanomaterials Targeting Autophagy in Bone Regeneration

“…PNMs are nanomaterials with a porous structure and high surface ratio, which are widely used in the fields of biomedical engineering [14][15][16][17][18] such as bone regeneration [18][19][20][21], drug delivery [22][23][24], cell trace, and regulation of cell differentiation. Since 2014, it has been reported that mesoporous bioactive glass nanomaterials can promote osteogenic differentiation through activation of autophagy [25].…”