Functionalization of Alkynes for Preparing Alkenyl Fluorides

Preparation of [18F]Alkenyl Fluorides Using No-Carrier-Added [18F]AgF via Silver-Mediated Direct Radiofluorination of Alkynes

“…Common 18 F radiosynthesis precursors include carbon electrophiles (R–X, where X = halides or pseudo halides) and organometals (R–M, where M = B, Sn, or Si) (Scheme a) . Alkynes are ubiquitous in organic synthesis, and unlike common 18 F radiosynthesis precursors such as RX and RM, alkynes are generally chemically inert under most reaction conditions (acids, bases, oxidants, and reductants) . Therefore, alkynes are ideal 18 F radiosynthesis precursors, especially for late-stage radiofluorinations.…”