Functionalization, cyclization and antiviral activity of A-secotriterpenoids

Гришко, В. В.; Galaiko, Natalia V.; Толмачева, И. А.; Kucherov, I. I.; Vf, Eremin; Бореко, Е. И.; Savinova, Olga V.; Слепухин, П. А.

doi:10.1016/j.ejmech.2013.12.058

Cited by 36 publications

(21 citation statements)

References 35 publications

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“…Certain pentacyclic triterpenoids with conserved structural features displayed in vitro antiinfluenza virus activity that is comparable to or higher than that of oseltamivir [10,11]. Based on the above results, we chose compound 3 as the lead compound and designed analogs 4e16 with the aim to investigate the SARs of pentacyclic triterpenes with different aglycones.…”

Section: Introductionmentioning

confidence: 99%

Structure–activity relationships of 3-O-β-chacotriosyl ursolic acid derivatives as novel H5N1 entry inhibitors

Song

Shen

et al. 2015

European Journal of Medicinal Chemistry

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Section: Introductionmentioning

confidence: 99%

Structure–activity relationships of 3-O-β-chacotriosyl ursolic acid derivatives as novel H5N1 entry inhibitors

Song

Shen

et al. 2015

European Journal of Medicinal Chemistry

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“…At present, one of the most common ways to increase the effectiveness and bioavailability of triterpenoids is by chemical modification. This usually requires high temperature and pH, use of expensive reagents, and introduction of protective groups of molecule reactive centers [8][9][10][11]. An alternative way to obtain valuable derivatives is by biotransformation under normal and environmentally friendly conditions employing the catalytic activity of microorganisms with high regio-and stereoselectivity in one…”

Section: Introductionmentioning

confidence: 99%

Biotransformation of Oleanane and Ursane Triterpenic Acids

2020

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Oleanane and ursane pentacyclic triterpenoids are secondary metabolites of plants found in various climatic zones and regions. This group of compounds is highly attractive due to their diverse biological properties and possible use as intermediates in the synthesis of new pharmacologically promising substances. By now, their antiviral, anti-inflammatory, antimicrobial, antitumor, and other activities have been confirmed. In the last decade, methods of microbial synthesis of these compounds and their further biotransformation using microorganisms are gaining much popularity. The present review provides clear evidence that industrial microbiology can be a promising way to obtain valuable pharmacologically active compounds in environmentally friendly conditions without processing huge amounts of plant biomass and using hazardous and expensive chemicals. This review summarizes data on distribution, microbial synthesis, and biological activities of native oleanane and ursane triterpenoids. Much emphasis is put on the processes of microbial transformation of selected oleanane and ursane pentacyclic triterpenoids and on the bioactivity assessment of the obtained derivatives.

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“…Terpenes act on gram-positive bacteria, less than gram-negative bacteria. [1] Monoterpenoids with nitrogen atoms, generally oxymes, or amines have various biological properties, such as anticancer [2], antimicrobial [3], antiviral [4].…”

Section: Introductionmentioning

confidence: 99%