Functionality of Nonfunctional Diluent Ligands within Bicomponent Layers on Nanoparticles

Abstract

The selective binding of nanoparticles to a specific entity is highly important for building assembly based superstructures and detecting various biomarkers and targets. Such type of binding can only be achieved by controlling the particle surface properties. Herein, we demonstrate the construction of a solid/liquid interfacial layer comprising multiple components on nanoparticle surfaces in order to obtain the desired binding properties. In addition to the actual binding components, the chemical structures of nonfunctional diluent ligands play a significant role in determining the overall binding properties of the nanoparticles. We also evaluated the binding properties of the nanoparticles coated with multiple components and optimized them by varying the interfacial coating conditions. Gold nanoparticles and single-stranded oligonucleotides are chosen as the core nanoparticles and coating functional ligands for model system, respectively, and examined in the presence of various chemical and biological diluents.

DNA-Functionalized Gold Nanoparticles with Toehold-Mediated Strand Displacement for Nucleic Acid Sensors

“…The observations on the nanoparticle aggregation behavior reflect the cooperativity effect. ,− When the DNA density is high, there are many DNA linkers at the interparticle junction; they synergistically enhance the apparent affinity of a single duplex. This phenomenon is known as avidity, where one hybridization event can enhance other strands at the interparticle space to hybridize due to the aligned orientation and proximity of DNA that has limited lateral flexibility .…”

One-Pot Synthesis of a Zwitterionic Small Molecule Bearing Disulfide Moiety for Antibiofouling Macro- and Nanoscale Gold Surfaces

“…Although the antibiofouling effect of p -DPDSPS was clearly demonstrated on two-dimensional surfaces, it is still a question if nanoparticles can be protected by p -DPDSPS from protein adsorption. While two-dimensional flat surfaces and curved nanoparticle surfaces have the surface chemistry of gold in common, there are several issues to be addressed, including (1) nanoparticle stability after ligand conjugation, (2) ligand density on the nanoparticle surface, , and (3) the resultant antibiofouling effect against proteins . We first examined how to control the density of p -DPDSPS on AuNP surfaces by adjusting the conditions under which p -DPDSPS and AuNPs were conjugated.…”

Electrochemical oscillation during galvanostatic charging and discharging of Zr-modified Li4Ti5O12 in Li-ion batteries

“…The Zr doping has been adopted to improve the electrochemical properties of Li 4 Ti 5 O 12 , in which the substitution of Zr for Ti leads to the slight increase of lattice parameters. [16][17][18][19][20] Through atomic layer deposition, the ZrO 2 ultrathin lm has been directly deposited on Li 4 Ti 5 O 12 electrode to improve its electrochemical performance. 21 However, there is no report about the electrochemical oscillation of Li 4 Ti 5 O 12 with Zr doping, ZrO 2 coating or mixture.…”