Functionalised biomaterials as synthetic extracellular matrices to promote vascularisation and healing of diabetic wounds

Browne, Shane; Petit, Noémie; Quondamatteo, Fabio

doi:10.1007/s00441-023-03849-4

Cell Tissue Res

2023

DOI: 10.1007/s00441-023-03849-4

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Functionalised biomaterials as synthetic extracellular matrices to promote vascularisation and healing of diabetic wounds

Shane Browne,

Noémie Petit,

Fabio Quondamatteo

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2024

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Extracellular matrix-inspired biomaterials for wound healing

Hosty,

Heatherington,

Quondamatteo

et al. 2024

Mol Biol Rep

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Diabetic foot ulcers (DFU) are a debilitating and life-threatening complication of Diabetes Mellitus. Ulceration develops from a combination of associated diabetic complications, including neuropathy, circulatory dysfunction, and repetitive trauma, and they affect approximately 19–34% of patients as a result. The severity and chronic nature of diabetic foot ulcers stems from the disruption to normal wound healing, as a result of the molecular mechanisms which underly diabetic pathophysiology. The current standard-of-care is clinically insufficient to promote healing for many DFU patients, resulting in a high frequency of recurrence and limb amputations. Biomaterial dressings, and in particular those derived from the extracellular matrix (ECM), have emerged as a promising approach for the treatment of DFU. By providing a template for cell infiltration and skin regeneration, ECM-derived biomaterials offer great hope as a treatment for DFU. A range of approaches exist for the development of ECM-derived biomaterials, including the use of purified ECM components, decellularisation and processing of donor/ animal tissues, or the use of in vitro-deposited ECM. This review discusses the development and assessment of ECM-derived biomaterials for the treatment of chronic wounds, as well as the mechanisms of action through which ECM-derived biomaterials stimulate wound healing.

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Extracellular matrix-inspired biomaterials for wound healing

Hosty,

Heatherington,

Quondamatteo

et al. 2024

Mol Biol Rep

View full text Add to dashboard Cite

show abstract

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Functionalised biomaterials as synthetic extracellular matrices to promote vascularisation and healing of diabetic wounds

Cited by 1 publication

References 123 publications

Extracellular matrix-inspired biomaterials for wound healing

Extracellular matrix-inspired biomaterials for wound healing

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