Functionalisation of TiO2 nanoparticles with a fluorescent organosilane: A synergy enabling their visualisation in biological cells and an enhanced photocatalytic activity

Wintzheimer, Susanne; Genin, Émilie; Vellutini, Luc; Bourdon, Gwénaëlle Le; Kessler, M.; Hackenberg, Stephan; Dembski, Sofia; Heuzé, Karine

doi:10.1016/j.colsurfb.2019.05.060

Cited by 6 publications

(2 citation statements)

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“…Early-stage diagnosis and comprehensive understanding of diseases for employing an efficient therapy can be established through using ultrasensitive bioprobes [189]. A nontoxic surface modification by using a fluorescent molecule [23] with permission from the Springer Nature such as rhodamine B on the surface of anatase TiO 2 nanoparticles can be the easiest option for the bioimaging of the target cells [190]. The sandwich-type electrochemiluminescence based on the tetragonal rutile TiO 2 mesocrystals has also been developed to detect zearalenone, which is a mycotoxin secreted by Fusarium (human food contaminants).…”

Section: Bioimagingmentioning

confidence: 99%

Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Kafshgari

Goldmann

2020

Nano-Micro Lett.

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HIGHLIGHTS • Multifunctional TiO 2 nanostructures hold promise for advancing a wide range of biomedical applications due to a feasible integration of distinct theranostic features. • Fabrication and post-fabrication strategies implemented to generate multifunctional TiO 2 nanostructures for a broad range of biomedical applications are briefly outlined. The opportunities and challenges of TiO 2 nanomaterials are highlighted in order to open the possibility of clinical translation. ABSTRACT Titanium dioxide (TiO 2 ) nanostructures exhibit a broad range of theranostic properties that make them attractive for biomedical applications. TiO 2 nanostructures promise to improve current theranostic strategies by leveraging the enhanced quantum confinement, thermal conversion, specific surface area, and surface activity. This review highlights certain important aspects of fabrication strategies, which are employed to generate multifunctional TiO 2 nanostructures, while outlining post-fabrication techniques with anemphasis on their suitability for nanomedicine. The biodistribution, toxicity, biocompatibility, cellular adhesion, and endocytosis of these nanostructures, when exposed to biological microenvironments, are examined in regard to their geometry, size, and surface chemistry. The final section focuses on recent biomedical applications of TiO 2 nanostructures, specifically evaluating therapeutic delivery, photodynamic and sonodynamic therapy, bioimaging, biosensing, tissue regeneration, as well as chronic wound healing.

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Section: Bioimagingmentioning

confidence: 99%

Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Kafshgari

Goldmann

2020

Nano-Micro Lett.

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“…Functionalization agent induced oriented attachment as the origin of the elongation of the TiO 2 NPs has been reported in Dalod et al 13 Hydrophilic TiO 2 NPs could be converted into hydrophobic ones by silylation of their surface hydroxyl groups 14 . Synthesis of identical, highly crystalline anatase NPs differing only in size and surface composition, with control over the density of the functional surface groups, has been attained as reported in Kotsokechagia et al 15 Controlled functionalization of TiO 2 NPs with an organic chromophore was demonstrated as an efficient procedure to enable the visualization of the NPs within cells 16 …”

Section: Introductionmentioning

confidence: 97%

Organic surface modification and analysis of titania nanoparticles for self‐assembly in multiple layers

Hodoroabă

Rades

Borghetti

et al. 2020

Surface & Interface Analysis

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The characteristics of TiO2 coatings can greatly influence their final performance in large‐scale applications. In the present study, self‐assembly of TiO2 nanoparticles (NPs) in multiple layers was selected as a deposition procedure on various substrates. For this, the main prerequisite constitutes the surface modification of both NPs and substrate with, for example, silane coupling agents. A set of functionalized TiO2 NPs has been produced by reaction with either (3‐aminopropyl)triethoxysilane (APTES) or (3‐aminopropyl)phosphonic acid (APPA) to functionalize the NP surface with free amino‐groups. Then, the complementary functionalized NP set can be obtained from an aliquot of the first one, through the conversion of free surface amino groups to aldehydes by reaction with glutaraldehyde (GA). Several types of TiO2 NPs differing in size, shape, and specific surface area have been functionalized. Fourier‐transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), SEM/ energy‐dispersive X‐ray spectroscopy (EDS), XPS, Auger electron spectroscopy (AES), and Time‐of‐Flight (ToF)‐SIMS analyses have been carried out to evaluate the degree of functionalization, all the analytical methods employed demonstrating successful functionalization of TiO2 NP surface with APTES or APPA and GA.

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