Functionalisation of porous hydroxyapatite for bone substitutes

Meurice, Edwige; Leriche, Anne; Hornez, Jean‐Christophe; Bouchart, Franck; Rguiti, Emmanuelle; Boilet, Laurent; Descamps, M.; Cambier, F.

doi:10.1016/j.jeurceramsoc.2012.01.014

Cited by 28 publications

(11 citation statements)

References 10 publications

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“…Therefore, the spherical particles produced from slurries generally consist of agglomerates of the primary particles dispersed in the slurry, and their diameter is often a few orders of magnitude bigger than the diameter of the primary particles (Table 2). For example, 1mm particles can be obtained by drip-casting ( = droplet extrusion), 62 - 71 emulsification, 72 - 82 hydro-casting, 83 and by the lost-wax method 84 , 85 (Fig. 2).…”

Section: Methods To Produce Spherical Cap Particlesmentioning

confidence: 99%

“…With the exception of precipitation reactions, all production methods rely on the dispersion of the reagent (solution, slurry, paste, or solid) into another phase: a gas to form an aerosol, a liquid to form an emulsion, or a solid acting as a mold (lost-wax method 84 , 85 ). Whereas slurries have been used in all three dispersion approaches, solid reagents have only been dispersed in a gas (plasma melting 45 , 46 , 94 - 97 ).…”

Section: Methods To Produce Spherical Cap Particlesmentioning

confidence: 99%

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Synthesis of spherical calcium phosphate particles for dental and orthopedic applications

et al. 2013

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Calcium phosphate materials have been used increasingly in the past 40 years as bone graft substitutes in the dental and orthopedic fields. Accordingly, numerous fabrication methods have been proposed and used. However, the controlled production of spherical calcium phosphate particles remains a challenge. Since such particles are essential for the synthesis of pastes and cements delivered into the host bone by minimally-invasive approaches, the aim of the present document is to review their synthesis and applications. For that purpose, production methods were classified according to the used reagents (solutions, slurries, pastes, powders), dispersion media (gas, liquid, solid), dispersion tools (nozzle, propeller, sieve, mold), particle diameters of the end product (from 10 nm to 10 mm), and calcium phosphate phases. Low-temperature calcium phosphates such as monetite, brushite or octacalcium phosphate, as well as high-temperature calcium phosphates, such as hydroxyapatite, β-tricalcium phosphate or tetracalcium phosphate, were considered. More than a dozen production methods and over hundred scientific publications were discussed.

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Section: Methods To Produce Spherical Cap Particlesmentioning

confidence: 99%

Section: Methods To Produce Spherical Cap Particlesmentioning

confidence: 99%

Synthesis of spherical calcium phosphate particles for dental and orthopedic applications

et al. 2013

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“…In our study, samples with higher porosity levels showed more sustained antibacterial properties, and thus needs to be examined in other studies on implant related infections (Chai et al, 2007;Meurice et al, 2012).…”

Section: Discussionmentioning

confidence: 89%

Antibacterial Efficiency of Hydroxyapatite Biomaterials with Biodegradable Polylactic Acid and Polycaprolactone Polymers Saturated with Antibiotics / Bionoārdāmu Polimēru Saturošu Un Ar Antibiotiskajām Vielām Piesūcinātu Biomateriālu Antibakteriālās Efektivitātes Noteikšana

Kroiča¹,

Skadiņš²,

Šalma³

et al. 2016

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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# Corresponding author; Ingus.Skadins@rsu.lv Contributed by Modra MurovskaInfections continue to spread in all fields of medicine, and especially in the field of implant biomaterial surgery, and not only during the surgery, but also after surgery. Reducing the adhesion of bacteria could decrease the possibility of biomaterial-associated infections. Bacterial adhesion could be reduced by local antibiotic release from the biomaterial. In this in vitro study, hydroxyapatite biomaterials with antibiotics and biodegradable polymers were tested for their ability to reduce bacteria adhesion and biofilm development. This study examined the antibacterial efficiency of hydroxyapatite biomaterials with antibiotics and biodegradable polymers against Staphylococcus epidermidis and Pseudomonas aeruginosa. The study found that hydroxyapatite biomaterials with antibiotics and biodegradable polymers show longer antibacterial properties than hydroxyapatite biomaterials with antibiotics against both bacterial cultures. Therefore, the results of this study demonstrated that biomaterials that are coated with biodegradable polymers release antibiotics from biomaterial samples for a longer period of time and may be useful for reducing bacterial adhesion on orthopedic implants.

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“…Hydroxyapatite (HAp) and ␤-tricalcium phosphate (␤-TCP) are extensively used as potential bioceramics for both dental and orthopedic applications due to their close chemical similarity with the inorganic component of bone and tooth mineral [1]. HAp has received more attention as bone replacing materials in orthopedic surgery because of its inherent ability to bond with the hard tissue [2]. But it has a low resorption rate and bone growth occurs only at the interface [3].…”

Section: Introductionmentioning

confidence: 99%

Structural and chemical analysis of silica-doped β-TCP ceramic coatings on surgical grade 316L SS for possible biomedical application

Ananth

Shanmugam

Jose

et al. 2015

Journal of Asian Ceramic Societies

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Please cite this article in press as: K. Prem Ananth, et al., Structural and chemical analysis of silica-doped ␤-TCP ceramic coatings on surgical grade 316L SS for possible biomedical application, J. Asian Ceram. Soc. (2015), http://dx. a b s t r a c tWe have developed a novel approach to introduce silica-doped ␤-tricalcium phosphate (Si-␤-TCP) on 316L SS substrates for enhanced biological properties. Doping of ␤-TCP with silica loadings ranging from 0 to 8 mol% was carried out using chemical precipitation method. Si-␤-TCP powder was sintered at 800 • C followed by coating it on 316L SS substrate using electrophoretic deposition. The coated and uncoated samples were investigated by various characterization techniques such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM) and X-ray fluorescence spectroscopy (XRF). Biomineralization ability of the coatings was evaluated by immersing in simulated body fluid (SBF) solution for different number of days such as 7, 14, 21 and 28 days. The results obtained in our study have shown that the apatite formation ability was high for the 8 mol% of Si-␤-TCP. This will promote better biomineralization ability compared to the other coatings.

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Functionalisation of porous hydroxyapatite for bone substitutes

Cited by 28 publications

References 10 publications

Synthesis of spherical calcium phosphate particles for dental and orthopedic applications

Synthesis of spherical calcium phosphate particles for dental and orthopedic applications

Antibacterial Efficiency of Hydroxyapatite Biomaterials with Biodegradable Polylactic Acid and Polycaprolactone Polymers Saturated with Antibiotics / Bionoārdāmu Polimēru Saturošu Un Ar Antibiotiskajām Vielām Piesūcinātu Biomateriālu Antibakteriālās Efektivitātes Noteikšana

Structural and chemical analysis of silica-doped β-TCP ceramic coatings on surgical grade 316L SS for possible biomedical application

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