Functional vision with cataracts of different morphologies: Comparative study

Stifter, Eva; Sacu, Stefan; Weghaupt, Herbert

doi:10.1016/j.jcrs.2004.01.038

Cited by 35 publications

(32 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…12 It has been proposed that age-related lens sclerosis may play a role in this decrease. 13,14,15 One of the most comprehensive of these studies is that of Owsley et al, 16 which included 91 subjects. They observed decreased contrast sensitivity at high spatial frequencies but found no effect at lower frequencies in subjects over 40 years old; they also noted that small children had high contrast sensitivity at low frequencies, but low sensitivity at intermediate and high frequencies.…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Contrast Sensitivity in Healthy Individuals: A Pilot Study

Karatepe¹,

Köse²,

Eğrilmez³

2017

tjo

View full text Add to dashboard Cite

Objectives:To determine the demographic and ocular features affecting contrast sensitivity levels in healthy individuals.Materials and Methods:Seventy-four eyes of 37 subjects (7-65 years old) with refractive errors less than 1.0 diopter, no history of ocular surgery, and 20/20 visual acuity were included in the study. The participants were divided by age into three groups: group 1, 7-19 years, n=11; group 2, 20-49 years, n=15; and group 3, 50-65 years, n=11. All subjects underwent anterior and posterior segment evaluation, intraocular pressure measurements, refraction measurements, and clinical evaluation for strabismus. Contrast static test was performed using Metrovision MonPack 3 vision monitor system after measuring pupil diameter. Photopic and mesopic measurements were taken sequentially from right eyes, left eyes, and both eyes together.Results:Contrast sensitivity at intermediate and high spatial frequencies was lower with increasing age. Binocular measurements were better than monocular, and mesopic measurements were better than photopic measurements at all spatial frequencies. Contrast sensitivity at higher spatial frequency was lower with hyperopic refraction values.Conclusion:Increasing age, small pupil diameter, hyperopia, and photopic conditions were associated with lower contrast sensitivity in healthy individuals. Binocular contrast sensitivity measurements were better than monocular contrast sensitivity measurements in all conditions and spatial frequencies.

show abstract

Section: Discussionmentioning

confidence: 99%

Factors Affecting Contrast Sensitivity in Healthy Individuals: A Pilot Study

Karatepe¹,

Köse²,

Eğrilmez³

2017

tjo

View full text Add to dashboard Cite

show abstract

“…The mechanism of cataract induction involves the blockage of swelling-activated chloride channels in the lens,201, 202 and it is at least partly independent of the actions of tamoxifen on ERs 203,204. The increased risk of posterior subcapsular cataracts may be as high a factor of 4,169 which is important because posterior subcapsular cataracts tend to impair function more than other types of cataracts 205. This visual impairment may adversely affect cognitive test performance, even at a time when visual acuity is affected minimally 206…”

Section: Adjuvant Endocrine Therapymentioning

confidence: 99%

Breast Cancer Medications and Vision: Effects of Treatments for Early-stage Disease

Eisner¹,

Luoh²

2011

Current Eye Research

View full text Add to dashboard Cite

This review concerns the effects on vision and the eye of medications prescribed at three phases of treatment for women with early-stage breast cancer (BC): (1) adjuvant cytotoxic chemotherapy, (2) adjuvant endocrine therapy, and (3) symptomatic relief. The most common side effects of cytotoxic chemotherapy are epiphora and ocular surface irritation, which can be caused by any of several different regimens. Most notably, the taxane docetaxel can lead to epiphora by inducing canalicular stenosis. The selective-estrogen-receptor-modulator (SERM) tamoxifen, long the gold-standard adjuvant-endocrine-therapy for women with hormone-receptor-positive BC, increases the risk of posterior subcapsular cataract. Tamoxifen also affects the optic nerve head more often than previously thought, apparently by causing subclinical swelling within the first 2 years of use for women older than ∼50 years. Tamoxifen retinopathy is rare, but it can cause foveal cystoid spaces that are revealed with spectral-domain optical coherence tomography (OCT) and that may increase the risk for macular holes. Tamoxifen often alters the perceived color of flashed lights detected via short-wavelength-sensitive (SWS) cone response isolated psychophysically; these altered perceptions may reflect a neural-response sluggishness that becomes evident at ∼2 years of use. The aromatase inhibitor (AI) anastrozole affects perception similarly, but in an age-dependent manner suggesting that the change of estrogen activity towards lower levels is more important than the low estrogen activity itself. Based on analysis of OCT retinal thickness data, it is likely that anastrozole increases the tractional force between the vitreous and retina. Consequently, AI users, myopic AI users particularly, might be at increased risk for traction-related vision loss. Because bisphosphonates are sometimes prescribed to redress AI-induced bone loss, clinicians should be aware of their potential to cause scleritis and uveitis occasionally. We conclude by suggesting some avenues for future research into the visual and ocular effects of AIs, particularly as relates to assessment of cognitive function.

show abstract

“…17 Consequently, it has been suggested that VA is not the most appropriate tool to investigate the impact of symptomatic non-advanced cataract on visual function and experience, 11 and complementary and/or alternative techniques that have been investigated include CS, 18 glare disability (GD), 19 reading performance, 20 and functional visual difficulty assessed by various questionnaires. [21][22][23] Morphological and optical characteristics of lens opacification are also important, and can be assessed by various grading systems 24 and Scheimpflug photography, 25,26 respectively, and have the advantage of being independent of patient cooperation and ocular co-morbidity.…”

Section: Introductionmentioning

confidence: 99%

Psychophysical impact and optical and morphological characteristics of symptomatic non-advanced cataract

Charalampidou

Nolan

Loughman

et al. 2011

Eye

View full text Add to dashboard Cite

Purpose To investigate whether psychophysical, morphological, and/or optical characteristics of symptomatic non-advanced cataract are complementary to, or more appropriate than, visual acuity (VA) for the purposes of recording visual data that reflect subjective visual difficulty in patients with cataract that exhibit relative sparing of high contrast acuity (0.4 logarithm of minimal angle of resolution (logMAR) scale or better). Methods Eighty-two patients with symptomatic non-advanced cataract and no other ocular pathology were asked to complete a validated questionnaire, and to perform a series of visual function assessments including: corrected distance VA (CDVA); photopic and mesopic contrast sensitivity; photopic and mesopic glare disability (GD); reading acuity and reading speed; stereoacuity; and retinal sensitivity. Optical and morphological characteristics of the cataract were evaluated by lens optical density and by the Lens Opacities Classification System III, respectively. Correlations between questionnaire score and each of these measures were calculated. Results Statistically significant negative correlations were observed between the Rasch-scaled questionnaire score and mesopic GD (at 3 and 6 cycles per degree (cpd); r ¼ À0.396 (Po0.01) and À0.451 (Po0.05), respectively) and between the Rasch-scaled questionnaire score and photopic GD (at 3 and 6 cpd; r ¼ À0.328 (Po0.01) and À0.440 (Po0.01), respectively). Conclusion Symptomatic non-advanced cataract, in the presence of good CDVA, is associated with measurable subjective visual difficulty, best reflected in a decrease in mesopic and photopic GD (at medium spatial frequencies). CDVA does not reflect the patient's visual dissatisfaction in such cases.

show abstract

Functional vision with cataracts of different morphologies: Comparative study

Cited by 35 publications

References 29 publications

Factors Affecting Contrast Sensitivity in Healthy Individuals: A Pilot Study

Factors Affecting Contrast Sensitivity in Healthy Individuals: A Pilot Study

Breast Cancer Medications and Vision: Effects of Treatments for Early-stage Disease

Psychophysical impact and optical and morphological characteristics of symptomatic non-advanced cataract

Contact Info

Product

Resources

About