2022
DOI: 10.3389/fimmu.2022.973169
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Functional variant rs12614 in CFB confers a low risk of IgA nephropathy by attenuating complement alternative pathway activation in Han Chinese

Abstract: Activation of the alternative pathway (AP) of complement is thought to play an important role in Immunoglobin A nephropathy (IgAN). Our previous study showed that rs4151657 within the complement factor B (CFB) gene increased the risk of IgAN. The protein encoded by the CFB gene is an initial factor that promotes AP activation. The aim of this study was to investigate whether other variants of CFB confer susceptibility to IgAN and elucidate their potential roles in AP activation. A total of 1,350 patients with … Show more

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Cited by 3 publications
(1 citation statement)
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“…Some tissues, including the lower respiratory tract, are shielded from harm by proteolytic enzymes by this function. P00751 Complement factor B protein The complement alternative pathway includes complement factor B (CFB) [ 27 ]. It has a serine protease (SP) domain that, when activated, produces the catalytic activity of the C3 and C5 convertases found on the alternative pathway.…”
Section: Resultsmentioning
confidence: 99%
“…Some tissues, including the lower respiratory tract, are shielded from harm by proteolytic enzymes by this function. P00751 Complement factor B protein The complement alternative pathway includes complement factor B (CFB) [ 27 ]. It has a serine protease (SP) domain that, when activated, produces the catalytic activity of the C3 and C5 convertases found on the alternative pathway.…”
Section: Resultsmentioning
confidence: 99%