Functional variant in the 3’-untranslated region of toll-like receptor 4 is associated with nasopharyngeal carcinoma risk

Song, Chang; Chen, Li Zhen; Zhang, Ru Hua; Yu, Xinmiao; Zeng, Yi Xin

doi:10.4161/cbt.5.10.3304

Cited by 37 publications

(26 citation statements)

References 47 publications

(53 reference statements)

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“…Moreover, the risk of gastric carcinoma is increased by a functional polymorphism of TLR4 (Hold et al, 2007). Sequence variants of TLR3, 4 and 10 are associated with nasopharyngeal carcinoma risk (Song et al, 2006;Zhou et al, 2006;He et al, 2007a). Sequence variants of TLR2 increase the risk of gastric cancer.…”

Section: Tlr As a Positive Regulator Of Cancermentioning

confidence: 98%

Roles of toll-like receptors in Cancer: A double-edged sword for defense and offense

et al. 2012

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Toll-like receptors (TLRs) belong to a class of pattern-recognition receptors that play an important role in host defense against pathogens by recognizing a wide variety of pathogen-associated molecular patterns (PAMPs). Besides driving inflammatory responses, TLRs also regulate cell proliferation and survival by expanding useful immune cells and integrating inflammatory responses and tissue repair processes. TLR signaling, which is centrally involved in the initiation of both innate and adaptive immune responses, has been thought to be restricted to immune cells. However, recent studies have shown that functional TLRs are expressed not only on immune cells, but also on cancer cells, thus implicating a role of TLRs in tumor biology. Increasing bodies of evidence have suggested that TLRs act as a double-edged sword in cancer cells because uncontrolled TLR signaling provides a microenvironment that is necessary for tumor cells to proliferate and evade the immune response. Alternatively, TLRs can induce an antitumor immune response in order to inhibit tumor progression. In this review, we summarize the dual roles of TLRs in tumor cells and, more importantly, delve into the therapeutic potential of TLRs in the context of tumorigenesis.

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Section: Tlr As a Positive Regulator Of Cancermentioning

confidence: 98%

Roles of toll-like receptors in Cancer: A double-edged sword for defense and offense

et al. 2012

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“…However, some research reported that functional TLRs were also detected on tumor cells. 16,20 The signaling of TLR9 could obviously influence the survival of tumor cells. 16 But the exact effects and underlying mechanisms of functional TLRs expressed on tumor cells retain undefined.…”

Section: Discussionmentioning

confidence: 99%

Functional expression of TLR9 is associated to the metastatic potential of human lung cancer cell

Ren¹,

Wen²,

Liu³

et al. 2007

Cancer Biology & Therapy

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KeY WoRds TLR9, CpG oligonucleotide, 95D cells, metastasis AbbReviATions Research Paper Functional Expression of TLR9 is Associated to the Metastatic Potential of Human Lung Cancer CellFunctional Active Role of TLR9 on Tumor MetastasisAbsTRAcT CpG-oligonucleotides (CpG-ODN), which induce signaling through Toll-like receptor 9 (TLR9), are widely used as adjuvants in therapy against cancer. However, tumor cells express functional TLR9 were recently reported and the immune effect of CpG ODN on tumor cells remains unclear. Here we investigated the direct effects of CpG ODN on human tumor cell line 95D cells using flow cytometric analysis and Western blotting. We found strongly high expression of TLR9 in 95D cells. Stimulation of 95D cells with CpG ODN induced significantly elevated secretion of IL-1a and IL-8, as well as the expression of CXCR4, ICAM-1 and MMP-2. Furthermore, the invasion of 95D cells and TLR9 modifying 95C cells were significantly enhanced by stimulation of CpG ODN, which could be abrogated by inhibitory CpG ODN and chloroquine. These results suggest that functionally active TLR9 is expressed on human tumor cell lines, and may represent a novel insight on the role of TIL9 agonist used in tumor immunotherapy.

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“…Intriguingly, there is a functional SNP located 100 bp upstream of S03: rs41426344 was found to alter gene expression in luciferase-based reporter gene assays. 31,32 We genotyped this SNP for our African samples (n=602). It turned out that this SNP was monomorphic in our African samples.…”

Section: Discussionmentioning

confidence: 99%

Common polymorphisms in TLR4 gene associated with susceptibility to pulmonary tuberculosis in the Sudanese

Zaki

Leung

Yiu

et al. 2012

int j tuberc lung dis

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This is the Pre-Published Version.2 ABSTRACT SETTING: Host genetic risk factors influence the susceptibility to tuberculosis (TB). There is ample evidence supporting the involvement of toll-like receptor 4 (TLR4) in mycobacterial infection.OBJECTIVE: To study the relationship between the TLR4 gene and TB susceptibility in Sudanese.DESIGN: A case-control study was conducted by recruiting 207 patients with pulmonary TB and 395 healthy controls. Ten tag single nucleotide polymorphisms (SNPs) of the TLR4 gene were genotyped using restriction digestion or hybridization assays, and analyzed.RESULTS: The genotypes were in Hardy-Weinberg equilibrium. With Mantel-Haenszel tests controlled for gender, four SNPs showed significant differences between cases and controls even after correction of multiple comparisons by Bonferroni procedure. The Mantel-Haenszel estimates of allelic odds ratios for the high-risk alleles were 1.67 for rs1927911 (P=0.0001), 1.85 for rs5030725 (P=0.0008), 2.14 for rs7869402 (P=1.87e-07), and 2.31 for rs1927906 (P=1.23e-10). Haplotype analysis showed that rs1927911 and rs5030725 were in one haplotype block, and rs7869402 and rs1927906 were in another haplotype block. Conditional haplotype analysis suggests the presence of one causal variant downstream of a recombination hotspot at the 3' region of the TLR4 gene.CONCLUSION: This is the first study to show that common TLR4 polymorphisms are associated with TB susceptibility in a Sudanese population.(Abstract: 203 words) 3

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Functional variant in the 3’-untranslated region of toll-like receptor 4 is associated with nasopharyngeal carcinoma risk

Cited by 37 publications

References 47 publications

Roles of toll-like receptors in Cancer: A double-edged sword for defense and offense

Roles of toll-like receptors in Cancer: A double-edged sword for defense and offense

Functional expression of TLR9 is associated to the metastatic potential of human lung cancer cell

Common polymorphisms in TLR4 gene associated with susceptibility to pulmonary tuberculosis in the Sudanese

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