Functional Tricuspid Regurgitation in Patients With Chronic Mitral Regurgitation: An Evidence-Based Narrative Review

Patel, Kinjal; Kumar, Nakul; Neuburger, Peter J.; Desai, Ronak; Krishnan, Sandeep

doi:10.1053/j.jvca.2021.05.032

Cited by 2 publications

(2 citation statements)

References 68 publications

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“…The progressive RV dilatation, promoted by the relative lack in muscular tissue of RV, due to the increased afterload, is triggered by PH. Different studies have demonstrated the role of PH as a determinant of FTR severity; in a vicious circle, the chronic pressure and volume overload increase leaflets tethering, ultimately worsening TR ( 18 ).…”

Section: Pathogenesis Of Ftrmentioning

confidence: 99%

Functional Tricuspid Regurgitation: Behind the Scenes of a Long-Time Neglected Disease

Vinciguerra

Sitges

Pomar

et al. 2022

Front. Cardiovasc. Med.

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Severe tricuspid valve regurgitation has been for a long time a neglected valve disease, which has only recently attracted an increasing interest due to the notable negative impact on the prognosis of patients with cardiovascular disease. It is estimated that around 90% of tricuspid regurgitation is diagnosed as “functional” and mostly secondary to a primary left-sided heart disease and, therefore, has been usually interpreted as a benign condition that did not require a surgical management. Nevertheless, the persistence of severe tricuspid regurgitation after left-sided surgical correction of a valve disease, particularly mitral valve surgery, has been associated to adverse outcomes, worsening of the quality of life, and a significant increase in mortality rate. Similar results have been found when the impact of isolated severe tricuspid regurgitation has been studied. Current knowledge is shifting the “functional” categorization toward a more complex and detailed pathophysiological classification, identifying various phenotypes with completely different etiology, natural history and, potentially, an invasive management. The aim of this review is to offer a comprehensive guide for clinicians and surgeons with a systematic description of “functional” tricuspid regurgitation subtypes, an analysis centered on the effectiveness of existing surgical techniques and a focus on the emergent percutaneous procedures. This latter may be an attractive alternative to a standard surgical approach in patients with high-operative risk or isolated tricuspid regurgitation.

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Section: Pathogenesis Of Ftrmentioning

confidence: 99%

Functional Tricuspid Regurgitation: Behind the Scenes of a Long-Time Neglected Disease

Vinciguerra

Sitges

Pomar

et al. 2022

Front. Cardiovasc. Med.

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show abstract

“…Indeed, recent data largely have supported concomitant tricuspid valve repair at the time of mitral surgery. 12 However, there is lack of data to help clinicians differentiate cases of non-severe TR that will evolve favorably or unfavorably after left heart surgery. 3 Thus, we sought to address these knowledge gaps by determining the prognostic impact of functional TR in a large contemporary cohort of patients undergoing diverse cardiac surgeries, examining the effect-modifying role of patient characteristics in identifying groups of patients in whom TR confers a greater risk of adverse outcomes.…”

mentioning

confidence: 99%

Association Between Functional Tricuspid Regurgitation and Mortality Following Cardiac Surgery

Tan,

Mullie,

Flynn

et al. 2023

JACC: Advances

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Functional Tricuspid Regurgitation in Patients With Chronic Mitral Regurgitation: An Evidence-Based Narrative Review

Cited by 2 publications

References 68 publications

Functional Tricuspid Regurgitation: Behind the Scenes of a Long-Time Neglected Disease

Functional Tricuspid Regurgitation: Behind the Scenes of a Long-Time Neglected Disease

Association Between Functional Tricuspid Regurgitation and Mortality Following Cardiac Surgery

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