Functional topography of the right inferior parietal lobule structured by anatomical connectivity profiles

Abstract

The nature of the relationship between structure and function is a fundamental question in neuroscience, especially at the macroscopic neuroimaging level. Although mounting studies have revealed that functional connectivity reflects structural connectivity, whether similar structural and functional connectivity patterns can reveal corresponding similarities in the structural and functional topography remains an open problem. In our current study, we used the right inferior parietal lobule (RIPL), which has been demonstrated to have similar anatomical and functional connectivity patterns at the subregional level, to directly test the hypothesis that similar structural and functional connectivity patterns can inform the corresponding topography of this area. In addition, since the association between the RIPL regions and particular functions and networks is still largely unknown, post-hoc functional characterizations and connectivity analyses were performed to identify the main functions and cortical networks in which each subregion participated. Anatomical and functional connectivity-based parcellations of the RIPL have consistently identified five subregions. Our functional characterization using meta-analysis-based behavioral and connectivity analyses revealed that the two anterior subregions (Cl1 and Cl2) primarily participate in interoception and execution, respectively; whereas the posterior subregion (Cl3) in the SMG primarily participates in attention and action inhibition. The two posterior subregions (Cl4, Cl5) in the AG were primarily involved in social cognition and spatial cognition, respectively. These results indicated that similar anatomical and functional connectivity patterns of the RIPL are reflected in corresponding structural and functional topographies. The identified cortical connectivity and functional characterization of each subregion may facilitate RIPL-related clinical research. Hum Brain Mapp 37:4316-4332, 2016. © 2016 Wiley Periodicals, Inc.

Multimodal connectivity‐based parcellation reveals a shell‐core dichotomy of the human nucleus accumbens

“…Barbas and Rempel‐Clower, ; Fan et al, ; van den Heuvel et al, ]. However, the gross correspondence of the parcellation results based on different features or even sub‐features, for example, different immunohistochemical markers or different connection types in this study, still remains unclear, weaker‐ or even noncorresponding results exist in many studies [Fan et al, ; Liu et al, ; Moerel et al, ; Wang et al, ]. For example, both left and right inferior parietal lobule (LIPL/RIPL) were parcellated into seven regional cytoarchitectonic subregions [Caspers et al, ], but three receptor distributed subregions [Caspers et al, ] and five tractographically defined subregions [Mars et al, ; Wang et al, ].…”

“…To address these issues, three CBP schemes based on probabilistic diffusion tractography (PDT‐CBP) [Fan et al, ], resting‐state functional connectivity (rsFC‐CBP) [Wang et al, ], and meta‐analytic connectivity modeling (MACM‐CBP) [Ray et al, ] were used to parcellate the NAc. For the former two schemes, we used high‐quality MRI data from the Human Connectome Project (HCP) [Sotiropoulos et al, ; Van Essen et al, ] and applied mixed registration methods.…”

Specifying the brain anatomy underlying temporo-parietal junction activations for theory of mind: A review using probabilistic atlases from different imaging modalities

“…With respect to connectivity, studies showed that single‐subject connectivity patterns from diffusion weighted imaging [Osher et al, ; Saygin et al, ] and resting‐state fMRI [Tavor et al, ] predict if an area is activated during task‐based fMRI on a voxel‐by‐voxel level; this finding that was replicated across several cognitive (task) domains. Connectivity‐based parcellations have been found recently not only within the TPJ [Bzdok et al, ; Mars et al, ], but also within several other areas of the social brain, such as the medial prefrontal cortex [Bzdok et al, ; Eickhoff et al, ; Neubert et al, ; Sallet et al, ], posterior medial cortex/precuneus [Bzdok et al, ; Margulies et al, ], and the inferior parietal lobule [Bzdok et al, ; Wang, et al, ].…”

Differences between child and adult large‐scale functional brain networks for reading tasks

“…Moreover, it has been reported to be a critical region for spatial attention and play a vital role in fluent reading (Wei et al, ). Inferior frontal gyrus and precentral gyrus have been reported to be activated in various phonological and speech processing tasks (Cao et al, ; Price, ; Zhang, Shu, Zhou, Wang, & Li, ), with the former associated with phonological retrieval (Liu et al, ) and the latter associated with speech articulation (Fan, Mccandliss, Fossella, Flombaum, & Posner, ; Liu et al, ; Wang et al, ). Superior frontal gyrus is thought to be a part of cognitive execution network, involved in working memory and attention (Li et al, ).…”