Functional Therapeutic Strategies Used in Different Stages of Alzheimer’s Disease—A Systematic Review

Olczak, Anna; Truszczyńska-Baszak, Aleksandra; Stępień, Adam; Górecki, Krzysztof

doi:10.3390/ijerph191811769

Cited by 3 publications

References 34 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Alzheimer's disease biomarker burden in primary motor cortices is associated with poorer dexterity performance

Gupta,

Ma,

Kohli

et al. 2024

Alzheimer's & Dementia

View full text Add to dashboard Cite

INTRODUCTIONMotor function has correlated with longevity and functionality; however, there is limited research on those with Alzheimer's disease (AD). We studied the association between motor functionality and AD pathology in primary motor and medial temporal cortices.METHODSA total of 206 participants with a clinical diagnosis of cognitively healthy, AD, or mild cognitive impairment (MCI) underwent imaging and motor assessment. Linear regressions and analyses of variance were applied to test the prediction from AD imaging biomarkers to motor performance and the diagnosis group differences in motor performance.RESULTSIncreased neurodegeneration was associated with worsening dexterity and lower walking speed, and increased amyloid and tau were associated with worsening dexterity. AD and MCI participants had lower motor performance than the cognitively healthy participants.DISCUSSIONIncreased AD pathology is associated with worsening dexterity performance. The decline in dexterity in those with AD pathology may offer an opportunity for non‐pharmacological therapy intervention.Highlights Noted worsening dexterity performance was associated with greater Alzheimer's disease (AD) pathology (tau, amyloid beta, and neurodegeneration) in primary motor cortices. Similarly, increased neurodegeneration and tau pathology in parahippocampal, hippocampal, and entorhinal cortices is associated with worsening dexterity performance. Motor performance declined in those with clinical and preclinical AD among an array of motor assessments.

show abstract