Functional state of gepatobiliary system of children with obesity

Diagnostic significance of biochemical indicators of liver fibrogenesis in adolescents with obesity

“…Prolonged increase in the level of free fatty acids in hepatocytes causes mitochondrial dysfunction, which contributes to the microsomal oxidation of lipids by the cytochrome P450 system with the formation of reactive oxygen species [5][6][7]. The oxidative stress, the "second blow", occurs.…”