Functional state of erythrocytes in chronic obstructive pulmonary disease on the background of COVID-19, ways of correction

Todoriko, Lilia; Gumeniuk, Mykola; Semianiv, Ihor; Sprynsian, Tania; Denisov, Оlexandr

doi:10.1183/13993003.congress-2021.pa872

Cited by 1 publication

(4 citation statements)

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“…55 Indeed, reduction of erythrocyte deformability is correlated with chronic obstructive pulmonary diseases promotes development of hyperviscosity syndrome with induction of coagulation system and thrombotic disorders. 56 Therefore, patients with chronic obstructive pulmonary diseases are at high risk for development of systemic complication during SARS-CoV-2 infection. 56 These verdicts suggest that erythrocyte deformability is reduced in viral infections including SARS-CoV-2 infection due to inflammatory and oxidative stress disorders with induction of COVID-19 complications.…”

Section: Erythrocyte Deformability In Sars-cov-2 Infectionmentioning

confidence: 99%

“…56 Therefore, patients with chronic obstructive pulmonary diseases are at high risk for development of systemic complication during SARS-CoV-2 infection. 56 These verdicts suggest that erythrocyte deformability is reduced in viral infections including SARS-CoV-2 infection due to inflammatory and oxidative stress disorders with induction of COVID-19 complications.…”

Section: Erythrocyte Deformability In Sars-cov-2 Infectionmentioning

confidence: 99%

“…Indeed, reduction of erythrocyte deformability is correlated with chronic obstructive pulmonary diseases promotes development of hyperviscosity syndrome with induction of coagulation system and thrombotic disorders. 56 Therefore, patients with chronic obstructive pulmonary diseases are at high risk for development of systemic complication during SARS-CoV-2 infection. 56 …”

Section: Introductionmentioning

confidence: 99%

“… 56 Therefore, patients with chronic obstructive pulmonary diseases are at high risk for development of systemic complication during SARS-CoV-2 infection. 56 …”

Section: Introductionmentioning

confidence: 99%

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COVID-19 and erythrocrine function: The roller coaster and danger

Al-Kuraishy

Al-Gareeb

Onohuean

et al. 2022

Int J Immunopathol Pharmacol

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Erythrocrine function refers to erythrocytes’ ability to synthesize and release active signaling molecules such as ATP and nitric oxide (NO). Erythrocyte NO regulates its deformability and increases its perfusion and circulation that prevent tissue hypoxia. Recently, there is a connotation between SARS-CoV-2 infection and erythrocrine function due to alteration in the release of NO and ATP from erythrocytes. SARS-CoV-2 binds erythrocyte band3 protein, which has a similar characteristic of ACE2, leading to alteration of erythrocyte physiology like oxygen transport with development of hypoxia. Similarly, SARS-CoV-2 infection activates erythrocyte protein kinase C alpha (PKC-α), causing significant changes in the erythrocyte functions. The erythrocytes can bind SARS-CoV-2 and its active particles with subsequent virus delivery to the liver and spleen macrophages. Thus, the erythrocytes act as elimination for SARS-CoV-2 in COVID-19. Moreover, the erythrocyte stored, release sphingosine-1 phosphate (S1P) improves endothelial and regulates lymphocyte functions. SARS-CoV-2 ORF8 protein binds the porphyrin part of hemoglobin heme at the β1 chain, causing hemolysis and dysfunctional hemoglobin to reduce oxygen-carrying capacity. In conclusion, SARS-CoV-2 infection and associated pro-inflammatory disorders lead to abnormal erythrocrine function with subsequent inflammatory complications and endothelial dysfunction due to deficiency of protective released molecules (NO, G1P, and ATP) from functional erythrocytes. In vitro, preclinical, and clinical studies are mandatory in this regard.

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Section: Erythrocyte Deformability In Sars-cov-2 Infectionmentioning

confidence: 99%

Section: Erythrocyte Deformability In Sars-cov-2 Infectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“… 56 Therefore, patients with chronic obstructive pulmonary diseases are at high risk for development of systemic complication during SARS-CoV-2 infection. 56 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations