Functional Specialization of Olfactory Glomeruli in a Moth

Hansson, Bill S.; Ljungberg, Håkan; Hallberg, Eric; Löfstedt, Christer

doi:10.1126/science.1598574

Cited by 229 publications

(147 citation statements)

References 12 publications

Supporting

Mentioning

140

Contrasting

Unclassified

Order By: Relevance

“…The population of ORNs in the pheromone subsystem (~10,000) converges onto a smaller number of central neurons (~100, Homberg et al, 1988). In particular, the ORNs sensitive to the major component of the pheromone blend, the most common in the moth antenna, project to a single glomerulus of the MGC, the cumulus (Hansson et al, 1992). The pheromone subsystem of male moths shares all major properties of the generalist olfactory system of both insects and vertebrates, yet in a form well amenable to investigations with well-characterized ligands, highly specific receptors, and a large number of specialized, identical and identifiable ORNs.…”

Section: Introductionmentioning

confidence: 99%

Modelling the signal delivered by a population of first-order neurons in a moth olfactory system

Grémiaux¹,

Nowotny²,

Martinez³

et al. 2012

Brain Research

View full text Add to dashboard Cite

(2012) Modelling the signal delivered by a population of first-order neurons in a moth olfactory system. Brain Research, 1434. pp. 123-135. ISSN 0006-8993 This version is available from Sussex Research Online: http://sro.sussex.ac.uk/38437/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way.Grémiaux et al. Highlights > Odour intensity coding in a whole population of moth receptor neurons was modelled. > Frequency (spikes per second) and latency of the first spike were analyzed > The model accounts for the statistical distributions of frequencies and latencies. > The same dose-frequency relation applies at the single cell and population levels. > Predictions based on a biophysical model of frog olfactory neurons are confirmed. Abstract.A statistical model of the population of first-order olfactory receptor neurons (ORNs) is proposed and analysed. It describes the relationship between stimulus intensity (odour concentration) and coding variables such as rate and latency of the population of several thousand sex-pheromone sensitive ORNs in male moths. Although these neurons likely express the same olfactory receptor, they exhibit, at any concentration, a relatively large heterogeneity of responses in both peak firing frequency and latency of the first action potential fired after stimulus onset. The stochastic model is defined by a multivariate distribution of six model parameters that describe the dependence of the peak firing rate and the latency on the stimulus dose. These six parameters and their mutual linear correlations were estimated from experiments in single ORNs and included in the multidimensional model distribution. The model is utilized to reconstruct the peak firing rate and latency of the message sent to the brain by the whole ORN population at different stimulus intensities and to establish their main qualitative and quantitative properties. Finally, these properties are shown to be in agreement with those found previously in a vertebrate ORN population.

show abstract

Section: Introductionmentioning

confidence: 99%

Modelling the signal delivered by a population of first-order neurons in a moth olfactory system

Grémiaux¹,

Nowotny²,

Martinez³

et al. 2012

Brain Research

View full text Add to dashboard Cite

show abstract

“…The macroglomerular complex (MGC), a structure of enlarged glomeruli present only in the male AL, processes specifically sex pheromone information (for reviews see Mustaparta, 1996;Anton and Homberg, 1999;Hansson and Christensen, 1999). Each ORN type responding to one pheromone component projects to one MGC glomerulus in several moth species (Hansson et al, 1992;Ochieng' et al, 1995;Todd et al, 1995;Berg et al, 1998). By contrast, the representation within glomeruli that process non-pheromone odours is less evident.…”

mentioning

confidence: 99%

Three-dimensional antennal lobe atlas of male and female moths, Lobesia botrana (Lepidoptera: Tortricidae) and glomerular representation of plant volatiles in females

Masante-Roca

Gadenne

Anton

2005

Journal of Experimental Biology

View full text Add to dashboard Cite

Spatiotemporal odour coding is thought to be linked closely with the specific glomerular anatomy of the primary olfactory centre. In most insects the number of the glomeruli within the antennal lobe is limited to fewer than 100, allowing their individual identification. In the grapevine moth, Lobesia botrana, a map of the antennal lobe glomeruli was reconstructed three-dimensionally, by comparing three different brains in males and females. The map of the antennal lobe of females served then as a basis to identify glomeruli containing dendritic arborisations of 14 physiologically characterised projection neurons. Projection neurons responding to the same plant compound did not always arborise in the same glomerulus and some neurons arborising in the same glomerulus responded to different compounds. Different zones of target glomeruli were, however, identified when pooling all neurons responding to one of two different compounds respectively (α-farnesene and nonatriene). All identified glomeruli of specifically responding projection neurons were situated close to the anterior surface of the antennal lobe. One broadly responding projection neuron arborised in a more posteriorly situated glomerulus. A local interneuron responding to only one compound was arborising densely in a neighbouring glomerulus and had sparse branches in all other glomeruli. These results are discussed with respect to plant odour processing and structure-function relations in antennal lobe neurons. The 3D AL atlas will, in the future, also be used to obtain a better understanding of coding mechanisms of grapevine odours in this pest insect.

show abstract

“…In phylogenetically diverse species, individual olfactory sensory neurons (OSNs) generally express a single OR (Fuss and Ray, 2009), which is the primary determinant of odor response specificity. The axons of OSNs expressing the same receptor converge onto segregated regions of neuropil called glomeruli in the olfactory bulb (or antennal lobe in insects) (Hansson et al, 1992;Mombaerts et al, 1996;Zou et al, 2009). Here, OSNs synapse with projection neurons (PNs) that transmit odor-evoked signals to higher brain regions (Mori et al, 1999;Masse et al, 2009), as well as with local interneurons (LNs) that modulate OSN input and PN output activity within and between glomeruli (Christensen et al, 1993;Wachowiak and Shipley, 2006;Chou et al, 2010b).…”

Section: Introductionmentioning

confidence: 99%

Complementary Function and Integrated Wiring of the Evolutionarily DistinctDrosophilaOlfactory Subsystems

Silbering¹,

Rytz²,

Grosjean³

et al. 2011

J. Neurosci.

456

749

View full text Add to dashboard Cite

To sense myriad environmental odors, animals have evolved multiple, large families of divergent olfactory receptors. How and why distinct receptor repertoires and their associated circuits are functionally and anatomically integrated is essentially unknown. We have addressed these questions through comprehensive comparative analysis of the Drosophila olfactory subsystems that express the ionotropic receptors (IRs) and odorant receptors (ORs). We identify ligands for most IR neuron classes, revealing their specificity for select amines and acids, which complements the broader tuning of ORs for esters and alcohols. IR and OR sensory neurons exhibit glomerular convergence in segregated, although interconnected, zones of the primary olfactory center, but these circuits are extensively interdigitated in higher brain regions. Consistently, behavioral responses to odors arise from an interplay between IR-and OR-dependent pathways. We integrate knowledge on the different phylogenetic and developmental properties of these receptors and circuits to propose models for the functional contributions and evolution of these distinct olfactory subsystems.

show abstract

Functional Specialization of Olfactory Glomeruli in a Moth

Cited by 229 publications

References 12 publications

Modelling the signal delivered by a population of first-order neurons in a moth olfactory system

Modelling the signal delivered by a population of first-order neurons in a moth olfactory system

Three-dimensional antennal lobe atlas of male and female moths, Lobesia botrana (Lepidoptera: Tortricidae) and glomerular representation of plant volatiles in females

Complementary Function and Integrated Wiring of the Evolutionarily DistinctDrosophilaOlfactory Subsystems

Contact Info

Product

Resources

About