Functional Significance of Transient Receptor Potential Channels in Vascular Function

Earley, Scott; Brayden, Joseph E.; Reading, Stacey

doi:10.1201/9781420005844.ch26

Cited by 10 publications

(10 citation statements)

References 67 publications

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“…Mutations of putative ATP‐binding sites on TRPM4 abolish this effect, indicating that prevention of Ca 2+ ‐dependent inactivation is associated with direct binding of ATP to the channel . In a similar manner, heat shifts the voltage‐dependent activation curve for TRPM4 ( Q 10 = −5.6 ± 0.5 mV /°C) , a phenomenon also observed in other thermosensitive TRP channels . Modulation of the monovalent cation conductance through TRPM4 by voltage, adenine nucleotides, phospholipids, and heat and dependence on intracellular Ca 2+ for activation are consistent with NSC Ca channels previously described in many cell types, suggesting the identity of these channels as TRPM4.…”

Section: Trpm4supporting

confidence: 67%

Regulation of Cerebral Artery Smooth Muscle Membrane Potential by Ca²⁺‐Activated Cation Channels

Gonzales

Earley

2013

Microcirculation

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Arterial tone is dependent on the depolarizing and hyperpolarizing currents regulating membrane potential and governing the influx of Ca2+ needed for smooth muscle contraction. Several ion channels have been proposed to contribute to membrane depolarization, but the underlying molecular mechanisms are not fully understood. In this review, we will discuss the historical and physiological significance of the Ca2+-activated cation channel, TRPM4, in regulating membrane potential of cerebral artery smooth muscle cells. As a member of the recently described transient receptor potential super family of ion channels, TRPM4 possesses the biophysical properties and upstream cellular signaling and regulatory pathways that establish it as a major physiological player in smooth muscle membrane depolarization.

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Section: Trpm4supporting

confidence: 67%

Regulation of Cerebral Artery Smooth Muscle Membrane Potential by Ca²⁺‐Activated Cation Channels

Gonzales

Earley

2013

Microcirculation

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“…The TRPC1 and TRPC6 are two widely expressed TRPC isoforms implicated in VSMC receptor‐operated cation channel (ROCC) and/or store‐operated cation channel (SOCC) currents (Putney , Earley et al . ). The results revealed significantly enhanced mRNA levels for TRPC1 and TRPC6 in MCAs from rats subjected to ischaemia compared to sham‐operated rats, whereas no significant changes were observed in the VDCC or IP 3 R (Fig.…”

Section: Resultsmentioning

confidence: 97%

“…In the vasculature, TRPC1 and TRPC6 are two commonly expressed TRP channels in the SMC, implicated in ROCC and SOCC currents, mediating vasoconstriction upon stimulation of G‐protein‐coupled receptor activation (Putney , Earley et al . ). Moreover, TRPC1 and TRPC6 have been described to participate in stretch‐activated Ca 2+ channel (SAC) activation, stimulated by mechanical stress and mechanosensors via GPCR‐induced PLC activation (Spassova et al .…”

Section: Discussionmentioning

confidence: 97%

Cerebrovascular endothelin-1 hyper-reactivity is associated with transient receptor potential canonical channels 1 and 6 activation and delayed cerebral hypoperfusion after forebrain ischaemia in rats

et al. 2015

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“…Though, notably, increased [Ca 2+ ] i can be promoted by activation of Ca 2+ release channels, including ryanodine receptors and inositol 1,4,5-trisphosphate receptors on the SR, and also via transient receptor potential (TRP) channels (Jackson, 2000;Parekh & Putney, 2005;Earley et al, 2007;Gonzalez-Cobos & Trebak, 2010). There is evidence to suggest that high BP can modulate activation of calcium channels via changes in their expression level or by affecting their functional ionic conductance (Stekiel et al, 1986;Pesic et al, 2004).…”

Section: Mechanisms Controlling Arterial Contractility; Role Of Intramentioning

confidence: 99%

Plasma membrane calcium ATPases (PMCAs) as potential targets for the treatment of essential hypertension

Little

Cartwright

Neyses

et al. 2016

Pharmacology & Therapeutics

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The incidence of hypertension, the major modifiable risk factor for cardiovascular disease, is increasing. Thus, there is a pressing need for the development of new and more effective strategies to prevent and treat hypertension. Development of these relies on a continued evolution of our understanding of the mechanisms which control blood pressure (BP). Resistance arteries are important in the regulation of total peripheral resistance and BP; changes in their structure and function are strongly associated with hypertension. Anti-hypertensives which both reduce BP and reverse changes in resistance arterial structure reduce cardiovascular risk more than therapies which reduce BP alone. Hence, identification of novel potential vascular targets which modify BP is important. Hypertension is a multifactorial disorder which may include a genetic component. Genome wide association studies have identified ATP2B1, encoding the calcium pump plasma membrane calcium ATPase 1 (PMCA1), as having a strong association with BP and hypertension. Knockdown or reduced PMCA1 expression in mice has confirmed a physiological role for PMCA1 in BP and resistance arterial regulation. Altered expression or inhibition of PMCA4 has also been shown to modulate these parameters. The mechanisms whereby PMCA1 and 4 can modulate vascular function remain to be fully elucidated but may involve regulation of intracellular calcium homeostasis and/or comprise a structural role. However, clear physiological links between PMCA and BP, coupled with experimental studies directly linking PMCA1 and 4 to changes in BP and arterial function, suggest that they may be important targets for the development of new pharmacological modulators of BP.

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Functional Significance of Transient Receptor Potential Channels in Vascular Function

Cited by 10 publications

References 67 publications

Regulation of Cerebral Artery Smooth Muscle Membrane Potential by Ca²⁺‐Activated Cation Channels

Regulation of Cerebral Artery Smooth Muscle Membrane Potential by Ca²⁺‐Activated Cation Channels

Cerebrovascular endothelin-1 hyper-reactivity is associated with transient receptor potential canonical channels 1 and 6 activation and delayed cerebral hypoperfusion after forebrain ischaemia in rats

Plasma membrane calcium ATPases (PMCAs) as potential targets for the treatment of essential hypertension

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Functional Significance of Transient Receptor Potential Channels in Vascular Function

Cited by 10 publications

References 67 publications

Regulation of Cerebral Artery Smooth Muscle Membrane Potential by Ca2+‐Activated Cation Channels

Regulation of Cerebral Artery Smooth Muscle Membrane Potential by Ca2+‐Activated Cation Channels

Cerebrovascular endothelin-1 hyper-reactivity is associated with transient receptor potential canonical channels 1 and 6 activation and delayed cerebral hypoperfusion after forebrain ischaemia in rats

Plasma membrane calcium ATPases (PMCAs) as potential targets for the treatment of essential hypertension

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Product

Resources

About

Regulation of Cerebral Artery Smooth Muscle Membrane Potential by Ca²⁺‐Activated Cation Channels

Regulation of Cerebral Artery Smooth Muscle Membrane Potential by Ca²⁺‐Activated Cation Channels