Functional significance of cortical NMDA receptors in somatosensory information processing

Lo, Fu‐Sun; Akkentli, Fatih; Tsytsarev, Vassiliy; Erzurumlu, Reha S.

doi:10.1152/jn.00052.2013

Cited by 20 publications

(26 citation statements)

References 43 publications

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“…The voltage-sensitive dye spread along the mediolateral and dorsoventral axes of the neocortex. It was shown 27 that the voltage-sensitive dye RH-1691 loading extended across all cortical layers. It is important to note that in the imaging experiments we do not have real depth resolution.…”

Section: Discussionmentioning

confidence: 99%

“…Animals were anesthetized with urethane (i.p. 1.5 mg/ g) 27 ; the head was shaved and placed in a stereotaxic frame. After that about 4£4 mm cranial window was made over the left parietal cortex by the dental drill.…”

Section: Methodsmentioning

confidence: 99%

“…At the start of each optical recording, a gray-scale image of the cortical surface was obtained and then moved down 300 mm to the region of interest (ROI). 27,43 Each experimental session consisted of 375 trials, 500 frames per trial, with the stimulus (whisker C2 deflection) presented at the 300th frame, one trial per stimulus. The inter-trial interval was 12 sec.…”

Section: Methodsmentioning

confidence: 99%

“…This technique has yielded revolutionary results when applied to the somatosensory systems since it is based on the direct monitoring of the neural activity. 27,43 . Other types of the optical imaging allow us to study spatiotemporal features of the neural pools in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Study of the cortical representation of whisker frequency selectivity using voltage-sensitive dye optical imaging

et al. 2016

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The facial whiskers of rodents act as a high-resolution tactile apparatus that allow the animal to detect the finest details of its environment. Previously it was shown that whisker-sensitive neurons in the somatosensory cortex show frequency selectivity to small amplitude stimuli, An intravital voltage-sensitive dye optical imaging (VSDi) method in combination with the different frequency whisker stimulation was used in order to visualize neural activity in the mice somatosensory cortex in response to the stimulation of a single whisker by different frequencies. Using the intravital voltage-sensitive dye optical imaging (VSDi) method in combination with the different frequency whisker stimulation we visualized neural activity in the mice somatosensory cortex in response to the stimulation of a single whisker by different frequencies. We found that whisker stimuli with different frequencies led to different optical signals in the barrel field. Our results provide evidence that different neurons of the barrel cortex have different frequency preferences. This supports prior research that whisker deflections cause responses in cortical neurons within the barrel field according to the frequency of the stimulation. Many studies of the whisker frequency selectivity were performed using unit recording but to map spatial organization, imaging methods are essential. In the work described in the present paper, we take a serious step toward detailed functional mapping of the somatosensory cortex using VSDi. To our knowledge, this is the first demonstration of whisker frequency sensitivity and selectivity of barrel cortex neurons with optical imaging methods.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Study of the cortical representation of whisker frequency selectivity using voltage-sensitive dye optical imaging

et al. 2016

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“…In the PrV, ION transection results in a lack of orientation of dendritic trees of barrelette cells [22], while the same change in dendritic trees of barrelette cells is present in the PrV of NR1 subunit knock down mice [84]. In addition, ION transection leads to an increase of MII in the PrV of rats [33], while cortex-specific knockout of NR1 subunit in mice show similar increase of MII in layer 4 of barrel cortex [85]. These findings suggest that NMDAR-mediated activity is involved in dendrite branching and synaptogenesis.…”

Section: Discussionmentioning

confidence: 99%

Sensory Activity-Dependent and Sensory Activity-Independent Properties of the Developing Rodent Trigeminal Principal Nucleus

Erzurumlu²

2016

Dev Neurosci

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The whisker-sensory trigeminal central pathway of rodents is an established model for studies of activity-dependent neural plasticity. The first relay station of the pathway is the trigeminal principal nucleus (PrV), the ventral part of which receives sensory inputs mainly from the infraorbital branch of the maxillary trigeminal nerve (ION). Whisker-sensory afferents play an important role in the development of the morphological and physiological properties of PrV neurons. In neonates, deafferentation by ION transection leads to the disruption of whisker-related neural patterns (barrelettes) and cell death within a specific time window (critical period), as revealed by morphological studies. Whisker-sensory inputs control synaptic elimination, postsynaptic AMPA receptor trafficking, astrocyte-mediated synaptogenesis, and receptive-field characteristics of PrV cells, without a postnatal critical period. Sensory activity-dependent synaptic plasticity requires the activation of NMDA receptors and involves the participation of glia. However, the basic physiological properties of PrV neurons, such as cell type-specific ion channels, presynaptic terminal function, postsynaptic NMDA receptor subunit composition, and formation of the inhibitory circuitry, are independent of sensory inputs. Therefore, the first relay station of the whisker sensation is largely mature-like and functional at birth. Delineation of activity-dependent and activity-independent features of the postnatal PrV is important for understanding the development and functional characteristics of downstream trigeminal stations in the thalamus and neocortex. This mini review focuses on such features of the developing rodent PrV.

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Functional significance of cortical NMDA receptors in somatosensory information processing

Abstract: Lo FS, Akkentli F, Tsytsarev V, Erzurumlu RS. Functional significance of cortical NMDA receptors in somatosensory information processing.

Cited by 20 publications

References 43 publications

Study of the cortical representation of whisker frequency selectivity using voltage-sensitive dye optical imaging

Study of the cortical representation of whisker frequency selectivity using voltage-sensitive dye optical imaging

Sensory Activity-Dependent and Sensory Activity-Independent Properties of the Developing Rodent Trigeminal Principal Nucleus

Golgi polarity shift instructs dendritic refinement in the neonatal cortex by mediating NMDA receptor signaling

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