2018
DOI: 10.1080/15476286.2018.1435248
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Functional sequestration of microRNA-122 from Hepatitis C Virus by circular RNA sponges

Abstract: Circular RNAs (circRNAs) were recently described as a novel class of cellular RNAs. Two circRNAs were reported to function as molecular sponges, sequestering specific microRNAs, thereby de-repressing target mRNAs. Due to their elevated stability in comparison to linear RNA, circRNAs may be an interesting tool in molecular medicine and biology. In this study, we provide a proof-of-principle that circRNAs can be engineered as microRNA sponges. As a model system, we used the Hepatitis C Virus (HCV), which require… Show more

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Cited by 107 publications
(155 citation statements)
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“…Several clinical studies have demonstrated that the inhibitors of miR‐122 play an important role in reducing viral load in HCV patients with chronic infection. Other researchers have designed circRNA sponges to absorb miR‐122 . Such artificial circRNAs possess the capacity to mount inhibition on viral protein synthesis, hence leading to the suppression of HCV replication.…”
Section: Circrnas Block the Hepatitis Virus Infectionmentioning
confidence: 99%
“…Several clinical studies have demonstrated that the inhibitors of miR‐122 play an important role in reducing viral load in HCV patients with chronic infection. Other researchers have designed circRNA sponges to absorb miR‐122 . Such artificial circRNAs possess the capacity to mount inhibition on viral protein synthesis, hence leading to the suppression of HCV replication.…”
Section: Circrnas Block the Hepatitis Virus Infectionmentioning
confidence: 99%
“…Many viruses, including KSHV, encode miRNAs and target human or viral transcripts (12). Recently, miR-122 targeting artificial circRNAs was designed and proven to have antiviral capacity (13). These developments raise the possibility that natural human circular RNAs can potentially act as antiviral molecules if they contain binding sites for…”
mentioning
confidence: 99%
“…8 Generally, 5-FU is commonly used to treat BC. [10][11][12] CircRNAs are proved as potential biomarkers in many diseases including hepatoma carcinoma and other cancers. 9 Circular RNA (CircRNA) is a naturally occurring family of noncoding RNAs, which has been commonly detected in viruses, plant and animals.…”
Section: -Fluorouracil (5-fu) Is Well-known For Its Anti-tumour Effectmentioning
confidence: 99%
“…9 Circular RNA (CircRNA) is a naturally occurring family of noncoding RNAs, which has been commonly detected in viruses, plant and animals. [10][11][12] CircRNAs are proved as potential biomarkers in many diseases including hepatoma carcinoma and other cancers. 13 CDR1as (also known as CiRS-7), one of the thousands of CircRNAs, was recently demonstrated to function as a powerful miR-7 sponge/ inhibitor in developing midbrain of zebrafish, suggesting a novel mechanism for regulating microRNA functions.…”
Section: Introductionmentioning
confidence: 99%