Functional sensitivity of seven automated thyroid stimulating hormone immunoassays

Longitudinal evaluation of thyroid autoimmunity and function in pregnant Korean women

“…Representative total imprecision for these assays in our laboratory is as follows: TSH, 2.39% at 0.108 mIU/mL and 2.23% at 29.94 mIU/mL; FT4, 5.53% at 8.50 and 2.51% at 38.35 pmol/L, respectively; TT4, 4.17% at 58.95 and 3.20% at 208.11 nmol/L, respectively; TT3, 1.52% at 1.58 and 1.88% at 5.05 nmol/L, respectively; TPO-Ab, 7.57% at 0.72 mIU/mL and 2.98% at 84.21 IU/mL; and Tg-Ab 6.81% at 0.78 IU/mL and 1.95% at 156.99 IU/mL. Further performance characteristics of these assays have been previously described [13,14]. Data analysis was performed using AnalyseIt software, version 2.20 (Leeds, UK).…”

Thyroid-stimulating hormone and free thyroxine on the ADVIA Centaur immunoassay system: A multicenter assessment of analytical performance

“…At the laboratory-scale, performance quality should be assessed to ensure agreement with the performance announced by the manufacturer. Indeed, studies have reported discordances between the manufacturers' claims and the laboratory assessment [5,6]. Consequently, when Siemens optimized the TSH3 and FrT4 assays to produce the new and improved TSH3-ultra (TSH3-UL) and FT4 assays, we assessed the key analytical performance characteristics of the new assays on the ADVIA Centaur immunoassay system in a multicenter national evaluation.…”

Thyroid function and thyroid autoimmunity in apparently healthy pregnant and non-pregnant Mexican women

“…Assay testing was performed by chemiluminescent immunoassay on the Abbott ARCHITECT analyzer (Abbott Laboratories, Abbott Park, IL, USA) according to manufacturer's instructions. The principles of this instrument system and performance characteristics for these assays have been previously described [12][13][14][15]. Manufacturer's cut-off values for Anti-TPO ( < 5.6 IU/mL) and Anti-Tg ( < 4.11 IU/ mL) were used.…”