Functional scaffolds of bicontinuous, thermoresponsive L<sub>3</sub>-phase silica/hydroxyapatite nanocomposites

Chang, Jinhwa; Park, Moo Eon; Shin, Yongsoon; Kim, Kyung Ja; Lee, Sang Cheon; Oh, Kwang‐Seok

doi:10.1039/b609409k

Cited by 12 publications

(6 citation statements)

References 19 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the pure hydroxyapatite material is brittle, its mechanical properties are poor and cannot be used for load-bearing bone repair. Thus, HA/biopolymer nanocomposites have been prepared to obtain bone repair materials with wonderful mechanical and bioproperties [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Mechanical and thermal properties of polypeptide modified hydroxyapatite/poly(L-lactide) nanocomposites

et al. 2011

View full text Add to dashboard Cite

A new type of polypeptide (poly(-benzyl-L-glutamate) (PBLG)) modified hydroxyapatite (HA)/poly(L-lactide) (PLLA) nanocomposites (PBLG-g-HA/PLLA) were prepared by the solvent-mixing method, and their mechanical and thermal properties were investigated. The tensile test showed that the mechanical properties of PBLG-g-HA/PLLA nanocomposites were better than that of PLLA, even a 0.3 wt% content of PBLG-g-HA in the nanocomposites could make the tensile strength 12% higher than that of the neat PLLA sample, and the tensile modulus was about 17% higher than that of the PLLA sample. The thermal gravimetric analysis (TGA) showed that the PBLG-g-HA/PLLA composites have better thermal stability than the PLLA sample. The differential scanning calorimetry (DSC) was used to characterize the effect of PBLG-g-HA on the crystallization of PLLA. The isothermal crystallization behavior showed that the half crystallization time (t 1/2 ) of PBLG-g-HA/PLLA was much shorter than that of the PLLA sample. When the PBLG-g-HA content was 10%, t 1/2 was only 18.7 min, while t 1/2 of the PLLA sample was 61.4 min. The results showed that the PBLG-g-HA worked as a nucleating agent and enhanced the crystallization speed of PLLA.hydroxyapatite, poly(L-lactide), nanocomposite, surface modification

show abstract

Section: Introductionmentioning

confidence: 99%

Mechanical and thermal properties of polypeptide modified hydroxyapatite/poly(L-lactide) nanocomposites

et al. 2011

View full text Add to dashboard Cite

show abstract

“…[18][19][20] In addition, the use of nano-HAp as scaffolds for loading or compositing of inorganic functional materials has been shown to be an effective way for endowing biocompatibility to these materials, such as Fe 3 O 4 magnetic nanoparticles, 21,22 carbon nanotube, 23 zirconia 24 and silica. 25 For the loading of QDs, Guo et al conjugated CdSe@ZnS QDs with nano-HAp to improve the biocompatibility of QDs for in vivo imaging; 26 Chang et al labeled nano-HAp with CdSe@ZnS QDs via compositing to investigate the interaction between nano-HAp and MC3T3-E1 osteoblast cells. 27 Clearly, the biocompatibility of CdSe@ZnS QDs was largely increased after merging with nano-HAp.…”

Section: Introductionmentioning

confidence: 99%

Low-toxic Mn-doped ZnSe@ZnS quantum dots conjugated with nano-hydroxyapatite for cell imaging

Zhou

Wang

et al. 2014

Nanoscale

View full text Add to dashboard Cite

Fluorescent bio-imaging has received significant attention in a myriad of research disciplines, and QDs are playing an increasingly important role in these areas. Doped QDs, an important alternative to conventional heavy metal-containing QDs are employed for biomedical applications. However, since QDs are exogenous substances to the biological environment, the biocompatibility of QDs is expected to be challenging in some cases. Herein, nano fluorine-doped hydroxyapatite (FAp, a well-known biocompatible material) was introduced to endow biocompatibility to Cd-free Mn-doped ZnSe@ZnS QDs. Thus, a nano-FAp-QD conjugate was developed and the biocompatibility, as well as potential cell imaging application, was investigated. To construct the proposed conjugate, Cd-free highly luminescent Mn-doped ZnSe@ZnS QDs and monodispersed nano-FAp were first prepared in high-temperature organic media. For facilitating the conjugation, hydrophobic nano-FAp was made water soluble via o-phosphoethanolamine (PEA) coating, which further provides conjugating sites for QDs to anchor. Cytotoxicity studies indicated the developed conjugate indeed possesses good compatibility and low toxicity to cells. The nano-FAp-QDs conjugate was successfully employed for cancer cell staining for at least 24 h, demonstrating the potential usefulness of this material in future biomedical research.

show abstract

“…17,18 The association of hydroxyapatite with metal oxides for biomedical purposes has already been widely described in the literature. 19 In particular, silica-, [20][21][22] alumina-, [23][24][25] titania- [26][27][28] and zirconia-based [29][30][31] composites have been studied for the design of bioceramics mainly due to their enhanced chemical and mechanical stability compared to the pure apatite phase. In contrast, very few studies considered the application of such materials as sorbents.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Synthesis of Mesoporous Zirconia-Hydroxyapatite Nanocomposites and Their Dual Surface Affinity for Cr³⁺/Cr₂O₇^2– Ions

et al. 2011

View full text Add to dashboard Cite

Zirconia-hydroxyapatite nanocomposites were prepared by sol-gel deposition of zirconium oxide from a zirconium alkoxide in the presence of apatite colloidal suspension under ultrasonication. The material porosity evolves from mainly microporous zirconia to mesoporous hydroxyapatite, with decreasing surface area and increasing pore volume. XRD studies indicate that the apatite phase is well-preserved within the composite materials. The homogeneous dispersion of apatite colloids within the zirconia network was supported by TEM observations and nitrogen sorption measurements. (31)P solid-state NMR studies suggest that partial dissolution of apatite may have occurred during the preparation, leading to the adsorption of phosphate species on zirconia particles. This is confirmed by XRD studies of nanocomposites after thermal treatment that demonstrate the preferred formation of tetragonal over monoclinic ZrO(2) in the presence of hydroxyapatite. In order to investigate the surface properties of these novel materials, the adsorption of Pb(2+), Cr(3+), and Cr(2)O(7)(2-) was evaluated. Metal cations were preferentially adsorbed on apatite-rich composites, whereas Cr(2)O(7)(2-) shows a good affinity for the zirconia-rich phases. Zirconia-apatite materials showed the most promising performance in terms of recyclability. These nanocomposites that combine microporosity, mesoporosity and dual sorption properties for these species appear as interesting materials for metal ion remediation and may also find applications as biomaterials.

show abstract

Functional scaffolds of bicontinuous, thermoresponsive L₃-phase silica/hydroxyapatite nanocomposites

Cited by 12 publications

References 19 publications

Mechanical and thermal properties of polypeptide modified hydroxyapatite/poly(L-lactide) nanocomposites

Mechanical and thermal properties of polypeptide modified hydroxyapatite/poly(L-lactide) nanocomposites

Low-toxic Mn-doped ZnSe@ZnS quantum dots conjugated with nano-hydroxyapatite for cell imaging

Ultrasound-Assisted Synthesis of Mesoporous Zirconia-Hydroxyapatite Nanocomposites and Their Dual Surface Affinity for Cr³⁺/Cr₂O₇^2– Ions

Contact Info

Product

Resources

About

Functional scaffolds of bicontinuous, thermoresponsive L3-phase silica/hydroxyapatite nanocomposites

Cited by 12 publications

References 19 publications

Mechanical and thermal properties of polypeptide modified hydroxyapatite/poly(L-lactide) nanocomposites

Mechanical and thermal properties of polypeptide modified hydroxyapatite/poly(L-lactide) nanocomposites

Low-toxic Mn-doped ZnSe@ZnS quantum dots conjugated with nano-hydroxyapatite for cell imaging

Ultrasound-Assisted Synthesis of Mesoporous Zirconia-Hydroxyapatite Nanocomposites and Their Dual Surface Affinity for Cr3+/Cr2O72– Ions

Contact Info

Product

Resources

About

Functional scaffolds of bicontinuous, thermoresponsive L₃-phase silica/hydroxyapatite nanocomposites

Ultrasound-Assisted Synthesis of Mesoporous Zirconia-Hydroxyapatite Nanocomposites and Their Dual Surface Affinity for Cr³⁺/Cr₂O₇^2– Ions