Functional roles of the monoaminergic and aminoacidergic mechanisms of the dorsal pallidum in anxiety of different aversive origins

Talalaenko, A. N.; Krivobok, G. K.; Bulgakova, N. P.; Pankrat'ev, D. V.

doi:10.1007/s11055-008-0016-0

Cited by 9 publications

(9 citation statements)

References 5 publications

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“…One possibility therefore is that activation of this area reflects disruption of the motor system as a component of the emotional response in SAD. However, the globus pallidus has also been implicated in affect regulation (Murphy et al, 2003), and in both the processing of information from complex stimuli and in aversive responses to fear and anxiety (Talalaenko et al, 2008). Thus, activation in this region may reflect increased statistical power of this meta-analysis relative to those previously conducted.…”

Section: Discussionmentioning

confidence: 99%

Functional magnetic resonance imaging during emotion recognition in social anxiety disorder: an activation likelihood meta-analysis

Hattingh¹,

Ipser²,

Tromp³

et al. 2013

Front. Hum. Neurosci.

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Background: Social anxiety disorder (SAD) is characterized by abnormal fear and anxiety in social situations. Functional magnetic resonance imaging (fMRI) is a brain imaging technique that can be used to demonstrate neural activation to emotionally salient stimuli. However, no attempt has yet been made to statistically collate fMRI studies of brain activation, using the activation likelihood-estimate (ALE) technique, in response to emotion recognition tasks in individuals with SAD. Methods: A systematic search of fMRI studies of neural responses to socially emotive cues in SAD was undertaken. ALE meta-analysis, a voxel-based meta-analytic technique, was used to estimate the most significant activations during emotional recognition. Results: Seven studies were eligible for inclusion in the meta-analysis, constituting a total of 91 subjects with SAD, and 93 healthy controls. The most significant areas of activation during emotional vs. neutral stimuli in individuals with SAD compared to controls were: bilateral amygdala, left medial temporal lobe encompassing the entorhinal cortex, left medial aspect of the inferior temporal lobe encompassing perirhinal cortex and parahippocampus, right anterior cingulate, right globus pallidus, and distal tip of right postcentral gyrus. Conclusion: The results are consistent with neuroanatomic models of the role of the amygdala in fear conditioning, and the importance of the limbic circuitry in mediating anxiety symptoms.

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Section: Discussionmentioning

confidence: 99%

Functional magnetic resonance imaging during emotion recognition in social anxiety disorder: an activation likelihood meta-analysis

Hattingh¹,

Ipser²,

Tromp³

et al. 2013

Front. Hum. Neurosci.

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“…Specifically, anxiety mediating CNS structures such as the posterior hypothalamic area (hypothalamic hub regulating anxiety [17]) as well as the globus pallidus [27] were both functionally connected to the anterior cingulate only at Day 2. The anteroventral thalamus has reciprocal connection with the anterior cingulate cortex and is implicated in mediating learning, memory and attention [28], [29].…”

Section: Discussionmentioning

confidence: 99%

Default-Mode-Like Network Activation in Awake Rodents

et al. 2011

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During wakefulness and in absence of performing tasks or sensory processing, the default-mode network (DMN), an intrinsic central nervous system (CNS) network, is in an active state. Non-human primate and human CNS imaging studies have identified the DMN in these two species. Clinical imaging studies have shown that the pattern of activity within the DMN is often modulated in various disease states (e.g., Alzheimer's, schizophrenia or chronic pain). However, whether the DMN exists in awake rodents has not been characterized. The current data provides evidence that awake rodents also possess ‘DMN-like’ functional connectivity, but only subsequent to habituation to what is initially a novel magnetic resonance imaging (MRI) environment as well as physical restraint. Specifically, the habituation process spanned across four separate scanning sessions (Day 2, 4, 6 and 8). At Day 8, significant (p<0.05) functional connectivity was observed amongst structures such as the anterior cingulate (seed region), retrosplenial, parietal, and hippocampal cortices. Prior to habituation (Day 2), functional connectivity was only detected (p<0.05) amongst CNS structures known to mediate anxiety (i.e., anterior cingulate (seed region), posterior hypothalamic area, amygdala and parabracial nucleus). In relating functional connectivity between cingulate-default-mode and cingulate-anxiety structures across Days 2-8, a significant inverse relationship (r = −0.65, p = 0.0004) was observed between these two functional interactions such that increased cingulate-DMN connectivity corresponded to decreased cingulate anxiety network connectivity. This investigation demonstrates that the cingulate is an important component of both the rodent DMN-like and anxiety networks.

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“…GP is usually associated with motor behaviour, and it has also been shown to play an important role in performing aversive behaviour based on emotions, including fear and anxiety . The rapid accumulation of manganese in GP (Fig.…”

Section: Discussionmentioning

confidence: 99%

Regional specificity of manganese accumulation and clearance in the mouse brain: implications for manganese‐enhanced MRI

et al. 2012

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Manganese-enhanced MRI has recently become a valuable tool for the assessment of in vivo functional cerebral activity in animal models. As a result of the toxicity of manganese at higher dosages, fractionated application schemes have been proposed to reduce the toxic side effects by using lower concentrations per injection. Here, we present data on regional-specific manganese accumulation during a fractionated application scheme over 8 days of 30 mg/kg MnCl2 , as well as on the clearance of manganese chloride over the course of several weeks after the termination of the whole application protocol supplying an accumulative dose of 240 mg/kg MnCl2 . Our data show most rapid accumulation in the superior and inferior colliculi, amygdala, bed nucleus of the stria terminalis, cornu ammonis of the hippocampus and globus pallidus. The data suggest that no ceiling effects occur in any region using the proposed application protocol. Therefore, a comparison of basal neuronal activity differences in different animal groups based on locally specific manganese accumulation is possible using fractionated application. Half-life times of manganese clearance varied between 5 and 7 days, and were longest in the periaqueductal gray, amygdala and entorhinal cortex. As the hippocampal formation shows one of the highest T1 -weighted signal intensities after manganese application, and manganese-induced memory impairment has been suggested, we assessed hippocampus-dependent learning as well as possible manganese-induced atrophy of the hippocampal volume. No interference of manganese application on learning was detected after 4 days of Mn(2+) application or 2 weeks after the application protocol. In addition, no volumetric changes induced by manganese application were found for the hippocampus at any of the measured time points. For longitudinal measurements (i.e. repeated manganese applications), a minimum of at least 8 weeks should be considered using the proposed protocol to allow for sufficient clearance of the paramagnetic ion from cerebral tissue.

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Functional roles of the monoaminergic and aminoacidergic mechanisms of the dorsal pallidum in anxiety of different aversive origins

Cited by 9 publications

References 5 publications

Functional magnetic resonance imaging during emotion recognition in social anxiety disorder: an activation likelihood meta-analysis

Functional magnetic resonance imaging during emotion recognition in social anxiety disorder: an activation likelihood meta-analysis

Default-Mode-Like Network Activation in Awake Rodents

Regional specificity of manganese accumulation and clearance in the mouse brain: implications for manganese‐enhanced MRI

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