Functional Role of MicroRNAs in Thymocyte Development

Hu, Lin; Mao, Ling; Liu, Shiming; Zhao, Juanjuan; Chen, Chao; Guo, Ming; He, Zhixu; Yang, Jie; Xu, Wei; Xu, Lin

doi:10.1159/000496093

Cited by 7 publications

(18 citation statements)

References 56 publications

(52 reference statements)

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“…T-lymphocytes, or T-cells, arise from the early T-lineage precursor of the bone marrow that is guided in the thymus to mature and then migrate into peripheral immune tissues to carry out biological functions [ 106 ]. In the thymus, the central immune organ, the development of T-cells is divided into several stages according to the expression of CD4 and CD8 coreceptors [ 108 ].…”

Section: Mirnas and T Cellmentioning

confidence: 99%

MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia

Gaizo

Sergio

Lazzari

et al. 2022

IJMS

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Acute lymphoblastic leukaemia (ALL) is an aggressive haematological tumour driven by the malignant transformation and expansion of B-cell (B-ALL) or T-cell (T-ALL) progenitors. The evolution of T-ALL pathogenesis encompasses different master developmental pathways, including the main role played by Notch in cell fate choices during tissue differentiation. Recently, a growing body of evidence has highlighted epigenetic changes, particularly the altered expression of microRNAs (miRNAs), as a critical molecular mechanism to sustain T-ALL. The immune response is emerging as key factor in the complex multistep process of cancer but the role of miRNAs in anti-leukaemia response remains elusive. In this review we analyse the available literature on miRNAs as tuners of the immune response in T-ALL, focusing on their role in Natural Killer, T, T-regulatory and Myeloid-derived suppressor cells. A better understanding of this molecular crosstalk may provide the basis for the development of potential immunotherapeutic strategies in the leukemia field.

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Section: Mirnas and T Cellmentioning

confidence: 99%

MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia

Gaizo

Sergio

Lazzari

et al. 2022

IJMS

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“…Nevertheless, these results demonstrate that miRNAs can modulate T-cell development. Different studies have shown that individual miRNAs are dynamically regulated during T-cell development and maturation as detailed below (25)(26)(27).…”

Section: Mirnas and Thymocyte Developmentmentioning

confidence: 99%

Role of miRNAs in Normal and Myasthenia Gravis Thymus

et al. 2020

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The thymus, a primary lymphoid organ, provides a complex environment essential for the generation of the T-cell repertoire. Thymic alterations occur during life either in the context of thymic involution upon aging or the pathophysiological context of Myasthenia Gravis (MG). These changes involve complicated regulatory networks, in which microRNAs (miRNAs) are key players. Here, we analyzed the role of miRNAs in thymocyte maturation and differentiation sustained by thymic epithelial cells. We compared data from the literature regarding the role of mouse thymic miRNAs and original data obtained from a human thymic miRnome study. We identified a set of highly expressed miRNAs defined as ThymiRs and investigated miRNA expression in infants as compared to adults to determine those associated with human thymic involution. Thymic changes are also frequently observed in MG, an autoimmune disease which results in the production of anti-acetylcholine receptor (AChR) antibodies that lead to muscle weaknesses. Alterations such as thymoma in late-onset MG patients and hyperplasia with ectopic germinal centers (GCs) in early-onset (EOMG) patients are found. Thymic miRNA expression has been studied in AChR-MG patients both in thymoma-associated MG (TAMG) and EOMG, and their function through their mRNA targets investigated. Most of the dysregulated thymic miRNAs in EOMG are associated with GC development, such as miR-7, miR-24, miR-139, miR-143, miR-145, miR-146, miR-150, miR-452, miR-548 or thymic inflammation, such as miR-125b, miR-146, or miR-29. Understanding these pathways may provide therapeutic targets or biomarkers of disease manifestations.

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“…The evolution of T cells in thymus is controlled by a complex protein signaling network. Additionally, miRNAs have a significant role in the orchestration of this complex protein signaling network (Hu et al, 2019; Figure 1).…”

Section: Mirnas Involved In T‐cell Development and Selectionmentioning

confidence: 99%

“…miR‐146a establishes the balance between apoptosis and the survival of thymocytes in the DP phase via targeting GTPase, IMAP family member 3 (Gimap3), GTPase, IMAP family member 4 (Gimap4) gene. Subsequently, miR‐146a orchestrates positive selection (Hu et al, 2019; Z. Li et al, 2018). The mouse models have shown that overexpression of miR‐146a leads to the inhibition of the positive selection in thymocytes.…”

Section: Mirnas Involved In T‐cell Development and Selectionmentioning

confidence: 99%

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microRNAs involved in T‐cell development, selection, activation, and hemostasis

Tapeh

Mosayyebi

Samei

et al. 2020

Journal Cellular Physiology

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MicroRNAs (miRNAs) characterized by small, noncoding RNAs have a fundamental role in the regulation of gene expression at the post‐transcriptional level. Additionally, miRNAs have recently been identified as potential regulators of various genes involved in the pathogenesis of the autoimmune and inflammatory disease. So far, the interaction between miRNAs and T lymphocytes in the immune response as a new and significant topic has not been emphasized substantially. The role of miRNAs in different biological processes including apoptosis, immune checkpoints and the activation of immune cells is still unclear. Aberrant miRNA expression profile affects various aspects of T‐cell function. Accordingly, in this literature review, we summarized the role of significant miRNAs in T‐cell development processes. Consequently, we demonstrated precise mechanisms that candidate miRNAs interfere in Immune response mediated by different types of T cells. We believe that a good understanding of the interaction between miRNAs and immune response contributes to the new therapeutic strategies in relation to disease with an immunological origin.

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Functional Role of MicroRNAs in Thymocyte Development

Cited by 7 publications

References 56 publications

MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia

MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia

Role of miRNAs in Normal and Myasthenia Gravis Thymus

microRNAs involved in T‐cell development, selection, activation, and hemostasis

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