Functional role of lipid rafts in CD20 activity?

Janas, Eva; Priest, Richard; Malhotra, Rajneesh

doi:10.1042/bss0720165

Cited by 11 publications

(7 citation statements)

References 59 publications

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“…All tissue cells appear to have rafts involved in transmembrane signalling, and there are mechanisms to produce very large rafts or ‘super-rafts’ due to the presence of galectin, a lectin that binds galactose in intestinal brush border cells (Braccia et al 2003). Ion channels often function in rafts (Janas et al 2005) and the carbohydrate hyaluronan (containing hyaluronic acid) binds to its receptor CD44 and the resulting signalling requires rafts (Singleton and Bourguinon, 2004).…”

Section: The Organization Of Proteins and Lipids In The Bilayersmentioning

confidence: 99%

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The schistosome in the mammalian host: understanding the mechanisms of adaptation

2007

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In this review, we envisage the host environment, not as a hostile one, since the schistosome thrives there, but as one in which the relationship between the two organisms consists of constant communication, through signalling mechanisms involving sense organs, surface glycocalyx, surface membrane and internal organs of the parasite, with host fluids and cells. The surface and secretions of the schistosome egg have very different properties from those of other parasite stages, but adapted for the dispersal of the eggs and for the preservation of host liver function. We draw from studies of mammalian cells and other organisms to indicate how further work might be carried out on the signalling function of the surface glycocalyx, the raft structure of the surface and existence of pores in the surface membrane, the repair of the surface membrane, the role of the membrane structure in ion channel function (including recent work on the actin cytoskeleton and calcium channels) and the possible role of P-glycoproteins in the adaptation of the parasite to its environment. We are speculative in some areas, such as the suggestions that variability in surface properties of schistosomes may relate to the existence of membrane rafts and that parasite communities may exhibit quorum sensing. This speculative approach is adopted with the hope that future work on the whole organisms and their interactions will be encouraged.

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Section: The Organization Of Proteins and Lipids In The Bilayersmentioning

confidence: 99%

“…Ion channels often function in rafts (Janas et al 2005) and the carbohydrate hyaluronan (containing hyaluronic acid) binds to its receptor CD44 and the resulting signalling requires rafts (Singleton and Bourguinon, 2004).…”

Section: The Organization Of Proteins and Lipids In The Bilayersmentioning

confidence: 99%

The schistosome in the mammalian host: understanding the mechanisms of adaptation

2007

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“…The specimens of soft tissues of the oral cavity (alveolar mucosa attached gingival and buccal mucosa from area to lateral side of incisors margins) were stained with hematoxylin and eosin (H&E), according to van Gieson after the routine proceeding. Immunohistochemical examination (IHC) was performed by indirect immunoperoxidase reaction [24] with monoclonal antibodies (mAb) to VEGF, CD23 (detected on mature B cells, activated macrophages, eosinophils, has affinity with IgE [25]), CD20 (receptor located on the surface of all B-lymphocytes [26]). All used mAbs are manufactured by Thermo scientific.…”

Section: Methodsmentioning

confidence: 99%

Peculiarities of vascular endothelial growth factor of oral cavity in atopic condition VEGF of oral cavity in atopic condition

Nazaryan

Kryvenko

Gargin

2021

Interventional Medicine and Applied Science

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Background and aimsVascular endothelial growth factor (VEGF) is regarded as a potent stimulating factor for angiogenesis and vascular permeability and probably is connected with an inflammatory reaction. Our study aimed to determine the effect of VEGF in the inflammatory process in the oral mucosa of experimental animals in the modulation of atopic disease.Materials and methodsAtopic condition was simulated by the ovalbumin model. Obtained specimens of oral mucosa were examined histologically; immunohistochemistry was performed with detection VEGF, CD23, CD20.ResultsMost pronounced changes with twice increased expression activity of VEGF has been detected in the affected areas of the lamina propria and were associated with perivascular inflammatory microinfiltration, but unexpected expression in the epithelial layer has been revealed surround of intraepithelial inflammatory cells mainly. Pronounced correlations have been detected as VEGF and CD23 (r = 0.91), VEGF and CD20 (r = 0.87), CD23 and CD20 (r = 0.89).Discussiondescribed the changes in the tissues of the oral mucosa could be served as a basis for the development of preventive measures in patients with atopic diseases.discussionConclusionsActivation of VEGF is connected with accumulation of inflammatory infiltrate represented by B-lymphocytes, activated macrophages, eosinophils with a correlation in atopic process.

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“…Rituxan) induces a rapid redistribution of CD20 into specialized plasma membrane microdomains, known as lipid rafts. It appears that recruitment of CD20 into lipid rafts and its homo-oligomerization is crucial for CD20 activity and regulation [109]. The absence of internalization or shedding from the plasma membrane following MoAb treatment, allows anti-CD20 to persist on the cell surface for extended periods leading to immunological attack from complement and FcR-expressing innate effectors [110].…”

Section: Rituximab Treatmentmentioning

confidence: 99%

A Combined Approach with Rituximab Plus Anti-TRAIL-R Agonistic Antibodies for the Treatment of Haematological Malignancies

Sancilio

Grill²,

Pietro

2008

CPD

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Molecular targeted therapies have changed the landscape of cancer research. Agonistic monoclonal antibodies (MoAbs) targeting TRAIL-death receptors (TRAIL-Rs) have been developed and currently used in clinical trials. Binding of such antibodies to TRAIL-R1 and TRAIL-R2 results in death inducing signalling complex (DISC) formation and induction of apoptosis, which represents a natural mechanism of cell growth control and an ideal target for drug development. These novel fully humanized compounds have been associated with conventional chemotherapy in the treatment of advanced solid malignancies, including different types of lymphoma. Here we outline the rationale and potential of a new molecular-based strategy combining agonistic anti-TRAIL-death receptor monoclonal antibodies plus the pioneer of the new biological frontiers of cancer therapy: rituximab.

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Functional role of lipid rafts in CD20 activity?

Cited by 11 publications

References 59 publications

The schistosome in the mammalian host: understanding the mechanisms of adaptation

The schistosome in the mammalian host: understanding the mechanisms of adaptation

Peculiarities of vascular endothelial growth factor of oral cavity in atopic condition VEGF of oral cavity in atopic condition

A Combined Approach with Rituximab Plus Anti-TRAIL-R Agonistic Antibodies for the Treatment of Haematological Malignancies

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