Functional role of left PMd and left M1 during preparation and execution of left hand movements in older adults

Fujiyama, Hakuei; Hinder, Mark R.; Summers, Jeffery J.

doi:10.1152/jn.00075.2013

Cited by 20 publications

(10 citation statements)

References 47 publications

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“…Only in older adults, the wPLI value between PMd L –M1 L correlated positively with the wPLI value of PMd R –M1 L connection. This is in line with (Fujiyama, Hinder, & Summers, ) and suggests left hemisphere (PMd L ) to be involved in inhibitory processing related to impulse control. Moreover, the significant correlation between PMd L –M1 L and PMd R –M1 L indicates the effect of both ipsilateral and contralateral PMd on M1 L to control right hand movement only in older adults, which is in line with previous studies suggesting the involvement of both ipsilateral and contralateral PMd in the output from M1 in older adults (Fujiyama et al, ; Zimerman, Heise, Gerloff, Cohen, & Hummel, ).…”

Section: Discussionsupporting

confidence: 90%

A combined diffusion‐weighted and electroencephalography study on age‐related differences in connectivity in the motor network during bimanual performance

Babaeeghazvini

Rueda‐Delgado

Adab

et al. 2018

Human Brain Mapping

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We studied the relationship between age‐related differences in inter‐ and intra‐hemispheric structural and functional connectivity in the bilateral motor network. Our focus was on the correlation between connectivity and declined motor performance in older adults. Structural and functional connectivity were estimated using diffusion weighted imaging and resting‐state electro‐encephalography, respectively. A total of 48 young and older healthy participants were measured. In addition, motor performances were assessed using bimanual coordination tasks. To pre‐select regions‐of‐interest (ROIs), a neural model was adopted that accounts for intra‐hemispheric functional connectivity between dorsal premotor area (PMd) and primary motor cortex (M1) and inter‐hemispheric connections between left and right M1 (M1L and M1R). Functional connectivity was determined via the weighted phase‐lag index (wPLI) in the source‐reconstructed beta activity during rest. We quantified structural connectivity using kurtosis anisotropy (KA) values of tracts derived from diffusion tensor‐based fiber tractography between the aforementioned areas. In the group of older adults, wPLI values between M1L–M1R were negatively associated with the quality of bimanual motor performance. The additional association between wPLI values of PMdL––M1L and PMdR–M1L supports that functional connectivity with the left hemisphere mediated (bimanual) motor control in older adults. The correlational analysis between the selected structural and functional connections revealed a strong association between wPLI values in the left intra‐hemispheric PMdL–M1L pathway and KA values in M1L–M1R and PMdR–M1L pathways in the group of older adults. This suggests that weaker structural connections in older adults correlate with stronger functional connectivity and, hence, poorer motor performance.

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Section: Discussionsupporting

confidence: 90%

A combined diffusion‐weighted and electroencephalography study on age‐related differences in connectivity in the motor network during bimanual performance

Babaeeghazvini

Rueda‐Delgado

Adab

et al. 2018

Human Brain Mapping

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show abstract

“…We assumed that the capability to inhibit the ipsilateral M1 allows the brain to avoid potential disturbance from the M1, for elaborate control by the contralateral one [6]. This view seems to be compatible with our findings that ipsilateral M1 activity was correlated with deteriorated dexterity (Figure 3) and that the reduction of ipsilateral M1 activity was associated with dexterity improvement (Figure 4) in older adults, who may partially utilize the ipsilateral M1 when performing a motor task [43].…”

supporting

confidence: 87%

Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition

Naito

Morita

Hirose

et al. 2021

Preprint

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Improving deteriorated sensorimotor functions in older individuals is a social necessity in a super aging society. Previous studies suggested that the declined interhemispheric sensorimotor inhibition observed in older adults is associated with their deteriorated hand/finger dexterity. Here, we examined whether bimanual digit exercises, which can train the interhemispheric inhibitory system, improve deteriorated hand/finger dexterity in older adults. Forty-eight healthy, right-handed, older adults (65-78 years old) were divided into two groups, i.e., the bimanual (BM) digit training and right-hand (RH) training groups, and intensive daily training was performed for 2 months. Before and after the training, we evaluated individual right hand/finger dexterity using a peg task, and the individual state of interhemispheric sensorimotor inhibition by analyzing ipsilateral sensorimotor deactivation via functional magnetic resonance imaging when participants experienced a kinesthetic illusory movement of the right-hand without performing any motor tasks. Before training, the degree of reduction/loss of ipsilateral motor-cortical deactivation was associated with dexterity deterioration. After training, the dexterity improved only in the BM group, and the dexterity improvement was correlated with reduction in ipsilateral motor-cortical activity. The capability of the brain to inhibit ipsilateral motor-cortical activity during a simple right-hand sensory-motor task is tightly related to right-hand dexterity in older adults.

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“…4 ) and that the reduction of ipsilateral M1 activity was associated with dexterity improvement (Fig. 5 ) in older adults, who may partially utilize the ipsilateral M1 when performing a motor task 43 .…”

Section: Discussionmentioning

confidence: 89%

Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition

Naito

Morita

Hirose

et al. 2021

Sci Rep

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Improving deteriorated sensorimotor functions in older individuals is a social necessity in a super-aging society. Previous studies suggested that the declined interhemispheric sensorimotor inhibition observed in older adults is associated with their deteriorated hand/finger dexterity. Here, we examined whether bimanual digit exercises, which can train the interhemispheric inhibitory system, improve deteriorated hand/finger dexterity in older adults. Forty-eight healthy, right-handed, older adults (65–78 years old) were divided into two groups, i.e., the bimanual (BM) digit training and right-hand (RH) training groups, and intensive daily training was performed for 2 months. Before and after the training, we evaluated individual right hand/finger dexterity using a peg task, and the individual state of interhemispheric sensorimotor inhibition by analyzing ipsilateral sensorimotor deactivation via functional magnetic resonance imaging when participants experienced a kinesthetic illusory movement of the right-hand without performing any motor tasks. Before training, the degree of reduction/loss of ipsilateral motor-cortical deactivation was associated with dexterity deterioration. After training, the dexterity improved only in the BM group, and the dexterity improvement was correlated with reduction in ipsilateral motor-cortical activity. The capability of the brain to inhibit ipsilateral motor-cortical activity during a simple right-hand sensory-motor task is tightly related to right-hand dexterity in older adults.

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Functional role of left PMd and left M1 during preparation and execution of left hand movements in older adults

Abstract: Fujiyama H, Hinder MR, Summers JJ. Functional role of left PMd and left M1 during preparation and execution of left hand movements in older adults.

Cited by 20 publications

References 47 publications

A combined diffusion‐weighted and electroencephalography study on age‐related differences in connectivity in the motor network during bimanual performance

A combined diffusion‐weighted and electroencephalography study on age‐related differences in connectivity in the motor network during bimanual performance

Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition

Bimanual digit training improves right-hand dexterity in older adults by reactivating declined ipsilateral motor-cortical inhibition

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