Functional resting-state connectivity of the human motor network: Differences between right- and left-handers

Pool, Eva-Maria; Rehme, Anne Kathrin; Eickhoff, Simon B.; Fink, Gereon R.; Grefkes, Christian

doi:10.1016/j.neuroimage.2015.01.034

Cited by 73 publications

(43 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In theory, one might explain this discrepancy of results by arguing that handedness as a sensorimotor phenomenon, instead of language lateralization, determines the mean AFC matrix, and thus AFC-scores. We believe this to be highly unlikely, however, considering that all correlations between LTL-score, handedness, and AFC-score were significantly positive, and that asymmetries were not overrepresented in connections with motor areas as would be predicted based on the fact that hand preference can be decoded from RS correlations between the different motor areas (Pool et al 2015). We have as yet no explanation for the apparent contradiction in results.…”

Section: Discussionmentioning

confidence: 74%

Long-term proper name anomia after removal of the uncinate fasciculus

et al. 2014

View full text Add to dashboard Cite

The functional organization of left and right hemispheres is different, and hemispheric asymmetries are thought to underlie variations in brain function across individuals. In this study, we assess how differences between hemispheres are reflected in Asymmetric Functional Connectivity (AFC), which provides a full description of how the brain's connectivity structure during resting state differs from that of the same brain mirrored over the longitudinal fissure. In addition, we assess how AFC varies across subjects. Data were provided by the Human Connectome Project, including 423 resting state and combined language task fMRI data sets, and the pattern of AFC was established for all subjects. While we could quantify the symmetry of brain connectivity at 95%, significant asymmetries were observed, consisting foremost of: (1) higher correlations between language areas in the left hemisphere than between their right hemisphere homologues. (2) Higher correlations between language homologue areas in the right hemisphere and left default mode network, than between language areas in the left hemisphere and the default mode network in the right hemisphere. The extent to which subjects exhibited this pattern correlated with language lateralization and handedness. Further exploration in intersubject variation in AFC revealed several additional patterns, one involving entire hemispheres, and another correlations with limbic areas. These results show that language is an important, but not only determinant of AFC. The additional patterns of AFC require further research to be linked to specific asymmetric neuronal states or events.

show abstract

Section: Discussionmentioning

confidence: 74%

Long-term proper name anomia after removal of the uncinate fasciculus

et al. 2014

View full text Add to dashboard Cite

show abstract

“…A reflection of how strongly a person prefers one hand, degree of hand preference is a behavioural reflection of cerebral lateralization for handedness. This has been reported in several studies assessing both structural and functional cortical organization [30, 31, 32]. For example, using resting-state fMRI, Pool et al [32] identified stronger interhemispheric functional connectivity in right handers.…”

Section: Introductionmentioning

confidence: 56%

“…This has been reported in several studies assessing both structural and functional cortical organization [30, 31, 32]. For example, using resting-state fMRI, Pool et al [32] identified stronger interhemispheric functional connectivity in right handers. As such, the authors suggested functional connectivity between left primary motor cortex and right dorsolateral premotor cortex may be used as an indicator of handedness [32].…”

Section: Introductionmentioning

confidence: 56%

Using Bishop’s Card Reaching Task to Assess Hand Preference in 8- to 10-Year-Old Czech Children

2016

View full text Add to dashboard Cite

Hand preference is one of the most apparent functional asymmetry in humans. Under contralateral control, performance is more proficient with the preferred hand; however, the difference between the two hands is greater in right handers, considering left handers generally display less cerebral lateralization. One method of evaluating hand preference is Bishop’s card reaching task; however, information regarding validity and sensitivity with children in limited. This study assessed the relationship between Bishop’s card reaching task and five hand preference tasks in 8- to 10-year-old typically-developing children from the Czech Republic (N = 376). Structural equation modelling identified a one factor model as the most suitable, including Bishop’s card reaching task and three hand preference tasks (ringing, throwing, and rolling with dice). The factor validity (.89) and sensitivity of Bishop’s card reaching task (90% to 97%) provided a very good identification of hand preference. These results support the suitability of Bishop’s card reaching task as a separate test for determining hand preference in children. Accordingly, we suggest that the assessment of handedness, particularly in neurodevelopmental disorders where the proportion of right-handers and left-handers is disrupted (e.g., children with DCD or ADHD), should make use of Bishop’s card reaching task alongside other unimanual tasks.

show abstract

“…Typically, right-handed individuals show stronger resting state functional connectivity in the left hemisphere, compared to that of left-handed individuals (Saenger, Barrios, Martínez-Gudiño, & Alcauter, 2012). Greater left-sided functional connectivity has been shown to be associated with better cognitive (e.g., reading, comprehension) (Koyama et al, 2011) and motor performance (e.g., hand movements) (Barber et al, 2011; Pool, Rehme, Eickhoff, Fink, & Grefkes, 2015; Pool, Rehme, Fink, Eickhoff, & Grefkes, 2014). O'Muircheartaigh et al (2013) reported that greater leftward asymmetry of myelin content in caudate and anterior frontal cortex was associated with better receptive language skills in healthy children between 1 to 6 years.…”

Section: Discussionmentioning

confidence: 99%

Dissociations among linguistic, cognitive, and auditory-motor neuroanatomical domains in children who stutter

Choo

Burnham

Hicks

et al. 2016

Journal of Communication Disorders

View full text Add to dashboard Cite

The onset of developmental stuttering typically occurs between 2 to 4 years of age, coinciding with a period of rapid development in speech, language, motor and cognitive domains. Previous studies have reported generally poorer performance and uneven, or “dissociated” development across speech and language domains in children who stutter (CWS) relative to children who do not stutter (CWNS)(Anderson, Pellowski, & Conture, 2005). The aim of this study was to replicate and expand previous findings by examining whether CWS exhibit dissociated development across speech-language, cognitive, and motor domains that are also reflected in measures of neuroanatomical development. Participants were 66 CWS (23 females) and 53 CWNS (26 females) ranging from 3 to 10 years. Standardized speech, language, cognitive, and motor skills measures, and fractional anisotropy (FA) values derived from diffusion tensor imaging from speech relevant “dorsal auditory” left perisylvian areas (Hickok & Poeppel, 2007) were analyzed using a correlation-based statistical procedure (Coulter, Anderson, & Conture, 2009) that quantified dissociations across domains. Overall, CWS scored consistently lower on speech, language, cognitive and motor measures, and exhibited dissociated development involving these same measures and white matter neuroanatomical indices relative to CWNS. Boys who stutter exhibited a greater number of dissociations compared to girls who stutter. Results suggest a subgroup of CWS may have incongruent development across multiple domains, and the resolution of this imbalance may be a factor in recovery from stuttering.

show abstract

Functional resting-state connectivity of the human motor network: Differences between right- and left-handers

Cited by 73 publications

References 58 publications

Long-term proper name anomia after removal of the uncinate fasciculus

Long-term proper name anomia after removal of the uncinate fasciculus

Using Bishop’s Card Reaching Task to Assess Hand Preference in 8- to 10-Year-Old Czech Children

Dissociations among linguistic, cognitive, and auditory-motor neuroanatomical domains in children who stutter

Contact Info

Product

Resources

About