Functional reorganization associated with outcome in hand function after stroke revealed by regional homogeneity

Yin, Dazhi; Luo, Yanli; Song, Fan; Xu, Dongrong; Peterson, Bradley S.; Sun, Limin; Men, Weiwei; Xu, Yan; Fan, Mingxia

doi:10.1007/s00234-013-1146-9

Cited by 34 publications

(41 citation statements)

References 47 publications

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“…These findings were consistent with previous studies related to subgroups of stroke patients (Yin et al, 2012;Yin, Luo, et al, 2013a;Yin, Yan, et al, 2013b) Corroborating evidence was also documented in several studies between patients and HCs. In addition, the ReHo values in the bilateral CPL were positively correlated with FMA-HW scores, and that in the contralesional SMA was negatively correlated with FMA-HW scores.…”

Section: Full Band Analysis Of Rehosupporting

confidence: 93%

“…Specifically, in the slow-5 band, compared to the PPH group, we found decreased ReHo in the bilateral CPL and increased ReHo in the contralesional STG in the CPH involving finger-tapping (Loubinoux et al, 2007). Several previous animal studies and lesion studies found that the STG was involved in the parallel organization of the cortico-striatothalamic circuits that support both actual and potential movement (i.e., motor preparation and motor planning) (Alexander, DeLong, & Strick, 1986;Yin, Luo, et al, 2013a). In contrast to M1, the STG cannot directly control movement execution, but this region is a motor-related area.…”

Section: Differences In Reho Between the Two Subgroupsmentioning

confidence: 53%

“…Recently, we used the ReHo method at a frequency band of .01-.08 Hz and detected the alterations in ReHo among stroke subgroups in certain motor-related regions, which were correlated with the FMA-HW scores (Yin et al, 2013a Third, we explored the correlations between ReHo values at the specific frequency bands and the FMA-HW scores of hand function across all the stroke patients. Based on the typical frequency band studies among stroke subgroups (Yin, Luo, et al, 2013a;Yin et al, 2012Yin et al, , 2014 and a subfrequency study between stroke patients and HCs (Zhu et al, 2015), we hypothesized that spontaneous brain activity following stroke would be influenced by both the specific frequency of LFO and the severity of stroke.…”

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confidence: 99%

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Frequency‐specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function

Zhao

Tang

Yin

et al. 2018

Human Brain Mapping

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Emerging evidence has suggested that abnormalities in regional spontaneous brain activity following stroke may be detected by intrinsic low-frequency oscillations (LFO) in resting-state functional MRI (R-fMRI). However, the relationship between hand function outcomes following stroke and local LFO synchronization in different frequency bands is poorly understood. In this study, we performed R-fMRI to examine the regional homogeneity (ReHo) at three different frequency bands (slow-5: .01-.027 Hz; slow-4: .027-.08 Hz; and typical band: .01-.1 Hz) in 26 stroke patients with completely paralyzed hands (CPH) and 26 matched patients with partially paralyzed hands (PPH). Compared to the PPH group, decreased ReHo in the bilateral cerebellum posterior lobes and the contralesional cerebellum anterior lobe was observed in the slow-5 band and the slow-4 band in the CPH group, respectively. The mean ReHo values in these regions were positively correlated with the Fugl-Meyer assessment (FMA) scores. In contrast, increased ReHo in the contralesional supplementary motor area and the contralesional superior temporal gyrus was observed in the slow-4 band and the slow-5 band, respectively. The mean ReHo values in these regions were negatively correlated with the FMA scores. Importantly, significant interactions were identified between the frequency bands and the subgroups of patients in the contralesional precentral gyrus and middle frontal gyrus. These findings indicate that frequency-dependent R-fMRI patterns may serve as potential biomarkers of the neural substrates associated with hand function outcomes following stroke.

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Section: Full Band Analysis Of Rehosupporting

confidence: 93%

Section: Differences In Reho Between the Two Subgroupsmentioning

confidence: 53%

mentioning

confidence: 99%

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Frequency‐specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function

Zhao

Tang

Yin

et al. 2018

Human Brain Mapping

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“…Previous studies examining resting state connectivity following stroke have found correlations in limb motor behavior or motor impairment with resting state connectivity measures (Chen and Schlaug, 2013; Yin etal., 2012; Yin etal., 2013). Here we found significant correlations with expert clinical ratings of AOS severity in the two connections that showed reduced connectivity in the AOS patient group.…”

Section: Discussionmentioning

confidence: 99%

Altered resting-state network connectivity in stroke patients with and without apraxia of speech

New

Robin

Parkinson

et al. 2015

NeuroImage: Clinical

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Motor speech disorders, including apraxia of speech (AOS), account for over 50% of the communication disorders following stroke. Given its prevalence and impact, and the need to understand its neural mechanisms, we used resting state functional MRI to examine functional connectivity within a network of regions previously hypothesized as being associated with AOS (bilateral anterior insula (aINS), inferior frontal gyrus (IFG), and ventral premotor cortex (PM)) in a group of 32 left hemisphere stroke patients and 18 healthy, age-matched controls. Two expert clinicians rated severity of AOS, dysarthria and nonverbal oral apraxia of the patients. Fifteen individuals were categorized as AOS and 17 were AOS-absent. Comparison of connectivity in patients with and without AOS demonstrated that AOS patients had reduced connectivity between bilateral PM, and this reduction correlated with the severity of AOS impairment. In addition, AOS patients had negative connectivity between the left PM and right aINS and this effect decreased with increasing severity of non-verbal oral apraxia. These results highlight left PM involvement in AOS, begin to differentiate its neural mechanisms from those of other motor impairments following stroke, and help inform us of the neural mechanisms driving differences in speech motor planning and programming impairment following stroke.

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“…It has been used in the studies of neurological and psychiatric diseases, including migraine [9], stroke [10], epilepsy [11], neuromyelitis optica [12], Parkinson's Disease [13], attention-deficit hyperactivity disorder [14], AD [4,15], aMCI [3], social anxiety disorder [16], panic disorder [17], blindness [18], depression [19] and schizophrenia [20].…”

Section: Introductionmentioning

confidence: 99%

Regional homogeneity changes in amnestic mild cognitive impairment patients

Yuan

Han

Wei

et al. 2016

Neuroscience Letters

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Functional reorganization associated with outcome in hand function after stroke revealed by regional homogeneity

Abstract: Our study offers a new insight into relationships between functional reorganization and outcomes in hand function after subcortical stroke, and the ReHo method can provide an effective tool for evaluating the efficiency of rehabilitative therapies following stroke.

Cited by 34 publications

References 47 publications

Frequency‐specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function

Frequency‐specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function

Altered resting-state network connectivity in stroke patients with and without apraxia of speech

Regional homogeneity changes in amnestic mild cognitive impairment patients

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