Functional regeneration of ischemic myocardium by transplanted cells overexpressing stromal cell-derived factor-1 (SDF-1): intramyocardial injection versus scaffold-based application

Blumenthal, Britta; Poppe, Annika; Golsong, Peter; Blanke, Philipp; Rylski, Bartosz; Beyersdorf, Friedhelm; Schlensak, Christian; Siepe, Matthias

doi:10.1016/j.ejcts.2011.05.026

Cited by 10 publications

(10 citation statements)

References 25 publications

(51 reference statements)

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“…Zhao et al (2009) found that injection of MSCs overexpressing SDF-1a to the ischemic hearts significantly increased migration of bone marrow derived progenitor cells and greatly enhanced the cardiac regeneration. Others have confirmed functional recovery following the increased migration of the endogenous cells in the case of ischemic myocardium and diabetic wounds after applying of same protocol (Di Rocco et al, 2010;Blumenthal et al, 2011).…”

Section: Injection Of Cells Expressing Ectopic Chemokinementioning

confidence: 82%

Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy

Naderi‐Meshkin

Bahrami

Bidkhori

et al. 2014

Cell Biology International

101

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Stem/progenitor cell-based therapeutic approach in clinical practice has been an elusive dream in medical sciences, and improvement of stem cell homing is one of major challenges in cell therapy programs. Stem/progenitor cells have a homing response to injured tissues/organs, mediated by interactions of chemokine receptors expressed on the cells and chemokines secreted by the injured tissue. For improvement of directed homing of the cells, many techniques have been developed either to engineer stem/progenitor cells with higher amount of chemokine receptors (stem cell-based strategies) or to modulate the target tissues to release higher level of the corresponding chemokines (target tissue-based strategies). This review discusses both of these strategies involved in the improvement of stem cell homing focusing on mesenchymal stem cells as most frequent studied model in cellular therapies.

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Section: Injection Of Cells Expressing Ectopic Chemokinementioning

confidence: 82%

Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy

Naderi‐Meshkin

Bahrami

Bidkhori

et al. 2014

Cell Biology International

101

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“…This strategy has been applied in the treatment of ischemic myocardium through the injection of SDF-1a overexpression primary BMSCs into tissue to promote endogenous bone marrow-derived progenitor migration to the injury site [87]. Furthermore, the strategy has also been used in the therapy of other diseases, such as the treatment of diabetic wounds, which provided essential clues to the promotion of efficacy of bone diseases treatment through improving MSC migration [88] (Table 3). …”

Section: Enhancing Msc Migration Is a New Strategy For Improving Tmentioning

confidence: 99%

Mesenchymal Stem Cell Migration during Bone Formation and Bone Diseases Therapy

Tian

Yang

et al. 2018

IJMS

176

144

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During bone modeling, remodeling, and bone fracture repair, mesenchymal stem cells (MSCs) differentiate into chondrocyte or osteoblast to comply bone formation and regeneration. As multipotent stem cells, MSCs were used to treat bone diseases during the past several decades. However, most of these implications just focused on promoting MSC differentiation. Furthermore, cell migration is also a key issue for bone formation and bone diseases treatment. Abnormal MSC migration could cause different kinds of bone diseases, including osteoporosis. Additionally, for bone disease treatment, the migration of endogenous or exogenous MSCs to bone injury sites is required. Recently, researchers have paid more and more attention to two critical points. One is how to apply MSC migration to bone disease therapy. The other is how to enhance MSC migration to improve the therapeutic efficacy of bone diseases. Some considerable outcomes showed that enhancing MSC migration might be a novel trick for reversing bone loss and other bone diseases, such as osteoporosis, fracture, and osteoarthritis (OA). Although plenty of challenges need to be conquered, application of endogenous and exogenous MSC migration and developing different strategies to improve therapeutic efficacy through enhancing MSC migration to target tissue might be the trend in the future for bone disease treatment.

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“…Although results of initial clinical trials using genetically engineered stem cell therapy are encouraging, many cell survival aspects need to be understood before this approach is fully applied in cardiac repair. A number of pro-survival proteins or angiogenic factors, including connexin Cx43, tumor necrosis factor receptor TNFR, stromal cell-derived factor-1 SDF-1, signaling kinase AKT1, ILK and growth factors HGF, FGF-4 and VEGF-A have been shown to contribute to repopulation of cells when overexpressed in an exact damaged site [78, 175, 209–211]. Other data showed that anti-apoptotic BCL-2 transgene expression can efficiently attenuate cardiomyoblast death early after transplantation [212], and that ERBB4 (erb-b2 receptor tyrosine kinase 4) overexpression potentiate MSC survival in the infarcted heart [213].…”

Section: Improving the Cells For Transplantationmentioning

confidence: 99%

Stem cell death and survival in heart regeneration and repair

Abdelwahid¹,

et al. 2015

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Cardiovascular diseases are major causes of mortality and morbidity. Cardiomyocyte apoptosis disrupts cardiac function and leads to cardiac decompensation and terminal heart failure. Delineating the regulatory signaling pathways that orchestrate cell survival in the heart has significant therapeutic implications. Cardiac tissue has limited capacity to regenerate and repair. Stem cell therapy is a successful approach for repairing and regenerating ischemic cardiac tissue; however, transplanted cells display very high death percentage, a problem that affects success of tissue regeneration. Stem cells display multipotency or pluripotency and undergo self-renewal, however these events are negatively influenced by upregulation of cell death machinery that induces the significant decrease in survival and differentiation signals upon cardiovascular injury. While efforts to identify cell types and molecular pathways that promote cardiac tissue regeneration have been productive, studies that focus on blocking the extensive cell death after transplantation are limited. The control of cell death includes multiple networks rather than one crucial pathway, which underlies the challenge of identifying the interaction between various cellular and biochemical components. This review is aimed at exploiting the molecular mechanisms by which stem cells resist death signals to develop into mature and healthy cardiac cells. Specifically, we focus on a number of factors that control death and survival of stem cells upon transplantation and ultimately affect cardiac regeneration. We also discuss potential survival enhancing strategies and how they could be meaningful in the design of targeted therapies that improve cardiac function.

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Functional regeneration of ischemic myocardium by transplanted cells overexpressing stromal cell-derived factor-1 (SDF-1): intramyocardial injection versus scaffold-based application

Abstract: Transplantation of myoblasts overexpressing SDF-1 improves cardiac function after MI. The restoration of hemodynamic parameters is accompanied by a reduction in infarction size. This reverse remodeling capacity is independent of a scaffold-based application of the SDF-1-transfected cells.

Cited by 10 publications

References 25 publications

Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy

Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy

Mesenchymal Stem Cell Migration during Bone Formation and Bone Diseases Therapy

Stem cell death and survival in heart regeneration and repair

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