Functional redundancy of the Notch pathway in ovarian cancer cell lines

Silva, Fernanda; Félix, Ana; Serpa, Jacinta

doi:10.3892/ol.2016.4959

Cited by 9 publications

(6 citation statements)

References 41 publications

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“…Histone deacetylase (HDAC) inhibitors induce growth arrest and apoptosis via modulating multiple pathways in cancer cell lines; however, these inhibitors can also lead to Notch activation that partially attenuates their antitumor activities in return. 34 , 35 This side effect was speculated to be redundant in the tumor cells where the Notch signaling has already been strongly activated. This hypothesis was supported, to some extent, by the association between a high Notch-score and sensitivities to HDAC inhibitors, such as vorinostat (Q < 0.001) and entinostat (Q < 0.001, Figure 4 G).…”

Section: Resultsmentioning

confidence: 99%

Notch activation defines immune-suppressive subsets of ccRCCs with unfavorable benefits from immunotherapy over VEGFR/mTOR inhibitors

Han,

Xu,

Chen

et al. 2024

iScience

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Section: Resultsmentioning

confidence: 99%

Notch activation defines immune-suppressive subsets of ccRCCs with unfavorable benefits from immunotherapy over VEGFR/mTOR inhibitors

Han,

Xu,

Chen

et al. 2024

iScience

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“…Topotecan is indicated for metastatic advanced OV that has failed chemotherapy. Paclitaxel, vorinostat and other drugs are associated with OV treatment [27,28].…”

Section: Drugs Predictions Of Signature Genesmentioning

confidence: 99%

Construction of an Immunity and Ferroptosis-Related Risk Score Model to Predict Ovarian Cancer Clinical Outcomes and Immune Microenvironment

Wei¹,

Zhao²,

Gao³

et al. 2023

Front. Biosci. (Landmark Ed)

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Background: Ovarian cancer (OV) is a severe and common gynecological disease. Ferroptosis can regulate the progression and invasion of tumors. The immune system is a decisive factor in cancer. The present study aimed to use gene expression data to establish an immunity and ferroptosis-related risk score model as a prognostic biomarker to predict clinical outcomes and the immune microenvironment of OV. Methods: Common gene expression data were searched from the Gene Expression Omnibus and The Cancer Genome Atlas databases. Immunity-related genes and ferroptosis-related genes were searched and downloaded from the ImmPort and FerrDb databases, followed by the analysis of the overall survival of patients with OV and the identification of genes. Subsequently, the status of the infiltration of immune cells and the association between immune checkpoints and risk score were assessed. Results: A total of 10 prognostic genes (C5AR1, GZMB, IGF2R, ISG20, PPP3CA, STAT1, TRIM27, TSHR, RB1, and EGFR) were included in the immunity and ferroptosisrelated risk score model. The high-risk group had a higher infiltration of immune cells. The risk score, an independent prognostic feature of OV was negatively associated with each immune checkpoint. The risk score may thus help to predict the response to immunotherapy. Conclusions: The immunity and ferroptosis-related risk score model is an independent prognostic factor for OV. The established risk score may help to predict the response of patients to immunotherapy.

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“…Notch Signaling Pathway. Notch and its intracellular domain (NICD) have been shown to be overexpressed in OC, and this is closely related to poorer prognosis in patients with OC [149][150][151][152]. OC cells in which Notch is activated show resistance to carboplatin, and it has been reported that methylseleninic acid can synergistically enhance the killing effect of carboplatin on OVCA429/NICD3 OC cells (which have a constitutively active form of Notch3) and that this can be promoted by ROS [153].…”

Section: Keap1-nrf2mentioning

confidence: 99%

Insights into the Role of Oxidative Stress in Ovarian Cancer

Ding

Xie

Shen

et al. 2021

Oxidative Medicine and Cellular Longevity

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Oxidative stress (OS) arises when the body is subjected to harmful endogenous or exogenous factors that overwhelm the antioxidant system. There is increasing evidence that OS is involved in a number of diseases, including ovarian cancer (OC). OC is the most lethal gynecological malignancy, and risk factors include genetic factors, age, infertility, nulliparity, microbial infections, obesity, smoking, etc. OS can promote the proliferation, metastasis, and therapy resistance of OC, while high levels of OS have cytotoxic effects and induce apoptosis in OC cells. This review focuses on the relationship between OS and the development of OC from four aspects: genetic alterations, signaling pathways, transcription factors, and the tumor microenvironment. Furthermore, strategies to target aberrant OS in OC are summarized and discussed, with a view to providing new ideas for clinical treatment.

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Functional redundancy of the Notch pathway in ovarian cancer cell lines

Cited by 9 publications

References 41 publications

Notch activation defines immune-suppressive subsets of ccRCCs with unfavorable benefits from immunotherapy over VEGFR/mTOR inhibitors

Notch activation defines immune-suppressive subsets of ccRCCs with unfavorable benefits from immunotherapy over VEGFR/mTOR inhibitors

Construction of an Immunity and Ferroptosis-Related Risk Score Model to Predict Ovarian Cancer Clinical Outcomes and Immune Microenvironment

Insights into the Role of Oxidative Stress in Ovarian Cancer

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