Functional recovery of the gustatory system after sodium deprivation during development: how much sodium and where

Przekop, Peter; Mook, Douglas G.; Hill, David L.

doi:10.1152/ajpregu.1990.259.4.r786

Cited by 21 publications

(12 citation statements)

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“…However, the absorption of sodium is a necessary condition for recovery to occur. Taste stimulation alone fails to restore function (Przekop et al, 1990). …”

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confidence: 99%

The effects of dietary protein restriction on chorda tympani nerve taste responses and terminal field organization

Thomas

Hill

2008

Neuroscience

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Prenatal dietary sodium restriction produces profound developmental effects on rat functional taste responses and formation of neural circuits in the brainstem. Converging evidence indicates that the underlying mechanisms for these effects are related to a compromised nutritional state and not to direct stimulus-receptor interactions. We explored whether early malnourishment produces similar functional and structural effects to those seen following dietary sodium restriction by using a protein deficient, sodium replete diet. To determine if early dietary protein-restriction affects the development of the peripheral gustatory system, multi-fiber neurophysiological recordings were made from the chorda tympani nerve and anterograde track tracing of the chorda tympani nerve into the nucleus of the solitary tract (NTS) was accomplished in rats fed a protein-restricted or a control diet (6% and 20%, respectively). The dietary regimens began on embryonic day 7 and continued until rats were used for neurophysiological recordings (postnatal days (P) 35-50) or for chorda tympani terminal field labeling (P40-50). Responses to a concentration series of NaCl, sodium acetate, KCl, and to 0.50 M sucrose, 0.03 M quinine-HCl, and 0.01 N HCl revealed attenuated responses (30-60%) to sodium-specific stimuli in rats fed the 6% protein diet compared with those fed the 20% protein diet. Responses to all other stimuli were similar between groups. Terminal field volumes were nearly twofold larger in protein-restricted rats compared with controls, with the differences located primarily in the dorsal-caudal zone of the terminal field. These results are similar to the results seen previously in rats fed a sodium-restricted diet throughout pre-and postnatal development, suggesting that dietary sodium-and protein-restriction share similar mechanisms in altering gustatory development. Keywordsnucleus of the solitary tract; gustation; development; prenatal diet; plasticity . E-mail address: dh2t@virginia.edu (D. L. Hill). Publisher's Disclaimer: This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: http://www.elsevier.com/copyright NIH Public Access Sensory systems adapt to environmental influences by coordinated alterations in structure and function, often referred to as "plastic" changes. Unlike other sensory systems, there is a remarkable amount of environmentally induced plasticity resident in peripheral and brainstem g...

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“…However, the absorption of sodium is a necessary condition for recovery to occur. Taste stimulation alone fails to restore function (Przekop et al, 1990). …”

mentioning

confidence: 99%

The effects of dietary protein restriction on chorda tympani nerve taste responses and terminal field organization

Thomas

Hill

2008

Neuroscience

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“…In this respect, we note that alterations in gustatory nerve responses to sodium chloride are apparent in pups born to sodium-restricted mothers but can be completely reversed if pups are transferred to a sodium-replete diet in the postnatal period [36,37]. If avidity for calcium is regulated similarly then exposure to calcium-replete diet may have reversed any transient alterations in gustatory functions caused by early experience.…”

Section: Discussionmentioning

confidence: 99%

Influence of cross-fostering on preference for calcium chloride in C57BL/6J and PWK/PhJ mice

Voznesenskaya

Tordoff

2013

Physiology & Behavior

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We investigated whether maternal influences during the suckling period alter the avidity for calcium, using as models mice from the calcium-preferring PWK/PhJ strain and the calcium-avoiding C57BL/6J strain. We found that milk collected from PWK/PhJ dams had higher calcium concentrations than did milk collected from C57BL/6J dams. Despite this, cross-strain fostering had no effect on adult calcium preferences relative to mice of the same strain that were within-strain fostered or not fostered. Our results indicate that calcium avoidance by C57BL/6J mice and acceptance by PWK/PhJ mice is unaffected by maternal environment during the suckling period.

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“…If sodium-restricted rats are allowed to drink physiological saline sufficient to produce recovery, but are not allowed to absorb sodium due to a preinjection of the diuretic drug furosemide, they do not recover normal chorda tympani function. 38 Therefore, as emphasized earlier for normal development, the sodium transducer is not under control of stimulation of the receptor with sodium, but is probably under control of regulatory factors released following absorption. As with recovery via ingestion of food, there is a period of 10 to 12 days needed for recovery following sodium ingestion.…”

Section: Developmental Dietary Sodium Restriction and Its Effect On Tmentioning

confidence: 91%

“…When a sodium-replete diet is restored in restricted rats at any time postnatally, chorda tympani responses recover to control levels in about 15 days, with a corresponding increase in functional ENaCs. 29 A single, 30-mL ingestive bout of physiological saline is also sufficient to recover sodium taste responses, 38,39 and this recovery is not dependent on direct stimulation of taste receptor cells with sodium. If sodium-restricted rats are allowed to drink physiological saline sufficient to produce recovery, but are not allowed to absorb sodium due to a preinjection of the diuretic drug furosemide, they do not recover normal chorda tympani function.…”

Section: Developmental Dietary Sodium Restriction and Its Effect On Tmentioning

confidence: 99%

Neural Plasticity in the Gustatory System

Hill

2004

Nutrition Reviews

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Sensory systems adapt to changing environmental influences by coordinated alterations in structure and function. These alterations are referred to as plastic changes. The gustatory system displays numerous plastic changes even in receptor cells. This review focuses on the plasticity of gustatory structures through the first synaptic relay in the brain. Unlike other sensory systems, there is a remarkable amount of environmentally induced changes in these peripheral-most neural structures. The most consistent and largest changes occur to stimuli that also impact on homeostatic systems, especially when the environmental manipulation is instituted during early development.

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Functional recovery of the gustatory system after sodium deprivation during development: how much sodium and where

Cited by 21 publications

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The effects of dietary protein restriction on chorda tympani nerve taste responses and terminal field organization

The effects of dietary protein restriction on chorda tympani nerve taste responses and terminal field organization

Influence of cross-fostering on preference for calcium chloride in C57BL/6J and PWK/PhJ mice

Neural Plasticity in the Gustatory System

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