Functional recovery after peripheral nerve injury and implantation of a collagen guide

Alluin, Olivier; Wittmann, Catherine; Marqueste, Tanguy; Chabas, Jean-François; García, Stéphane; Lavaut, Marie‐Noëlle; Guinard, D.; Féron, François; Decherchi, Patrick

doi:10.1016/j.biomaterials.2008.09.043

Cited by 144 publications

(113 citation statements)

References 60 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…This combination has so far only been used for the reconstruction of short rat peroneal nerve defects. 23 Muscle tissue has been successfully used as a physical guidance structure for peripheral nerve regeneration both in animals and humans. [12][13][14] Pretreatment is intended to provide an open extracellular network of coaxially alligned muscle basal lamina tubes to serve as a temporary scaffold supporting guided axonal growth.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Peripheral nerve reconstruction with collagen tubes filled with denatured autologous muscle tissue in the rat model

et al. 2011

View full text Add to dashboard Cite

Conventional nerve conduits lack cellular and extracellular guidance structures critical for bridging larger defects. In this study, an exogenous matrix for axonal regeneration was provided by pretreated muscle tissue. In 24 rats, 14-mm sciatic nerve segments were resected and surgically reconstructed using one of the following methods: autograft (AG); bovine type I collagen conduit; (MDM) collagen tube filled with modified denatured autologous muscle tissue. For 8 weeks, functional regeneration was evaluated by footprint and video gait analysis. Evaluation was complemented by electrophysiology, as well as qualitative and quantitative structural assessment of nerves and target muscles. Group AG was superior both structurally and functionally, showing higher axon counts, a more normal gait pattern, and less severe muscle atrophy. Fiber quality (fiber size and myelin thickness) was highest in group MDM, possibly related to the myelin-producing effect of muscular laminin. However, axon count was lowest in this group, and ultrastructural analysis of the denatured muscle tissue showed areas of incomplete denaturation that had acted as a mechanical barrier for regenerating axons. In light of these results, the often advocated use of muscular exogenous matrix for peripheral nerve reconstruction is reviewed in the literature, and its clinical application is critically discussed. In conclusion, combined muscle tubes may have a positive influence on nerve fiber maturation. However, muscle pretreatment is not without risks, and denaturation processes need to be further refined.

show abstract

Section: Discussionmentioning

confidence: 99%

“…So far, the combination of collagen tube and pretreated muscle tissue for peripheral nerve reconstruction has only been described for short (10 mm) peroneal nerve defects. 23 …”

mentioning

confidence: 97%

Peripheral nerve reconstruction with collagen tubes filled with denatured autologous muscle tissue in the rat model

et al. 2011

View full text Add to dashboard Cite

show abstract

“…95,99,[178][179][180] The natural materials include the veins, skeletal muscle fibrils and collagen. 105,111,112,178 The synthetic materials include the silicone, polyglycolic acid (PGA), polilactic acid (PLA), poly-L-lactide-co-glicolide (PLGA), poli-e-caprolactone (PCL), poly-lactide-co-caprolactone (PLC) and poly-3-hydroxybutyrate (PHB). 96,87,91,101,107,108,167,169,178 The success rate of autologous vein grafts is minimal especially in the long nerve defects.…”

Section: Intraluminal Conduit Components/scaffoldsmentioning

confidence: 99%

“…Collagen. Collagen is the major component of the extracellular matrix and is known to promote cellular proliferation and tissue healing 7,8,61,83,96,105,111,112,[157][158][159] Several investigators indicate that as a material for nerve conduits; collagen possesses superior biologic properties for peripheral nerve regeneration. 30 126 Polyglycolic acid.…”

Section: Biodegradable Synthetic Materialsmentioning

confidence: 99%

Regeneration and repair of peripheral nerves with different biomaterials: Review

2010

View full text Add to dashboard Cite

Peripheral nerve injury may cause gaps between the nerve stumps. Axonal proliferation in nerve conduits is limited to 10-15 mm. Most of the supportive research has been done on rat or mouse models which are different from humans. Herein we review autografts and biomaterials which are commonly used for nerve gap repair and their respective outcomes. Nerve autografting has been the first choice for repairing peripheral nerve gaps. However, it has been demonstrated experimentally that tissue engineered tubes can also permit lead to effective nerve repair over gaps longer than 4 cm repair that was previously thought to be restorable by means of nerve graft only. All of the discoveries in the nerve armamentarium are making their way into the clinic, where they are, showing great potential for improving both the extent and rate of functional recovery compared with alternative nerve guides.

show abstract

“…Despite providing a number of advantages for repair, success in the clinic has been limited. This is partly due to a number of the intrinsic limitations of the gold standard, particularly nerve and axonal size mismatches between the donor nerve and the targeted injured nerve [6,9]. In addition there is a requirement for a second surgical site i.e.…”

Section: Introductionmentioning

confidence: 99%

The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair

et al. 2012

View full text Add to dashboard Cite

Publication InformationDaly, WT,Yao, L,Abu-rub, MT,O'Connell, C,Zeugolis, DI,Windebank, AJ,Pandit, AS (2012) b s t r a c tThe current microsurgical gold standard for repairing long gap nerve injuries is the autograft. Autograft provides a protective environment for repair and a natural internal architecture, which is essential for regeneration. Current clinically approved hollow nerve guidance conduits allow provision of this protective environment; however they fail to provide an essential internal architecture to the regenerating nerve. In the present study both structured and unstructured intraluminal collagen fibres are investigated to assess their ability to enhance conduit mediated nerve repair. This study presents a direct comparison of both structured and unstructured fibres in vivo. The addition of intraluminal guidance structures was shown to significantly decrease axonal dispersion within the conduit and reduced axonal mismatch of distal nerve targets (p < 0.05). The intraluminal fibres were shown to be successfully incorporated into the host regenerative process, acting as a platform for Schwann cell migration and axonal regeneration. Ultimately the fibres were able to provide a platform for nerve regeneration in a long term regeneration study (16 weeks) and facilitated increased guidance of regenerating axons towards their distal nerve targets.

show abstract

Functional recovery after peripheral nerve injury and implantation of a collagen guide

Cited by 144 publications

References 60 publications

Peripheral nerve reconstruction with collagen tubes filled with denatured autologous muscle tissue in the rat model

Peripheral nerve reconstruction with collagen tubes filled with denatured autologous muscle tissue in the rat model

Regeneration and repair of peripheral nerves with different biomaterials: Review

The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair

Contact Info

Product

Resources

About