Functional Radiotherapy Targeting using Focused Dose Escalation

Alonzi, R.

doi:10.1016/j.clon.2015.06.015

Cited by 16 publications

(16 citation statements)

References 104 publications

(51 reference statements)

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“…If biological planning is applied, experience with mpTRUS (multi-parametric transrectal ultrasound) is necessary in the real-time planning procedure. [4,[16][17][18][19][20] Furthermore, in many situations, the medical oncologist can offer invaluable help in systematic treatment decisions. Additionally, we need the cooperation of a pathology and anesthesia expert.…”

Section: Discussionmentioning

confidence: 99%

“…A potential way to avoid this is to use techniques to focus the escalated dose to the high-risk regions. [18,20,16] Additionally, in a high workload IRT department HDR brachytherapy treatments are more economical. [42][43][44] Added value is the advantage of IRT using the possibility of multiple and repeated applications due to the small volume normal tissue irradiation.…”

Section: Discussionmentioning

confidence: 99%

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Interventional Oncology: Should Interventional Radiotherapy (Brachytherapy) be Integrated into Modern Treatment Procedures?

Kovács¹

2019

TJ Oncol

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The delivery of a very high dose by radiotherapy to a dedicated target with minimal surrounding normal tissue dose is a challenging situation. From a radiotherapy point of view, in several anatomic situations, the most optimal method is the use of interventional radiotherapy (brachytherapy; IRT) alone or in combination with other established interventional tumor cell eliminating methods. METHODS First, Interventional Radiotherapy, Interventional Radiology, Interventional Endoscopy and Interventional Chemotherapy have the same aim of eliminating tumor tissue. Second, target definition and some IRT application techniques need multidisciplinary teamwork. RESULTS Multidisciplinary teams have the best potential to offer the best possible cure in localized solid tumors or in selected oligometastatic disease. Examples for this kind of service are given for H&N-, anal-, vaginal-, breast-, prostate cancers as well as in oligometastatic disease. The combined use of interventional tumor ablation techniques is demonstrated. CONCLUSION Interventional Oncology has the potential to improve the treatment results in localized solid cancers or in selected oligometastatic disease, and large workload Interventional Oncology Centers could have an important role in the patient service, in the education as well as in the clinical research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interventional Oncology: Should Interventional Radiotherapy (Brachytherapy) be Integrated into Modern Treatment Procedures?

Kovács¹

2019

TJ Oncol

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“…1 However, a subset of human malignancies fails to respond to radiotherapy, as they are resistant to radiation-induced apoptosis. 1,2 Thus, the identification of novel mechanisms of resistance to radiation may aid to overcome radioresistance, improve radiotherapy efficacy and, ultimately, personalize treatments. 2 Preoperative chemoradiation is currently the standard of care for locally advanced rectal adenocarcinoma, obtaining tumor downstaging and lower rates of local failure.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Thus, the identification of novel mechanisms of resistance to radiation may aid to overcome radioresistance, improve radiotherapy efficacy and, ultimately, personalize treatments. 2 Preoperative chemoradiation is currently the standard of care for locally advanced rectal adenocarcinoma, obtaining tumor downstaging and lower rates of local failure. 3 Indeed, total mesorectal excision is curative for small rectal tumors, but the risk of locoregional recurrence, distant metastasis, and death increases with tumors extending through the muscularis propria (tumor-nodes-metastasis (TNM), T3 or T4) or with nodal involvement (TNM, N1 or N2).…”

Section: Introductionmentioning

confidence: 99%

Cyclin-dependent kinase 1 targeting improves sensitivity to radiation in BRAF V600E colorectal carcinoma cells

et al. 2018

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Objectives: Preoperative chemoradiation is currently the standard of care in locally advanced rectal carcinoma, even though a subset of rectal tumors does not achieve major clinically meaningful responses upon neoadjuvant chemoradiation. At present, no molecular biomarkers are available to predict response to neoadjuvant chemoradiation and select resistant tumors willing more intense therapeutic strategies. Thus, BRAF mutational status was investigated for its role in favoring resistance to radiation in colorectal carcinoma cell lines and cyclin-dependent kinase 1 as a target to improve radiosensitivity in BRAF V600E colorectal tumor cells. Methods: Colony-forming assay and apoptotic rates were evaluated to compare the sensitivity of different colon carcinoma cell lines to ionizing radiation and their radiosensitivity upon exposure to BRAF and/or cyclin-dependent kinase 1 inhibitory/silencing strategies. Cyclin-dependent kinase 1 expression/subcellular distribution was studied by immunoblot analysis. Results: Colon carcinoma BRAF V600E HT29 cells exhibited poor response to radiation compared to BRAF wild-type COLO320 and HCT116 cells. Interestingly, neither radiosensitizing doses of 5-fluoruracil nor BRAF inhibition/silencing significantly improved radiosensitivity in HT29 cells. Of note, poor response to radiation correlated with upregulation/ relocation of cyclin-dependent kinase 1 in mitochondria. Consistently, cyclin-dependent kinase 1 inhibition/silencing as well as its targeting, through inhibition of HSP90 quality control pathway, significantly inhibited the clonogenic ability and increased apoptotic rates in HT29 cells upon exposure to radiation. Conclusion: These data suggest that BRAF V600E colorectal carcinoma cells are poorly responsive to radiation, and cyclin-dependent kinase 1 represents a target to improve radiosensitivity in BRAF V600E colorectal tumor cells.

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“…Imaging at baseline may provide additional prognostic and potentially predictive data [9]. Spatial information may be used in target volume selection [10,11] and in addition has led to the concept of a 'biological target volume' [1,11] (the use of functional imaging in tumour targeting and dose painting strategies is beyond the scope of this review and is covered elsewhere in this special issue [12]). In addition, it is recognised that tumours respond variably during a course of fractionated radiotherapy [13].…”

Section: Introductionmentioning

confidence: 99%

Functional Imaging Biomarkers: Potential to Guide an Individualised Approach to Radiotherapy

Prestwich¹,

Vaidyanathan²,

Scarsbrook³

2015

Clinical Oncology

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Functional Radiotherapy Targeting using Focused Dose Escalation

Cited by 16 publications

References 104 publications

Interventional Oncology: Should Interventional Radiotherapy (Brachytherapy) be Integrated into Modern Treatment Procedures?

Interventional Oncology: Should Interventional Radiotherapy (Brachytherapy) be Integrated into Modern Treatment Procedures?

Cyclin-dependent kinase 1 targeting improves sensitivity to radiation in BRAF V600E colorectal carcinoma cells

Functional Imaging Biomarkers: Potential to Guide an Individualised Approach to Radiotherapy

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