Functional, radiological and biological markers of alveolitis and infections of the lower respiratory tract in patients with systemic sclerosis

Santis, Maria De; Bosello, Silvia Laura; Torre, Giuseppe La; Capuano, Anna; Tolusso, Barbara; Pagliari, Gabriella; Pistelli, Riccardo; Danza, Francesco; Zoli, Angelo; Ferraccioli, Gianfranco

doi:10.1186/1465-9921-6-96

Cited by 70 publications

(60 citation statements)

References 38 publications

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“…1). This matches the results of De Santis et al [30] study. Although they used a different HRCT scoring system as described by Kazerooni et al [31] They demonstrated a significantly positive correlation between HRCT score and IL-6 plasma level (r = 0.36, P = 0.0012) suggesting that patients with a greater extent of lung affection on HRCT had a more aggressive disease.…”

Section: Discussionsupporting

confidence: 95%

Interleukin-6 in systemic sclerosis and potential correlation with pulmonary involvement

Yousif¹,

Habib²,

Esaely³

et al. 2015

Egyptian Journal of Chest Diseases and Tuberculosis

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Background: A progressive pulmonary involvement is frequent in systemic sclerosis and it is the leading cause of morbidity and mortality. IL-6 has been implicated in the pathogenesis of systemic sclerosis via stimulation of fibroblasts to produce excess collagen and glycosaminoglycan. Specific correlation between IL-6 and lung involvement have not been found yet.Aim: To study the possible correlation between lung involvement (assessed by spirometry and HRCT abnormalities) and the serum level of IL-6.Subjects and methods: 20 patients with scleroderma compared with 20 matched volunteers as control group. All participants underwent spirometry, HRCT scan and serum IL-6 measurements. HRCT signs were scored according to Warrick et al. score for systemic sclerosis.Results: Patients showed a statistically significant reduction in FVC%, FEF 25-75% and significantly higher ESR and IL-6 compared to control. There was a highly significant positive correlation between the total HRCT score and serum IL-6.Conclusion: Serum IL-6 could be a marker of the degree of pulmonary involvement in patients with systemic sclerosis.

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Section: Discussionsupporting

confidence: 95%

Interleukin-6 in systemic sclerosis and potential correlation with pulmonary involvement

Yousif¹,

Habib²,

Esaely³

et al. 2015

Egyptian Journal of Chest Diseases and Tuberculosis

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“…When assessing each abnormality separately, fibrosis scores were again correlated with low FVC, DLCO and TLC. One study reported correlation between ground-glass disease and pulmonary function test abnormalities [37]. In contrast, in the Scleroderma Lung Study, pure ground-glass disease did not correlate well with pulmonary function tests, but was associated with evidence of alveolitis on bronchoalveolar lavage, albeit weakly [27].…”

Section: Validitymentioning

confidence: 91%

High Resolution Computed Tomography Scoring Systems for Evaluating Interstitial Lung Disease in Systemic Sclerosis Patients

Assayag¹,

Kaduri²,

Hudson³

2012

Rheumatology

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Interstitial lung disease commonly develops in patients with Systemic sclerosis (SSc). High resolution computed tomography (HRCT) has become the gold standard for detection and evaluation of lung involvement in SSc. Several HRCT scoring methods have been described and used to characterize and quantify the disease. This article reviews the different scoring systems and how they have been validated clinically and applied to prognosticate patients, assess disease progression and evaluate response to treatment.

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“…SSc-ILD is present on HRCT in over 50 % of SSc patients and in over 90 % of SSc patients with abnormal PFTs [49,50]. HRCT appearances usually consist of a variable combination of ground-glass attenuation and fine reticulation.…”

Section: Approved and Novel Therapies Of Ssc-pahmentioning

confidence: 99%

Management of Scleroderma-Associated Pulmonary Involvement

Dobrotă

Distler

Wells

et al. 2015

Curr Treat Options in Rheum

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Functional, radiological and biological markers of alveolitis and infections of the lower respiratory tract in patients with systemic sclerosis

Abstract: Background: A progressive lung disease and a worse survival have been observed in patients with systemic sclerosis and alveolitis. The objective of this study was to define the functional, radiological and biological markers of alveolitis in SSc patients.

Cited by 70 publications

References 38 publications

Interleukin-6 in systemic sclerosis and potential correlation with pulmonary involvement

Interleukin-6 in systemic sclerosis and potential correlation with pulmonary involvement

High Resolution Computed Tomography Scoring Systems for Evaluating Interstitial Lung Disease in Systemic Sclerosis Patients

Management of Scleroderma-Associated Pulmonary Involvement

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