Functional Properties of Human Cytomegalovirus Hyperimmunoglobulin and Standard Immunoglobulin Preparations

Germer, Matthias; Herbener, Peter; Schüttrumpf, Jörg

doi:10.12659/aot.898050

Cited by 16 publications

(24 citation statements)

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“…In vitro studies show consistently enhanced functional antibody against CMV compared to regular intravenous immune globulin. 245,246 Monoclonal antibodies are in development and show potential promise for reduction of CMV DNAemia and disease. 247,248…”

Section: Immune Globulinmentioning

confidence: 99%

The Third International Consensus Guidelines on the Management of Cytomegalovirus in Solid-organ Transplantation

et al. 2018

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Despite recent advances, cytomegalovirus (CMV) infections remain one of the most common complications affecting solid organ transplant recipients, conveying higher risks of complications, graft loss, morbidity, and mortality. Research in the field and development of prior consensus guidelines supported by The Transplantation Society has allowed a more standardized approach to CMV management. An international multidisciplinary panel of experts was convened to expand and revise evidence and expert opinion-based consensus guidelines on CMV management including prevention, treatment, diagnostics, immunology, drug resistance, and pediatric issues. Highlights include advances in molecular and immunologic diagnostics, improved understanding of diagnostic thresholds, optimized methods of prevention, advances in the use of novel antiviral therapies and certain immunosuppressive agents, and more savvy approaches to treatment resistant/refractory disease. The following report summarizes the updated recommendations.

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Section: Immune Globulinmentioning

confidence: 99%

The Third International Consensus Guidelines on the Management of Cytomegalovirus in Solid-organ Transplantation

et al. 2018

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“…In addition to the that not all part or sequences of CM2 antigen trigger or stimulate the immune system and mainly humeral immune response. It is known that the central part of pUL57 is a major reactive protein during acute HCMV infection [16,17].…”

Section: Discussionmentioning

confidence: 99%

The role of IFN-gamma in Humoral immune response for HCMV antigens among pregnant women

Qader

Tawfiq²

2020

Al-Kitab J. for Pure Sci.

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Background: Human cytomegalovirus (HCMV) is a highly host-specific virus belongs to the βherpesvirus subfamily, which is a leading cause of congenital infections. The immune cytokines such as Interferons-gama (IFN- ) may have direct inhibitory effects on HCMV replication and control of viral infections. Aim of the study: This research aims at determining the specificity of anti-HCMV antibodies for different HCMV antigens in relation to serum INF- levels. Materials & Methods: A cross sectional study was carried out in Kirkuk governorate from April 2018 to June 2019. The number of pregnant women understudy was 400 women presented to some private medical laboratories. The pregnant women were examined for the seroprevalence of HCMVIgM and IgG by using ECLIA technique then their specificities determined for different HCMV antigens by using line immune assay, In addition to estimation the level of serum INF- levels by using ELISA technique. Results: The rate of HCMV-IgG , HCMV-IgM and both HCMV-IgG and IgM at the same time were 288(72 %), 32(8%) and 18(4.5%) respectively. Regarding the specificity of the determined HCMVIgM to various HCMV antigens (IE1, CM2, p150, p65, gB1 and gB2), the highest rate of HCMVIgG was 96.25% specific for gB1 antigen, while highest rate of HCMV-IgM were 96.87% specific gB1 and p150 antigen. Considering the specificity of these antibodies for the examined antigens in relation to serum INF- levels, the highest of pregnant women with increased INF- level had antibodies for IE1 antigen. Conclusions: There was significant relation of the serum INF- level with specificity of anti-HCMV antibodies to divers HCMV antigens.

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“…Hyperimmune plasma for Cytogam and Cytotect (CMVIgG) is selected from normal human plasma from qualified blood or plasma donors [54,90]. Although an estimated 49-74% of adults (aged 20-59) in the US are seropositive for CMV [91], antibody levels are variable.…”

Section: Polyclonal Antibody Therapymentioning

confidence: 99%

“…Cytotect is also purified using ethanol fractionation. Both products are formulated as a 5% IgG; Cytogam is stabilized with 5% sucrose [54] and Cytotect with glycine [90]. As for most antiviral HIG products, the potency of these products is measured using a neutralization assay.…”

Section: Polyclonal Antibody Therapymentioning

confidence: 99%

“…There have been episodic publications suggesting that normal IG products could substitute for hyperimmune CMVIG products [95][96][97] because CMV seropositivity is common. Direct comparisons of CMVIgG with non-hyperimmune products have shown that the former have consistently higher levels of anti-CMV antibodies and neutralizing activity compared with intravenous IgG preparations [90,98,99].…”

Section: Polyclonal Antibody Therapymentioning

confidence: 99%

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Immune Prophylaxis and Therapy for Human Cytomegalovirus Infection

Struble¹,

Murata

Komatsu

et al. 2021

IJMS

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Human Cytomegalovirus (HCMV) infection is widespread and can result in severe sequelae in susceptible populations. Primary HCMV infection of naïve individuals results in life-long latency characterized by frequent and sporadic reactivations. HCMV infection elicits a robust antibody response, including neutralizing antibodies that can block the infection of susceptible cells in vitro and in vivo. Thus, antibody products and vaccines hold great promise for the prevention and treatment of HCMV, but to date, most attempts to demonstrate their safety and efficacy in clinical trials have been unsuccessful. In this review we summarize publicly available data on these products and highlight new developments and approaches that could assist in successful translation of HCMV immunotherapies.

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Functional Properties of Human Cytomegalovirus Hyperimmunoglobulin and Standard Immunoglobulin Preparations

Cited by 16 publications

References 0 publications

The Third International Consensus Guidelines on the Management of Cytomegalovirus in Solid-organ Transplantation

The Third International Consensus Guidelines on the Management of Cytomegalovirus in Solid-organ Transplantation

The role of IFN-gamma in Humoral immune response for HCMV antigens among pregnant women

Immune Prophylaxis and Therapy for Human Cytomegalovirus Infection

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