This study investigates the proximate composition, mineral content, phytochemical constituents and antioxidant activity of Parkia biglobosa, Prosopis Africana, Monodora myristica and Pimpinella anisum seeds collected from Kogi state, Nigeria using standard analytical methods. The results indicated that there were significant differences (P≤0.05) in the spice samples. However, it was revealed that Parkia biglobosa had the highest crude fat (17.87±0.02 %) and crude protein content (26.23±0.02 %). Pimpinella anisum had the highest crude fibre content (12.74±0.08 %) while Monodora myristica had the lowest moisture content (10.54±0.23 %) as well as the highest ash (5.55±0.04) and carbohydrate content (50.14±4.30 %). The presence of phytochemical compounds was detected in the spice samples at various amounts. Phytates, flavonoids, oxalates and phenols were most abundant in Parkia biglobosa. Tannins and alkaloids were most abundant in Prosopis Africana, while saponins were most abundant in Monodora myristica. The mineral analysis in mg/100g indicated that the spices contained appreciable levels of essential minerals, with Monodora myristica having the highest calcium, magnesium, potassium, phosphorous and iron concentration of 140.01±0.11 mg/100g, 88.15±0.24 mg/100g, 90.94±0.19 mg/100g, 124.56±0.18 mg/100g and 21.00±0.12 mg/100g respectively. While Parkia biglobosa has the highest concentration of sodium at 36.08±0.07. The samples also showed great antioxidant activity, with Parkia biglobosa showing the most activity at various concentrations. From the result, it is evident that these selected indigenous spice samples are rich sources of both nutritional and pharmaceutical properties required by man.