Functional Properties of Cancer Epithelium and Stroma-Derived Exosomes in Head and Neck Squamous Cell Carcinoma

Yang, Li; Gao, Shengtao; Hu, Qi; Wu, Fanglong

doi:10.3390/life12050757

Cited by 6 publications

(5 citation statements)

References 102 publications

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“…As in other cancer types, exosomes are deeply involved in HNSCC progression, and the correlation between exosome release and HNSCC aggressiveness is supported by multiple lines of evidence (108,109). In this context, the release of EGFR-containing exosomes from HNSCCs has been demonstrated to occur both in vitro and in vivo.…”

Section: Involvement Of Non-canonical Erbb Signaling In Hnsccmentioning

confidence: 92%

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Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma

et al. 2023

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type, has often an aggressive course and is poorly responsive to current therapeutic approaches, so that 5-year survival rates for patients diagnosed with advanced disease is lower than 50%. The Epidermal Growth Factor Receptor (EGFR) has emerged as an established oncogene in HNSCC. Indeed, although HNSCCs are a heterogeneous group of cancers which differ for histological, molecular and clinical features, EGFR is overexpressed or mutated in a percentage of cases up to about 90%. Moreover, aberrant expression of the other members of the ErbB receptor family, ErbB2, ErbB3 and ErbB4, has also been reported in variable proportions of HNSCCs. Therefore, an increased expression/activity of one or multiple ErbB receptors is found in the vast majority of patients with HNSCC. While aberrant ErbB signaling has long been known to play a critical role in tumor growth, angiogenesis, invasion, metastatization and resistance to therapy, more recent evidence has revealed its impact on other features of cancer cells’ biology, such as the ability to evade antitumor immunity. In this paper we will review recent findings on how ErbB receptors expression and activity, including that associated with non-canonical signaling mechanisms, impacts on prognosis and therapy of HNSCC.

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Section: Involvement Of Non-canonical Erbb Signaling In Hnsccmentioning

confidence: 92%

“…On the whole, these findings highlight that more research is warranted to fully define the involvement of ErbB receptors-containing exosomes in HNSCC, to validate their possible relevance as non-invasive diagnostic/prognostic markers and to explore their potential as therapeutic targets (13,108,109).…”

Section: Involvement Of Non-canonical Erbb Signaling In Hnsccmentioning

confidence: 98%

Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma

et al. 2023

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“…Exosomes are effectively nano-sized extracellular vesicles for delivery and communication between cells. Several of their biomolecules [20][21][22] are more abundant in cancer cells than in non-cancer cells [22][23][24][25][26][27][28][29][30][31], indicating that exosomes assist in regulating cancer growth [20,32], radioprotection [33,34], radiosensitivity [35,36], drug resistance [37], invasion [38], and metastasis [39]. Exosome biogenesis is proportional to the degree of regulation for exosomal assembly and secretion [40][41][42][43][44][45][46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Connection between Radiation-Regulating Functions of Natural Products and miRNAs Targeting Radiomodulation and Exosome Biogenesis

Tang

Chuang

Shiau

et al. 2023

IJMS

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Exosomes are cell-derived membranous structures primarily involved in the delivery of the payload to the recipient cells, and they play central roles in carcinogenesis and metastasis. Radiotherapy is a common cancer treatment that occasionally generates exosomal miRNA-associated modulation to regulate the therapeutic anticancer function and side effects. Combining radiotherapy and natural products may modulate the radioprotective and radiosensitizing responses of non-cancer and cancer cells, but there is a knowledge gap regarding the connection of this combined treatment with exosomal miRNAs and their downstream targets for radiation and exosome biogenesis. This review focuses on radioprotective natural products in terms of their impacts on exosomal miRNAs to target radiation-modulating and exosome biogenesis (secretion and assembly) genes. Several natural products have individually demonstrated radioprotective and miRNA-modulating effects. However, the impact of natural-product-modulated miRNAs on radiation response and exosome biogenesis remains unclear. In this review, by searching through PubMed/Google Scholar, available reports on potential functions that show radioprotection for non-cancer tissues and radiosensitization for cancer among these natural-product-modulated miRNAs were assessed. Next, by accessing the miRNA database (miRDB), the predicted targets of the radiation- and exosome biogenesis-modulating genes from the Gene Ontology database (MGI) were retrieved bioinformatically based on these miRNAs. Moreover, the target-centric analysis showed that several natural products share the same miRNAs and targets to regulate radiation response and exosome biogenesis. As a result, the miRNA–radiomodulation (radioprotection and radiosensitization)–exosome biogenesis axis in regard to natural-product-mediated radiotherapeutic effects is well organized. This review focuses on natural products and their regulating effects on miRNAs to assess the potential impacts of radiomodulation and exosome biogenesis for both the radiosensitization of cancer cells and the radioprotection of non-cancer cells.

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“…Several exosomal noncoding RNAs (ncRNAs) have been reported, including circular RNAs, long noncoding RNAs (lncRNAs), and microRNAs (miRNAs) [ 1 , 2 , 3 ]. The secretion of exosomes is higher in cancer than in normal cells [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ], suggesting that cancer exosomes play a crucial role in regulating cancer cell progression such as proliferation [ 1 , 2 , 13 ], drug resistance [ 1 , 14 ], migration/invasion [ 15 , 16 ], metastasis [ 17 ], and tumor microenvironments (TME) [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural Products

Chuang

Shiau

Tang

et al. 2023

Cancers

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Cancerous exosomes contain diverse biomolecules that regulate cancer progression. Modulating exosome biogenesis with clinical drugs has become an effective strategy for cancer therapy. Suppressing exosomal processing (assembly and secretion) may block exosomal function to reduce the proliferation of cancer cells. However, the information on natural products that modulate cancer exosomes lacks systemic organization, particularly for exosomal long noncoding RNAs (lncRNAs). There is a gap in the connection between exosomal lncRNAs and exosomal processing. This review introduces the database (LncTarD) to explore the potential of exosomal lncRNAs and their sponging miRNAs. The names of sponging miRNAs were transferred to the database (miRDB) for the target prediction of exosomal processing genes. Moreover, the impacts of lncRNAs, sponging miRNAs, and exosomal processing on the tumor microenvironment (TME) and natural-product-modulating anticancer effects were then retrieved and organized. This review sheds light on the functions of exosomal lncRNAs, sponging miRNAs, and exosomal processing in anticancer processes. It also provides future directions for the application of natural products when regulating cancerous exosomal lncRNAs.

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Functional Properties of Cancer Epithelium and Stroma-Derived Exosomes in Head and Neck Squamous Cell Carcinoma

Cited by 6 publications

References 102 publications

Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma

Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma

Connection between Radiation-Regulating Functions of Natural Products and miRNAs Targeting Radiomodulation and Exosome Biogenesis

Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural Products

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