Functional properties of beetroot (Beta vulgaris) in management of cardio-metabolic diseases

Abstract

Red beetroot (Beta vulgaris), as a naturally occurring root vegetable and a rich source of phytochemicals and bioactive compounds, is known for its beneficial roles in the improvement of several clinical and pathologic outcome. Chronic and acute beetroot juice supplementation, as a cost-effective strategy, is proposed to hold promises in controlling diabetes and insulin hemostasis, blood pressure and vascular function, renal health and the possible effect on microbiome abundance. The secondary outcome and physiological response of microbiome abundance modulation included the non-significant fluctuation of systolic and diastolic blood pressures. Also, some studies have suggested a reno-protective property of beetroot juice that is associated with the reduction of mortality rate and favorable changes in kidney's functional parameters among patients with renal disorders. Similarly, it is shown that the persistent consumption of beetroot juice effectively postpones the postprandial glycemic response and decreases the blood glucose peak. The significant blood pressure lowering effect has been seen among normotensive subjects, which tend to be more considerable among hypertensive individuals and progressive among overweight adults. Within this context, this review aims to provide a comprehensive overview on the therapeutic applications of beetroot juice in metabolic disorders and theirs underlying mechanisms. Despite the inconsistencies in the set of results from the reviewed studies, there is no doubt that further contributing factors must be investigated more deeply in future studies.

The synergistic hepatoprotective potential of Beta vulgaris juice and 2,3- dimercaptosuccinic acid in lead-intoxicated rats via improving the hepatic oxidative and inflammatory stress

“…In addition, it contains many functional constituents such as polyphenols, vitamins, minerals, and others. Therefore, BV is considered as a medicinal plant with hepatoprotective and antioxidant effects and can be used in the treatment of several diseases [11]. In the present study, the functional constituents and antioxidant properties of BVJ were examined to explain its expected hepatoprotective action against Pb intoxication in rats.…”

Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS‐Dependent XBP1/ACC &SCD1 and ERS‐Independent SREBP/FAS Pathways

“…An epidemiological study involving 1938 healthy adults showed that intake of adequate phytochemicals was beneficial, lowering body weight and body fat. [10] Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, especially in broccoli, was reported to regulate a number of metabolic enzymes including phase I & phase II metabolic enzymes, and lipid metabolism-related enzymes/proteins. [11] Oral administration of the sulfur-radish extract and sulforaphane after carbon tetrachloride (CCl 4 )-induced liver injury decreased the serum level of alanine aminotransferase (ALT), reduced the necrotic zones, inhibited lipid peroxidation, and induced phase 2 enzymes without affecting cytochrome P450-2E1 (CYP2E1).…”

“…SFN decreased the lipid accumulation in vivo and in vitro. Three doses of SFN(5,10, and 20 mg kg -1 ) and PPC (30 mg kg -1 ) were orally gavaged to rats three times a week along with HFD diet. And HHL-5 hepatocytes were pretreated with SFN (1, 5, 10, 20 μmol L -1 ) for 24 h, followed by 0.25 mmol L -1 FAs (oleic acid: palmitic acid, 2:1) for 5 days.…”

The benefits and risks of beetroot juice consumption: a systematic review

“…It therefore lacks a large amount of recent studies performed in this rapidly growing field of research. Reviews analyzing the effect of BRJ on broader subject populations were not systematic reviews and again mostly only included a specific outcome, such as the effect on training physiology and performance (Olsson et al 2019), or the properties of BRJ in relation to cardiometabolic disorders (Mirmiran et al 2020). Other reviews again focus on the effect of BRJ on specific populations, such as the effect on women , or the effect on exercise performance in heart failure with reduced ejection fraction (Mulkareddy et al 2019).…”