Functional properties of anti-inflammatory substances from quercetin-treated <i>Bifidobacterium adolescentis</i>

Kawabata, Kyuichi; Baba, Naomichi; Sakano, Taiken; Hamano, Yoshimitsu; Taira, Shu; Tamura, Akira; Baba, Seigo; Natsume, Mitsutaka; Ishii, Takeshi; Murakami, Shigeru; Ohigashi, Hajime

doi:10.1080/09168451.2017.1401916

Cited by 20 publications

(16 citation statements)

References 33 publications

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“…However, F. prausnitzii and R. faecis were confirmed to participate in short-chain fatty acids (SCFAs) biosynthesis. B. adolescentis could secrete small molecule anti-inflammatory substances and inhibit inflammation ( 30 ). Eubacterium rectale could degrade starch in the human intestine and competitively inhibited the growth of harmful bacteria ( 31 ).…”

Section: Resultsmentioning

confidence: 99%

Bacterial Alterations in Post-Cholecystectomy Patients Are Associated With Colorectal Cancer

Ren

Zhang

et al. 2020

Front. Oncol.

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Background: Although increasing evidences showed a correlation between cholecystectomy and the prevalence rate of colorectal cancer (CRC), and shed light on gut microbiota in colorectal pathogenesis, only a few studies focused on microbial alterations after cholecystectomy, and its sequent role in carcinogenesis and progression of CRC has not been reported. Thus, we aimed to investigate the bacterial alterations and tried to clarify their clinical significance. Methods: 104 subjects were enrolled and divided into post-cholecystectomy patients (PC, n = 52) and healthy controls (HC, n = 52). To investigate the bacterial role in carcinogenesis, PC patients were further separated into preCA_CRC (patients with precancerous lesions and/or CRC, n = 9) and non-CA (patients without precancerous lesions and CRC, n = 43) based on the histopathology. Qualified stool samples were collected for 16S rRNA gene sequencing to analyze the bacterial profile. Results: Our data showed noteworthy compositional and abundant alterations of bacterial microbiota in PC patients, characterized as Bacteroides ovatus, Prevotella copri , and Fusobacterium varium remarkably increased; Faecalibacterium prausnitzii, Roseburia faecis , and Bifidobacterium adolescentis significantly decreased. Additionally, the duration after cholecystectomy was the critical factor that affected bacterial composition. Machine learning-based analysis showed a pivotal role of Megamonas funiformis in discriminating PC from HC subjects and involving in the progression of CRC. Conclusions: The bacterial dysbiosis may associate with CRC in PC patients, and the duration after cholecystectomy was highlighted as an important factor. Altered bacterial microbiota was likely to play a pivotal role in related-disease in the long-term follow-up of PC patients.

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Section: Resultsmentioning

confidence: 99%

Bacterial Alterations in Post-Cholecystectomy Patients Are Associated With Colorectal Cancer

Ren

Zhang

et al. 2020

Front. Oncol.

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“…On the other hand, these polyphenols were not able to potentiate the anti-inflammatory activity of lactic acid bacteria. Phenolic acids, which are assumed to be catabolites of these polyphenols, and the bifidobacteria metabolites, acetate and lactate, have no such effect [125,164], suggesting that these polyphenols may make B. adolescentis produce unknown active compounds. Interestingly, stearic acid has been tentatively identified as the anti-inflammatory compound obtained from the culture supernatant of quercetin-treated bifidobacteria [164].…”

Section: Physiological Functions Mediated By Intestinal Microbiotamentioning

confidence: 99%

“…Phenolic acids, which are assumed to be catabolites of these polyphenols, and the bifidobacteria metabolites, acetate and lactate, have no such effect [125,164], suggesting that these polyphenols may make B. adolescentis produce unknown active compounds. Interestingly, stearic acid has been tentatively identified as the anti-inflammatory compound obtained from the culture supernatant of quercetin-treated bifidobacteria [164]. Taken together, these findings suggest that polyphenols reaching the large intestine may not only be catabolized to small phenolic acids, but also elicit potentially beneficial effects of intestinal probiotic bacteria.…”

Section: Physiological Functions Mediated By Intestinal Microbiotamentioning

confidence: 99%

Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols

2019

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Polyphenols are categorized as plant secondary metabolites, and they have attracted much attention in relation to human health and the prevention of chronic diseases. In recent years, a considerable number of studies have been published concerning their physiological function in the digestive tract, such as their prebiotic properties and their modification of intestinal microbiota. It has also been suggested that several hydrolyzed and/or fission products, derived from the catabolism of polyphenols by intestinal bacteria, exert their physiological functions in target sites after transportation into the body. Thus, this review article focuses on the role of intestinal microbiota in the bioavailability and physiological function of dietary polyphenols. Monomeric polyphenols, such as flavonoids and oligomeric polyphenols, such as proanthocyanidins, are usually catabolized to chain fission products by intestinal bacteria in the colon. Gallic acid and ellagic acid derived from the hydrolysis of gallotannin, and ellagitannin are also subjected to intestinal catabolism. These catabolites may play a large role in the physiological functions of dietary polyphenols. They may also affect the microbiome, resulting in health promotion by the activation of short chain fatty acids (SCFA) excretion and intestinal immune function. The intestinal microbiota is a key factor in mediating the physiological functions of dietary polyphenols.

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“… 91 Stearic acid is tentatively identified as the anti-inflammatory molecule from B. adolescentis stimulated by quercetin. 92 …”

Section: Anti-inflammatory Effects Of Quercetin Via Intestinal Microbmentioning

confidence: 99%

<p>Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity</p>

Sato

Mukai

2020

JIR

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Obesity has become a major risk factor for the development of chronic diseases such as insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. Moreover, obesity induces chronic inflammation in adipose tissue, liver, skeletal muscle, and the vascular system. Quercetin is the major representative of the flavonoid subclass of flavonols, which is ubiquitously contained within natural plants such as green tea, and vegetables, including onions and apples. Researchers have focused greater attention to the beneficial physiological roles of quercetin, which has anti-oxidative, anti-inflammatory, and anti-fibrotic effects on insulin resistance and atherosclerosis in obesity-related diseases. Also, the anti-inflammatory effects of quercetin on intestinal microbiota have been demonstrated in obesity. In addition, there is increasing evidence that quercetin is associated with epigenetic activities in cancer, and in maternal undernutrition during gestation and lactation. In this review, we focus on the chemical properties of quercetin, its dietary sources in obesity, and its anti-inflammatory effects on insulin resistance, atherosclerosis, intestinal microbiota, and maternal under-nutrition with epigenetic activity.

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Functional properties of anti-inflammatory substances from quercetin-treated Bifidobacterium adolescentis

Cited by 20 publications

References 33 publications

Bacterial Alterations in Post-Cholecystectomy Patients Are Associated With Colorectal Cancer

Bacterial Alterations in Post-Cholecystectomy Patients Are Associated With Colorectal Cancer

Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols

<p>Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity</p>

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