Functional polysaccharides of fucoidan, laminaran and alginate from Malaysian brown seaweeds (Sargassum polycystum, Turbinaria ornata and Padina boryana)

Fauziee, Nur Afifah Mohd; Chang, Lee Sin; Mustapha, Wan Aida Wan; Nor, Adibi Rahiman Md; Lim, Seng Joe

doi:10.1016/j.ijbiomac.2020.11.067

Cited by 66 publications

(37 citation statements)

References 53 publications

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“…The derivative organic compound of carbohydrate of powder sample was found 28.81 ± 0.08 (g/100g/ DW). In compared to other forages, carbohydrates of brown seaweeds such as Padina gymnospora (26.9% DW) and Sargassum ilicifolium (32.9% DW) [36]. The similar results were observed in Sargassum ilicifolium (27.33% DW) and Sargassum polycystum (25.0) [37].…”

Section: Proximate Composition Of L Variegatasupporting

confidence: 57%

Nutritional Assessment on Brown Macro algae Lobophora variegata from GOMBR, Tamil Nadu, India

Nithya

Archana

Kokila

et al. 2022

JOAASR

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Nutrition is very important to all living organisms and human beings obtained range of nutrition from different resources. Despite this fact, marine natural resources provide unique nutrition to human society. Based on that reason, the present study was conducted to analysis nutritional profile of brown seaweed Lobophora variegata (J.V. Lamouroux) Womersley ex. Oliveira collected from the Gulf of Mannar Biosphere, Tamil Nadu, India. The proximate composition (moisture, ash, protein, lipid, carbohydrate, and dietary fiber, mineral, amino acid , fatty acid and antioxidant activity (2-dipheny- 1 – picrylhydrazyl (DPPH) and Reducing power assays) of L.veriegata. The result indicated that the maximum concentration of protein (34.09 ± 0.95 mg/100g), carbohydrate (28.81 ± 0.07 mg/100g) and total dietary fiber (2.53 ± 0.037 mg/100g) soluble fiber (1.28 ± 0.07 mg/100g) and insoluble fiber (1.50 ± 0.07 mg/100g) recorded in the brown algae L. variegata. The mineral content of L. variegata exhibits high amount of minerals, such as Magnesium (1712.6 ± 16.75 mg/100g DW), Phosphorus (1477.3 ± 4.49 mg/100g DW), Potassium (1078.3 ± 6.23 mg/100g), Sodium (916.6 ± 4.47 mg/100g), Iron (913.6 ± 4.49 mg/100g DW), Zinc (813.6 ± 12.47 mg/100g) and Copper (427.3 ± 5.24 mg/100g DW). Fatty acid profile of docosahexaenoic acid (5.89 ± 0.021mg) and palmitic methyl ester (5.33 ±0.09 mg) were predominantly found in L. variegata. Finally the amino acids are essential (12.43±0.04 mg/g) and non essential (16.99±0.05 mg/g) respectively. DPPH scavenging of Ic50 (175.41µg /ml,) and reducing powder (186.26µg /ml) respectively. According to the current findings, brown seaweed, L. variegata, appears to be a viable marine natural resource for generating innovative nutraceutical and antioxidant products.

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Section: Proximate Composition Of L Variegatasupporting

confidence: 57%

Nutritional Assessment on Brown Macro algae Lobophora variegata from GOMBR, Tamil Nadu, India

Nithya

Archana

Kokila

et al. 2022

JOAASR

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“…Fauziee et al showed that commercial fucoidan also had a wide absorption band near 3400 cm −1 , which corresponded to O–H stretching vibrations of polysaccharides. The band range between 1220 and 1230 cm −1 indicated the existence of S=O stretching [ 50 ]. This is consistent with the spectral results of fucoidan we extracted.…”

Section: Discussionmentioning

confidence: 99%

Nutritional and Chemical Composition of Sargassum zhangii and the Physical and Chemical Characterization, Binding Bile Acid, and Cholesterol-Lowering Activity in HepG2 Cells of Its Fucoidans

Lin

Chen

Zhong

2022

Foods

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Fucoidan is a marine sulfated polysaccharide that is rich in Sargassum and has a wide range of biological activities. In this study, the chemical composition and bile acid binding ability of six crude fucoidans were compared, the nutrition and chemical composition of Sargassum zhangii were analyzed, and fucoidan from Sargassum zhangii was extracted and purified. The purified fractions (ZF1, ZF2, and ZF3) were analyzed by physicochemical characterization, and the ability of binding bile acid and cholesterol lowering in HepG2 cells were evaluated. The results showed that the contents of sulfate in crude fucoidan from Sargassum Zhangii (ZF) was as high as13.63%. Its ability of binding bile acid was better than other five crude fucoidans. Sargassum zhangii was a kind of brown seaweed with high carbohydrate, and low fat and rich in minerals. The sulfate content of ZF1, ZF2, and ZF3 was 3.29%, 19.39%, and 18.89% respectively, and the molecular weight (Mw) was 4.026 × 105, 2.893 × 105, and 3.368 × 105, respectively. Three fucoidans all contained the characteristic absorption bands of polysaccharides and sulfate groups and were rich in fucose. Three fucoidans can bind to bile acid, and ZF2 showed the best binding capability. In vitro experiments showed that ZF1, ZF2, and ZF3 could reduce intracellular total cholesterol (TC) content in HepG2 cells without affecting their viability. ZF2 showed the best ability to reduce TC.

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“…All compounds (stock solution of 2 mg/mL) displayed DPPH • scavenging activity in the range of 60-80% and • OH scavenging activity between 40 and 90%. These compounds were less active against superoxide anion radicals [256].…”

Section: Polysaccharidesmentioning

confidence: 94%

Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Review

et al. 2022

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Currently, there is no known cure for neurodegenerative disease. However, the available therapies aim to manage some of the symptoms of the disease. Human neurodegenerative diseases are a heterogeneous group of illnesses characterized by progressive loss of neuronal cells and nervous system dysfunction related to several mechanisms such as protein aggregation, neuroinflammation, oxidative stress, and neurotransmission dysfunction. Neuroprotective compounds are essential in the prevention and management of neurodegenerative diseases. This review will focus on the neurodegeneration mechanisms and the compounds (proteins, polyunsaturated fatty acids (PUFAs), polysaccharides, carotenoids, phycobiliproteins, phenolic compounds, among others) present in seaweeds that have shown in vivo and in vitro neuroprotective activity. Additionally, it will cover the recent findings on the neuroprotective effects of bioactive compounds from macroalgae, with a focus on their biological potential and possible mechanism of action, including microbiota modulation. Furthermore, gastrointestinal digestion, absorption, and bioavailability will be discussed. Moreover, the clinical trials using seaweed-based drugs or extracts to treat neurodegenerative disorders will be presented, showing the real potential and limitations that a specific metabolite or extract may have as a new therapeutic agent considering the recent approval of a seaweed-based drug to treat Alzheimer’s disease.

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Functional polysaccharides of fucoidan, laminaran and alginate from Malaysian brown seaweeds (Sargassum polycystum, Turbinaria ornata and Padina boryana)

Cited by 66 publications

References 53 publications

Nutritional Assessment on Brown Macro algae Lobophora variegata from GOMBR, Tamil Nadu, India

Nutritional Assessment on Brown Macro algae Lobophora variegata from GOMBR, Tamil Nadu, India

Nutritional and Chemical Composition of Sargassum zhangii and the Physical and Chemical Characterization, Binding Bile Acid, and Cholesterol-Lowering Activity in HepG2 Cells of Its Fucoidans

Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Review

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