2011
DOI: 10.1530/jme-11-0067
|View full text |Cite
|
Sign up to set email alerts
|

Functional polymorphisms within the TNFRSF11B (osteoprotegerin) gene increase the risk for low bone mineral density

Abstract: Polymorphisms within the TNFRSF11B gene have been studied and associated with osteoporosis and fracture risk. Osteoprotegerin (OPG), the product of this gene, is a key negative regulator of osteoclastogenesis and is secreted by osteoblasts/stromal cells. A previous study in Maltese postmenopausal women showed positive association of low bone mineral density (BMD) with a polymorphism found within the promoter region of this gene (C950T). In this study, direct DNA sequencing revealed 12 variants with polymorphis… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

4
25
0
7

Year Published

2013
2013
2021
2021

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 41 publications
(36 citation statements)
references
References 25 publications
(30 reference statements)
4
25
0
7
Order By: Relevance
“…The OPG gene is one of the most important candidate genes for BMD and osteoporosis (Pocock et al, 1987;Hofbauer and Schoppet, 2002;Langdahl et al, 2002;Yamada et al, 2003;Arko et al, 2002Arko et al, , 2005Vidal et al, 2011;Feng et al, 2012;Hussien et al, 2013;Zhang et al, 2013). Osteoporosis is a polygenic disease that results from complex interactions between genetic and environmental factors.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…The OPG gene is one of the most important candidate genes for BMD and osteoporosis (Pocock et al, 1987;Hofbauer and Schoppet, 2002;Langdahl et al, 2002;Yamada et al, 2003;Arko et al, 2002Arko et al, , 2005Vidal et al, 2011;Feng et al, 2012;Hussien et al, 2013;Zhang et al, 2013). Osteoporosis is a polygenic disease that results from complex interactions between genetic and environmental factors.…”
Section: Discussionmentioning
confidence: 99%
“…Genetic factors play important roles in the pathogenesis of osteoporosis (Albagha and Ralston, 2006;Ferrari, 2008;Cheung et al, 2010;Hosoi, 2010;Ralston, 2010;Feng et al, 2012;Woo et al, 2012;Zhang et al, 2013). Previous studies have indicated several genes associated with BMD and osteoporosis, such as the osteoprotegerin (OPG) gene (Pocock et al, 1987;Hofbauer and Schoppet, 2002;Langdahl et al, 2002;Yamada et al, 2003;Arko et al, 2002Arko et al, , 2005Vidal et al, 2011;Feng et al, 2012;Hussien et al, 2013;Zhang et al, 2013), the estrogen receptor alpha gene (Kurt et al, 2012), and the vitamin D receptor (VDR) gene (Fang et al, 2005;Jakubowska-Pietkiewicz et al, 2012;Kurt et al, 2012;Li et al, 2012;Hussien et al, 2013;Horst-Sikorska et al, 2013). OPG has been considered one of the most important candidate genes for BMD and osteoporosis among these genes.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…BMD is known to be highly heritable, and an increasing number of genes have been identified to have independent effects on BMD in osteoporosis, including pre-B-cell leukemia homeobox 1 (PBX1) (Cheung et al, 2009), apolipoprotein E (APOE) (Singh et al, 2010), Jagged1 (JAG1) (Kung et al, 2010), TWIST1 gene (Hwang et al, 2010), TN-FRSF11B (osteoprotegerin) (Vidal et al, 2011), and SOX6 (Yang et al, 2012). In addition, in osteoporotic women, femoral neck BMD shows associations with vitamin D receptor gene (VDR), and lumbar spine BMD with osteoprotegerin (OPG) and tumor necrosis factor superfamily member 11 (TNFSF11) (Mencej-Bedrač et al, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…Low BMD is a major risk factor for primary osteoporosis (Nguyen et al, 2000;Lee et al, 2010;Ozbas et al, 2012). To date, several studies have reported that some functional genes, for example, the osteoprotegerin (OPG) gene (Pocock et al, 1987;Hofbauer and Schoppet, 2002;Langdahl et al, 2002;Yamada et al, 2003;Arko et al, 2002Arko et al, , 2005Vidal et al, 2011;Feng et al, 2012;Hussien et al, 2013;Zhang et al, 2013), the vitamin D receptor (VDR) gene (Fang et al, 2005;Jakubowska-Pietkiewicz et al, 2012;Kurt et al, 2012;Li et al, 2012;Hussien et al, 2013;Horst-Sikorska et al, 2013), and the estrogen receptor alpha (ERalpha) gene (Kurt et al, 2012), affected BMD and primary osteoporosis. Among these candidate genes, OPG is one of the most important.…”
Section: Introductionmentioning
confidence: 99%