Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinoma

Methylenetetrahydrofolate Reductase Gene Polymorphisms as Predictive and Prognostic Biomarkers in Ovarian Cancer Risk

“…The role of MTHFR C677T polymorphism on the survival of patients has also been reported in different types of malignancies with inconsistent results Upadhyay et al, 2008;Upadhyay et al, 2009). Also, population specific differences was found in cancer susceptibility as well as allele frequency of gene polymorphism by several studies (Miller et al, 1988;Shen et al, 2001;Wilcken et al, 2003;Reddy and Jamil., 2006;Sarbia et al, 2006;Jain et al, 2008;Upadhyay et al, 2008;Joshi et al, 2009;Upadhyay et al, 2009). However, there is no study explore the association between MTHFR C677T polymorphism and survival of ovarian cancer in Chinese population.…”

Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis

“…SNPs in NCF4 (rs729749), NCF2 (rs789181) and RAC2 (rs1476002) genes were found to be mildly associated with RA only in men. 28 Moreover, the association of COX-2 polymorphisms with disease risk and response to NSAID varies between sexes, 29,30 most likely as a result of sexual dimorphism in PGE 2 metabolism. Systemic biosynthesis of PGE 2 differs markedly between males and females in human, as in mice.…”

Association of ADAM33 gene polymorphisms with asthma in Indian children

“…Homozygous genotype for the normal allele of each SNP in the control group was used as reference in calculating OR and 95% confidence intervals. 16 …”

“…Fisher's exact test was carried out to avoid type 1 error in the subgroup analyses due to the smaller sample size. 16 Statistical analyses for the haplotype estimation and linkage disequilibrium (LD) were carried out using the expectation-maximization algorithm (Arlequin software version 2.00). 15 The SNPAnalyzer (version 1.0; ISTECH; Istech, Kyungkido, Republic of Korea) was used to calculate D' value, the measure index of LD.…”

“…15 The SNPAnalyzer (version 1.0; ISTECH; Istech, Kyungkido, Republic of Korea) was used to calculate D' value, the measure index of LD. 16 …”