Functional polymorphisms in the gene encoding macrophage migration inhibitory factor (MIF) are associated with active pulmonary tuberculosis

Abstract

These data suggested a distinct genetic and immunopathogenic basis for tuberculosis at the MIF locus. Serum MIF, IFN-γ and TNF-α profiles distinguish tuberculosis from the more inflammatory phenotype and may play a role in pathogenesis and as biomarkers of active tuberculosis.

Current immunogenetic predisposition to tuberculosis in the Moroccan population

“…The data reported that the MIF −173*C allele was significantly more common in pulmonary TB cases than it was in healthy controls ( p = .02, OR = 1.53, 95% CI 1.05–2.24). The same results were shown for different degrees of TB risk in Chinese population (Kuai et al., ; Li et al., ; Liu et al., ; Wang, Zhang, Shi, Zhang, & Liu, ) and, more recently, in Iranian populations ( p = .028) (Hashemi et al., ), in which the −173*C allele was found to be associated with susceptibility to TB. This mutation occurred in an interesting region of the MIF promoter.…”

“…Another genetic variant, a −794 (rs5844572) CATT 5–8 microsatellite not yet investigated in Moroccan population, was identified to be associated with TB in Chinese population (Kuai et al., ; Li et al., ; Tong et al., ; Wang et al., ).…”

“…lite not yet investigated in Moroccan population, was identified to be associated with TB in Chinese population (Kuai et al, 2016;Tong et al, 2017;Wang et al, 2016).…”

Macrophage migration inhibitory factor promoter polymorphisms (−794CATT5–7) as potential biomarker for early‐stage cervical cancer

“…Polymorphisms of MIF in the promoter region were identified by SNP MIF‐173(G/C) and MIF‐794 CATT. It was reported in inflammatory diseases that carriers of MIF‐173 C and MIF‐794 CATT 7 or 8 alleles were susceptible to active tuberculosis with MIF in serum significantly increasing . The mechanism might be that MIF polymorphisms are associated with susceptibility to active tuberculosis, and MIF levels in serum may contribute to disease persistence by inducing interferon‐γ and tumor necrosis factor‐α to promote inflammatory responses by means of positive feedback loop .…”

“…It was reported in inflammatory diseases that carriers of MIF‐173 C and MIF‐794 CATT 7 or 8 alleles were susceptible to active tuberculosis with MIF in serum significantly increasing . The mechanism might be that MIF polymorphisms are associated with susceptibility to active tuberculosis, and MIF levels in serum may contribute to disease persistence by inducing interferon‐γ and tumor necrosis factor‐α to promote inflammatory responses by means of positive feedback loop . It is also reported that polymorphisms of MIF‐173(G/C) and MIF‐794 CATT play important roles in prostatic cancer and gastric cancer .…”