Functional Polyion Complex Micelles for Potential Targeted Hydrophobic Drug Delivery

Kalinova, Radostina; Dimitrov, Ivaylo

doi:10.3390/molecules27072178

Cited by 11 publications

(8 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The driving force of the self-assembly of these amphiphilic copolymers in aqueous media, at the nanometric scale, is the thermodynamic incompatibility between the different sequences (hydrophilic/hydrophobic) [ 3 ]. During the last two decades, PMs have attracted a great interest, in particular owing to their strong ability to solubilize water-insoluble active principles and thus to be effective drug nanocarriers [ 4 , 5 , 6 , 7 ]. Like surfactant micelles, polymer micelles have a core–corona structure capable of encapsulation various types of molecules.…”

Section: Introductionmentioning

confidence: 99%

Drug Delivery Systems Based on Pluronic Micelles with Antimicrobial Activity

et al. 2022

View full text Add to dashboard Cite

Bacterial oral diseases are chronic, and, therefore, require appropriate treatment, which involves various forms of administration and dosing of the drug. However, multimicrobial resistance is an increasing issue, which affects the global health system. In the present study, a commercial amphiphilic copolymer, Pluronic F127, was used for the encapsulation of 1-(5′-nitrobenzimidazole-2′-yl-sulphonyl-acetyl)-4-aryl-thiosemicarbazide, which is an original active pharmaceutical ingredient (API) previously synthesized and characterized by our group, at different copolymer/API weight ratios. The obtained micellar systems, with sizes around 20 nm, were stable during 30 days of storage at 4 °C, without a major increase of the Z-average sizes. As expected, the drug encapsulation and loading efficiencies varied with the copolymer/API ratio, the highest values of 84.8 and 11.1%, respectively being determined for the F127/API = 10/1 ratio. Moreover, in vitro biological tests have demonstrated that the obtained polymeric micelles (PMs) are both hemocompatible and cytocompatible. Furthermore, enhanced inhibition zones of 36 and 20 mm were observed for the sample F127/API = 2/1 against S. aureus and E. coli, respectively. Based on these encouraging results, it can be admitted that these micellar systems can be an efficient alternative for the treatment of bacterial oral diseases, being suitable either by injection or by a topical administration.

show abstract

Section: Introductionmentioning

confidence: 99%

Drug Delivery Systems Based on Pluronic Micelles with Antimicrobial Activity

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Three varieties of polymers are frequently employed in micelle fabrication: diblock copolymers, which consist of polystyrene and PEG [ 112 ]; triblock copolymers, which encompass polyethylene oxide (PEO) [ 113 ]; and graft copolymers, which include stearic acid and chitosan [ 114 ]. Multiple advantages in using polymeric micelles for drug delivery could be considered, such as their target specificity, tissue penetration ability, high drug-loading capacity, high stability, biodegradability, biocompatibility, low toxicity, and controlled-release features [ 115 , 116 ].…”

Section: Icariin-loaded Nanoplatformsmentioning

confidence: 99%

Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms

Mohammadzadeh,

Zarei,

Abbasi

et al. 2024

J Biol Eng

View full text Add to dashboard Cite

There is an increasing demand for innovative strategies that effectively promote osteogenesis and enhance bone regeneration. The critical process of bone regeneration involves the transformation of mesenchymal stromal cells into osteoblasts and the subsequent mineralization of the extracellular matrix, making up the complex mechanism of osteogenesis. Icariin’s diverse pharmacological properties, such as anti-inflammatory, anti-oxidant, and osteogenic effects, have attracted considerable attention in biomedical research. Icariin, known for its ability to stimulate bone formation, has been found to encourage the transformation of mesenchymal stromal cells into osteoblasts and improve the subsequent process of mineralization. Several studies have demonstrated the osteogenic effects of icariin, which can be attributed to its hormone-like function. It has been found to induce the expression of BMP-2 and BMP-4 mRNAs in osteoblasts and significantly upregulate Osx at low doses. Additionally, icariin promotes bone formation by stimulating the expression of pre-osteoblastic genes like Osx, RUNX2, and collagen type I. However, icariin needs to be effectively delivered to bone to perform such promising functions.Encapsulating icariin within nanoplatforms holds significant promise for promoting osteogenesis and bone regeneration through a range of intricate biological effects. When encapsulated in nanofibers or nanoparticles, icariin exerts its effects directly at the cellular level. Recalling that inflammation is a critical factor influencing bone regeneration, icariin's anti-inflammatory effects can be harnessed and amplified when encapsulated in nanoplatforms. Also, while cell adhesion and cell migration are pivotal stages of tissue regeneration, icariin-loaded nanoplatforms contribute to these processes by providing a supportive matrix for cellular attachment and movement. This review comprehensively discusses icariin-loaded nanoplatforms used for bone regeneration and osteogenesis, further presenting where the field needs to go before icariin can be used clinically.

show abstract

“…The presence of proteolytic enzymes and the acidic environment of the stomach make the drug susceptible to degradation before reaching the intestine . Moreover, low drug bioavailability into the bloodstream is limited, especially for hydrophobic drugs, such as dexamethasone, curcumin, , amphotericin B, and insulin. − The low bioavailability occurs due to poor permeability through the intestinal mucosal layer …”

Section: Chitosan-based Biomaterials For Drug Delivery Systemmentioning

confidence: 99%

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

Budiarso,

Rini,

Tsalsabila

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Over the past decade, smart and functional biomaterials have escalated as one of the most rapidly emerging fields in the life sciences because the performance of biomaterials could be improved by careful consideration of their interaction and response with the living systems. Thus, chitosan could play a crucial role in this frontier field because it possesses many beneficial properties, especially in the biomedical field such as excellent biodegradability, hemostatic properties, antibacterial activity, antioxidant properties, biocompatibility, and low toxicity. Furthermore, chitosan is a smart and versatile biopolymer due to its polycationic nature with reactive functional groups that allow the polymer to form many interesting structures or to be modified in various ways to suit the targeted applications. In this review, we provide an up-to-date development of the versatile structures of chitosan-based smart biomaterials such as nanoparticles, hydrogels, nanofibers, and films, as well as their application in the biomedical field. This review also highlights several strategies to enhance biomaterial performance for fast growing fields in biomedical applications such as drug delivery systems, bone scaffolds, wound healing, and dentistry.

show abstract

Functional Polyion Complex Micelles for Potential Targeted Hydrophobic Drug Delivery

Cited by 11 publications

References 44 publications

Drug Delivery Systems Based on Pluronic Micelles with Antimicrobial Activity

Drug Delivery Systems Based on Pluronic Micelles with Antimicrobial Activity

Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

Contact Info

Product

Resources

About