Functional plasticity of human respiratory tract dendritic cells: GM-CSF enhances TH2 development

Faith, A.; McDonald, John G.; Peek, Emma; Richards, David F.; Caulfield, Jason; Chevretton, Elfy B; Roberts, David; Lee, Tak H.; Corrigan, Christopher; Hawrylowicz, Catherine M.

doi:10.1016/j.jaci.2005.08.002

Cited by 33 publications

(39 citation statements)

References 33 publications

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“…IL-3 is one of the most important members of interleukin family in early haematopoietic cell function; it is involved in survival, proliferation, differentiation and maturation of HSCs 26 . GM-CSF drives differentiation towards the granulocyte and macrophage lineages and G-CSF has a specific role in the production of neutrophils 27 . Thrombopoietin (TPO), a ligand for the c-mpl cytokine receptor, is the primary regulator of megakaryocyte differentiation and functions as a modulator of platelet production and release 28 .…”

Section: The Extrinsic Regulators Of Hscmentioning

confidence: 99%

“…For example ephrin-A5 induces signaling within the ephrin-A expressing cell when bound to its cognate Eph receptor [27][28][29].…”

Section: Eph/ephrin Activation and Signalingmentioning

confidence: 99%

“…Through these mechanisms Eph function effects not only the processes of embryogenesis but also specialized cellular function in adult tissues, including bone remodeling, immune function and synaptic plasticity as well as cell proliferation and survival specific tissue stem cells as described further below [27,30].…”

Section: Expression and Function Of The Eph And Ephrin Genesmentioning

confidence: 99%

“…Cell repulsion occurs when bidirectional signaling triggers cytoskeletal contraction, loss of focal adhesions, cell rounding and cell detachment, whereas cell attachment occurs when signals are in favor of cell adhesion and migration [31]. This interaction influence many different cell behaviors during embryogenesis and in adult life [27]. Eph/ephrin interactions mediate formation of tissue boundaries (e.g.…”

Section: Expression and Function Of The Eph And Ephrin Genesmentioning

confidence: 99%

“…hindbrain rhombomeres) [32], control axon guidance during development and also tissue morphogenesis and patterning [33,34]. Eph/ephrin interactions are also involved in development of vascular system [35], stem cell biology [36], hematopoiesis, erythropoiesis, immune function and in tumor invasion and metastasis [27,30,[37][38][39].…”

Section: Expression and Function Of The Eph And Ephrin Genesmentioning

confidence: 99%

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The role of Eph proteins in haematopoiesis and leukaemia

Charmsaz¹

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When HSCs from wild type mice were transduced with the MLL-AF9 retrovirus and engrafted into recipient mice, the subsequent leukaemias showed significant expression of EphA2 on leukemic blast cells. However when EphA2 null HSCs were engrafted, the absence of EphA2 appeared to have no effect on the leukemic process, demonstrating that EphA2 is not essential for leukaemia progression. Analysis showing increased expression of EphA7 and other Eph proteins demonstrate a possible compensatory role for the lack EphA2 expression, if Eph signalling was required for leukemic evolution in this model. Following these observations, the role iii of EphA2 as a therapeutic target for MLL-AF9 leukaemia was evaluated. Results showed that radiolabelled (beta particle-emitting lutetium) EphA2 was an effective therapeutic approach by significantly delaying the progression of MLL-AF9 leukaemia. Given the poor prognosis of MLL-driven paediatric acute lymphoblastic leukaemia (ALL) this data raises the prospect of effective EphA2-targeted therapy for this disease.EphA3 is another member of the Eph/ephrin family of RTKs, which was originally described in leukaemia and has subsequently been described in many other different cancers including sarcomas, lung cancer, melanoma and glioblastoma. The EphA3-specific monoclonal antibody, IIIA4, binds and activates both human and mouse

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Section: The Extrinsic Regulators Of Hscmentioning

confidence: 99%

“…For example ephrin-A5 induces signaling within the ephrin-A expressing cell when bound to its cognate Eph receptor [27][28][29].…”

Section: Eph/ephrin Activation and Signalingmentioning

confidence: 99%

Section: Expression and Function Of The Eph And Ephrin Genesmentioning

confidence: 99%

Section: Expression and Function Of The Eph And Ephrin Genesmentioning

confidence: 99%

Section: Expression and Function Of The Eph And Ephrin Genesmentioning

confidence: 99%

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The role of Eph proteins in haematopoiesis and leukaemia

Charmsaz¹

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Mapping mononuclear phagocytes in blood, lungs, and lymph nodes of sarcoidosis patients

Lepzien

Rankin

Pourazar

et al. 2019

Journal of Leukocyte Biology

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Sarcoidosis is a T‐cell driven inflammatory disease characterized by granuloma formation. Mononuclear phagocytes (MNPs)—macrophages, monocytes, and dendritic cells (DCs)—are likely critical in sarcoidosis as they initiate and maintain T cell activation and contribute to granuloma formation by cytokine production. Granulomas manifest primarily in lungs and lung‐draining lymph nodes (LLNs) but these compartments are less studied compared to blood and bronchoalveolar lavage (BAL). Sarcoidosis can present with an acute onset (usually Löfgren's syndrome (LS)) or a gradual onset (non‐LS). LS patients typically recover within 2 years while 60% of non‐LS patients maintain granulomas for up to 5 years. Here, four LS and seven non‐LS patients underwent bronchoscopy with endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA). From each patient, blood, BAL, endobronchial biopsies (EBBs), and LLN samples obtained by EBUS‐TBNA were collected and MNPs characterized using multicolor flow cytometry. Six MNP subsets were identified at varying frequencies in the anatomical compartments investigated. Importantly, monocytes and DCs were most mature with migratory potential in BAL and EBBs but not in the LLNs suggesting heterogeneity in MNPs in the compartments typically affected in sarcoidosis. Additionally, in LS patients, frequencies of DC subsets were lower or lacking in LLNs and EBBs, respectively, compared to non‐LS patients that may be related to the disease outcome. Our work provides a foundation for future investigations of MNPs in sarcoidosis to identify immune profiles of patients at risk of developing severe disease with the aim to provide early treatment to slow down disease progression.

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Dendritic Cells in Rhinitis

KleinJan

Lambrecht

Dendritic Cells

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Dendritic cells (DCs) play an important role in all kind of rhinitis and sinusitis. One of the most important upper airway diseases is allergic rhinitis. DCs are the professional antigen presenting cells that have the capacity to present antigen to naive-T cells and T-effector cells. In the context of a broad spectrum of rhinitis, from allergic rhinitis via upper respiratory tract virus infection to chronic sinusitis, DCs have an important role in the immunological outcome of the disease. Studies in humans and animal models that have highlighted the role of DC were evaluated. This article reviews recent information on the involvement of DC in rhinitis, and the mechanisms by which DC could be employed as targets for therapeutic intervention.

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Functional plasticity of human respiratory tract dendritic cells: GM-CSF enhances TH2 development

Cited by 33 publications

References 33 publications

The role of Eph proteins in haematopoiesis and leukaemia

The role of Eph proteins in haematopoiesis and leukaemia

Mapping mononuclear phagocytes in blood, lungs, and lymph nodes of sarcoidosis patients

Dendritic Cells in Rhinitis

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