Functional plasticity of glutamatergic neurons of medullary reticular nuclei after spinal cord injury in mice
Maxime Lemieux,
Narges Karimi,
Frederic Bretzner
Abstract:Spinal cord injury disrupts the descending command from the brain and causes a range of motor deficits. Here, we use optogenetic tools to investigate the functional plasticity of the glutamatergic reticulospinal drive of the medullary reticular formation after a lateral thoracic hemisection in female mice. Sites evoking stronger excitatory descending drive in intact conditions are the most impaired after injury, whereas those associated with a weaker drive are potentiated. After lesion, pro- and anti-locomotor… Show more
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