Functional Pathology of Certain Cardiovascular Malformations Which May Be Treated Surgically

Edwards, Jesse E.

doi:10.1001/archsurg.1950.01250021113012

Cited by 5 publications

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“…This leads us to appreciate that among a group of patients with the same anatomic diagnosis regarding the cardiac malformation, the physiologic and clinical behavior may be so diverse, depending on pulmonary vascular response, that superficially some patients could hardly seem to be harboring the same malformation as others. [17][18][19][20][21][22] One of our early experiences with the interrelationship of the pulmonary vessels and cardiac malformations concerned a 7-year-old girl who was observed in 1947. Dr. Howard B. Burchell, who had studied the patient clinically, thought that she had coarctation of the aorta proximal to a patent ductus arteriosus, and that the right ventricle was supplying blood to the descending aorta.…”

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The Lewis A. Conner Memorial Lecture

Edwards

1957

Circulation

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137

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While there are many anatomic varieties of congenital malformations of the heart and great vessels, most may be divided, from a functional point of view, into 3 types: (1) Conner also had keen insight into the specific problems of the individual patient. He was a pioneer more than 40 years ago in emphasizing facts which then were controversial and which we accept today as commonplace. His interests in the pulmonary complications of the patient with typhoid fever led to a clear appreciation of the relationship of peripheral venous thrombosis to pulmonary embolism.He indicated that peripheral venous thrombosis might be clinically latent and yet be responsible for pulmonary embolism.' 2 The pulmonary embolism might be recurrent and not necessarily fatal. In stressing these facts, he brought out the concept that in a patient with a disease seemingly unrelated to the lungs, there might be pulmonary manifestations that were, in fact, somehow related to the basic nonpulmonary disease.

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confidence: 99%