Functional ovarian cysts in premenopausal and gynecologically healthy women

Christensen, J.T.; Boldsen, Jesper L.; Westergaard, J.G.

doi:10.1016/s0010-7824(02)00353-0

Cited by 67 publications

(40 citation statements)

References 20 publications

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“…Christensen et al reported that among the overall population of 428 gynecologically healthy women, 29 (7%, ages 16-43) were found to have ovarian cysts. 40 In this study, there were significant changes of endometrial thickness and ovarian cyst formation in women undergoing adjuvant hormonal therapy after breast cancer surgery. When compared with anastrozole, tamoxifen led to much thicker endometrium after 3 years of medication.…”

Section: -15mentioning

confidence: 63%

The effect of adjuvant hormonal therapy on the endometrium and ovary of breast cancer patients

2008

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Objective:To investigate the effect of adjuvant hormonal therapy on the endometrium and ovary of breast cancer patients. Methods: A retrospective review was performed on the 207 patients who had taken tamoxifen or anastrozole, as adjuvant hormonal therapy after breast cancer surgery between January 2003 and December 2006. Gynecologic surveillance constituted of ultrasonographic exam of the endometrial thickness and ovarian cyst formation. The patients were classified into three groups and analyzed; premenopausal/postmenopausal women receiving tamoxifen and women receiving anastrozole. Results: Mean duration of follow up?was 20.6±6.6 months. There was no difference of mean endometrial thickness before hormonal therapy among the three groups (p=0.327). In women receiving tamoxifen, the endometrium was continuously thickened in proportion to the duration of the therapy irrespective of menopausal status while it remained unchanged in women receiving anastrozole (p＜0.05). Endometrial biopsies were performed in 28 patients receiving tamoxifen. The most common histologic finding was proliferative endometrium in premenopausal women (7/21) and atrophic endometrium in postmenopausal women (6/7). There was no case of endometrial cancer in both groups. Ovarian cyst was found in 32 women and the most were developed in premenopausal women receiving tamoxifen (30/32). All of them showed benign nature on transvaginal ultrasonographic findings. Conclusion: Women undergoing adjuvant hormonal therapy after breast cancer surgery exhibited changes in the endometrium and ovary. However most changes were not a serious problem in this study and frequent gynecologic surveillance in these patients needs further investigation.

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Section: -15mentioning

confidence: 63%

The effect of adjuvant hormonal therapy on the endometrium and ovary of breast cancer patients

2008

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“…The frequency of mutations in BRAF and KRAS in cystadenomas associated with SBTs was significantly higher than those without SBTs (P Ͻ 0.001, Fisher's exact test; Table 2). This finding together with the fact that SBTs are relatively uncommon as compared to cystadenomas (21)(22)(23)(24)(25) suggests that only a small proportion of serous cystadenomas are neoplastic with the potential to progress to SBTs. Finally, our findings suggest a "gatekeeper" role of BRAF and KRAS genes in the development of low-grade serous carcinomas (26).…”

Section: Discussionmentioning

confidence: 99%

Mutations of BRAF and KRAS Precede the Development of Ovarian Serous Borderline Tumors

Ho¹,

Kurman

Dehari³

et al. 2004

Cancer Research

191

125

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Molecular genetic changes that are associated with the initiating stage of tumor development are important in tumorigenesis. Ovarian serous borderline tumors (SBTs), putative precursors of low-grade serous carcinomas, are among the few human neoplasms with a high frequency of activating mutations in BRAF and KRAS genes. However, it remains unclear as to how these mutations contribute to tumor progression. To address this issue, we compared the mutational status of BRAF and KRAS in both SBTs and the adjacent epithelium from cystadenomas, the presumed precursor of SBTs. We found that three of eight SBTs contained mutant BRAF, and four SBTs contained mutant KRAS. All specimens with mutant BRAF harbored wild-type KRAS and vice versa. Thus, seven (88%) of eight SBTs contained either BRAF or KRAS mutations. The same mutations detected in SBTs were also identified in the cystadenoma epithelium adjacent to the SBTs in six (86%) of seven informative cases. As compared to SBTs, the cystadenoma epithelium, like ovarian surface epithelium, lacks cytological atypia. Our findings provide cogent evidence that mutations of BRAF and KRAS occur in the epithelium of cystadenomas adjacent to SBTs and strongly suggest that they are very early events in tumorigenesis, preceding the development of SBT.

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“…Jørgensgård (Ehlers, 1898;Andersen, 1969;Møller-Christensen, 1978). The "negative" marks of selecting those classified as suffering from leprosy out of the population were observed in an urban cemetery from the Middle Ages (Christensen and Boldsen, 2001). Only recently was it more generally accepted that people suffering from leprosy were also buried in ordinary cemeteries belonging to parish and monastic churches (Arcini, 1999;Boldsen, 2001).…”

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confidence: 99%

Leprosy and mortality in the Medieval Danish village of Tirup

Boldsen¹

2004

American J Phys Anthropol

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Leprosy was a well-recognized and dreaded disease in Denmark in the Middle Ages (AD 1000-1536). A large fraction of the population was affected by leprosy in the 13th century. This paper analyzes the correlation between signs of leprosy and risk of dying in the small Danish village of Tirup (AD 1150-1350). Seven different dichotomous osteological lesions indicative of leprosy are analyzed, and it is possible to score at least one of these conditions on 135 skeletons of adult or adolescent people (aged 14 or more). Scores were transformed to a statistic, lambda, indicating the likelihood that the person to whom the skeleton belonged suffered from leprosy. The analyses indicate that the prevalence of leprosy among adult people in Tirup was 26% (95% confidence interval, 17-35%). The lambda statistic indicates that people who died with signs of leprosy did not differ in the distribution of age at death from those who did not have such signs. Skeletons showing dental enamel hypoplasia were less likely to come from skeletons with high lambda-values. The association between lambda and dental enamel hypoplasia indicates a relationship between stress in early childhood (ages 1-6 years) and subsequent development of signs of leprosy.

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Functional ovarian cysts in premenopausal and gynecologically healthy women

Cited by 67 publications

References 20 publications

The effect of adjuvant hormonal therapy on the endometrium and ovary of breast cancer patients

The effect of adjuvant hormonal therapy on the endometrium and ovary of breast cancer patients

Mutations of BRAF and KRAS Precede the Development of Ovarian Serous Borderline Tumors

Leprosy and mortality in the Medieval Danish village of Tirup

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