Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer

Ohigashi, Seiji; Hoshino, Yoshinori; Ohde, Sachiko; Onodera, Hisashi

doi:10.1007/s00595-010-4450-6

Cited by 90 publications

(83 citation statements)

References 25 publications

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“…Most patients seem to adjust well to their illness [11], although patients with more advanced stages of cancer [24,25], rectal cancer [24][25][26] and a stoma [27][28][29] have been found to experience lower health-related quality of life. It might be that these subgroups of colorectal cancer patients experience more illness-related hindrance in goal attainment and thus report poorer well-being.…”

Section: Introductionmentioning

confidence: 97%

Changes in cancer patients’ personal goals in the first 6 months after diagnosis: the role of illness variables

Janse

Ranchor

Smink

et al. 2014

Support Care Cancer

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Section: Introductionmentioning

confidence: 97%

Changes in cancer patients’ personal goals in the first 6 months after diagnosis: the role of illness variables

Janse

Ranchor

Smink

et al. 2014

Support Care Cancer

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“…Therefore, the current survey study contributes to the efforts to fill that particular gap in knowledge. Moreover, given the increasing evidence that probiotics have a significant role to play in improving QoL in a variety of conditions, such as, for instance, colorectal cancer [26], cystic fibrosis [27], or a variety of gastrointestinal, immune and metabolic conditions [28,29], the authors wanted to continue building up the evidence base with regard to the effect of Renadyl™ on persons with CKD. That renal failure patients have pathogenic gut microbes is now evident from a large number of researches.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life in Chronic Kidney Disease Patients Using a Synbiotic Dietary Supplement: a Survey

2017

International Journal of Research Studies in Medical and Health

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Background: A synbiotic dietary supplement Renadyl™, which is being used by over 3000 CKD customers, was studied in a customer survey. The focus was health status and Quality of Life (QoL). Methods: Survey questionnaires were sent to 951 current repeat customers of Kibow Biotech Inc. Of those, 117 were excluded due to mailing errors and other reasons. The final sample size was 834. Results were tabulated and analysed using Statistical Analysis Software (SAS) V9.2 and Microsoft MS Excel. Results: A total of 168 responses were received (20% response rate, 42% female, 47% male, ages 12-98 years). A majority (85%) were over 51 years of age, in stage III or IV of kidney disease (58%) with at least one comorbid condition (77%), and almost half (48%) were retired. A majority (61%) reported experiencing at least some or even great improvement since they started taking Renadyl™. Statistical analysis indicated a significant difference (p<0.0001) in distributions in quality of life when comparing responses before and after taking Renadyl. Multivariate analysis indicated that the duration of Renadyl™ administration (p<0.0001), employment (p<0.012), comorbidity (p<0.012), and Glomerular Filtration Rate (GFR) (p<0.0015) were significant factors influencing the reported quality of life. Even the disabled respondents all reported significant improvement. Conclusions: Renadyl™ appears to provide at least some benefit in all stages of CKD and with a variety of comorbid conditions. It does not interfere with any other medical treatments, including dialysis. It appears to have a stabilizing effect on the overall health status and quality of life, maintaining or improving kidney health in particular. These findings reinforce the results of our 2013 survey and highlight the possible potential of modulating the gut microbiome with specifically chosen combination of probiotic strains and prebiotics. Further adequately powered studies that could establish a clearer correlation between Renadyl™ and its impact on GFR are warranted.

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“…Patients in the right group exhibited the most marked improvement, with defecation frequency, feeling of incomplete evacuation and global HRQoL on the SF-36 significantly ameliorated. In the left group, the frequency of defecation, role of emotion on the SF-36 and constipation in the EORTC QLQ-C30 were improved; in the rectal group, global HRQoL, constipation and diarrhea in the EORTC QLQ-C30 were improved [79]. The authors speculated that the postoperative changes in the intestinal flora appear to be improved by administration of probiotics, which contributed to improvement of stool frequency, particularly in patients undergoing right colectomy, who had been unavoidingly subjected to the loss of their ileocecal valve [79].…”

Section: Clinical Studiesmentioning

confidence: 96%

“…The authors speculated that the postoperative changes in the intestinal flora appear to be improved by administration of probiotics, which contributed to improvement of stool frequency, particularly in patients undergoing right colectomy, who had been unavoidingly subjected to the loss of their ileocecal valve [79]. While there are adverse effects of sympa-thetic and parasympathetic nerve resection, which are distributed widely throughout the rectum, sigmoid and left colon, probiotics may potentially affect the resulting postoperative intestinal motility disorder [79][80][81]. The lack of a placebo group was the main drawback of the latter study.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…In a prospective clinical study, Ohigashi et al [79] examined the functional outcome and the HRQoL after surgery for cancer at different locations (right, left colon and rectum). The Guard (Kowa, Nagoya, Japan), a product containing Bacillus natto and L. acidophilus as principal probiotics, was provided to 77 patients in doses of three tablets, three times a day (total daily dose 10 mg of B. natto and 30 mg of L. acidophilus) for a period of 3 months.…”

Section: Clinical Studiesmentioning

confidence: 99%

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Probiotics, Prebiotics, Synbiotics: Is There Enough Evidence to Support Their Use in Colorectal Cancer Surgery?

Peitsidou

Karantanos²,

Theodoropoulos³

2012

Dig Surg

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Background/Aims: Pro-/pre-/synbiotics supplementation seems to provide beneficial effects in various aspects of abdominal pathology. Skepticism exists with respect to their effects on colorectal cancer (CRC) patients. This review presents the potential clinical applications of pro-/pre-/synbiotics in CRC surgery. Methods: A literature search of electronic databases was conducted and all studies published on ‘probiotics’, ‘prebiotics’ and ‘synbiotics’ were collected. Among them, the ones referring to CRC and which had any clinical relevance offering information on perioperative parameters were used. Results: Incorporation of pre-/pro-/synbiotic formulations in the preoperative mechanical bowel preparation cannot be supported by the current evidence. Limited clinical studies may be promising in supporting their potentially protective role against postoperative infectious complications. Encouraging are the results on their protective role against adjuvant (chemo)radiation-induced diarrhea. Such supplementation may also hold promise to improve postcolectomy gastrointestinal related quality of life. Conclusions: Despite the positive results and plethora of agents, bacterial combinations and concentrations, the inconsistency in administration, the inhomogeneity of comparison groups and lack of stringent clinical endpoints remain obstacles in the effort to establish a definitive clinical strategy at this time. Further work is warranted to gain a keen understanding of their clinical value in CRC patients.

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Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer

Abstract: Not only rectal resection but also rightside colectomy affected bowel dysfunction. Probiotics could be an effective treatment for improvement in functional outcome and QOL after colorectal resection.

Cited by 90 publications

References 25 publications

Changes in cancer patients’ personal goals in the first 6 months after diagnosis: the role of illness variables

Changes in cancer patients’ personal goals in the first 6 months after diagnosis: the role of illness variables

Quality of Life in Chronic Kidney Disease Patients Using a Synbiotic Dietary Supplement: a Survey

Probiotics, Prebiotics, Synbiotics: Is There Enough Evidence to Support Their Use in Colorectal Cancer Surgery?

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